4pq7 - Revision history

OCA at 17:20, 20 September 2023

OCA — Wed, 20 Sep 2023 17:20:30 GMT

←Older revision		Revision as of 17:20, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [https://pdbe.org/4pq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [https://pdbe.org/4pq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:24, 8 February 2023

OCA — Wed, 08 Feb 2023 07:24:17 GMT

←Older revision		Revision as of 07:24, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pq7' size='340' side='right'caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4pq7' size='340' side='right'caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [https://pdbe.org/4pq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [~~http~~://pdbe.org/4pq7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alterio, V]]	+	[[Category: Alterio V]]
-	[[Category: Simone, G ~~De]]~~	+	[[Category: De Simone G]]
-	~~[[Category: Lyase-lyase inhibitor complex]]~~	+
-	~~[[Category: Sulfamide]]~~	+
-	~~[[Category: Zinc binding~~]]	+

OCA at 08:10, 17 April 2019

OCA — Wed, 17 Apr 2019 08:10:48 GMT

←Older revision		Revision as of 08:10, 17 April 2019
Line 1:		Line 1:

	==The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor==		==The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor==
-	<StructureSection load='4pq7' size='340' side='right' caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4pq7' size='340' side='right'caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [http://pdbe.org/4pq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [http://pdbe.org/4pq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>
Line 29:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Alterio, V]]		[[Category: Alterio, V]]
	[[Category: Simone, G De]]		[[Category: Simone, G De]]

OCA at 16:39, 11 August 2016

OCA — Thu, 11 Aug 2016 16:39:11 GMT

←Older revision		Revision as of 16:39, 11 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor==		==The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor==
	<StructureSection load='4pq7' size='340' side='right' caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4pq7' size='340' side='right' caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pq7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [http://pdbe.org/4pq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pq7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 20 January 2015

OCA — Tue, 20 Jan 2015 10:50:47 GMT

←Older revision		Revision as of 10:50, 20 January 2015
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: Alterio, V.]]	+	[[Category: Alterio, V]]
-	[[Category: Simone, G De.]]	+	[[Category: Simone, G De]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
	[[Category: Sulfamide]]		[[Category: Sulfamide]]
	[[Category: Zinc binding]]		[[Category: Zinc binding]]

OCA at 07:37, 8 October 2014

OCA — Wed, 08 Oct 2014 07:37:17 GMT

←Older revision		Revision as of 07:37, 8 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor==
		+	<StructureSection load='4pq7' size='340' side='right' caption='[[4pq7]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pq7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQ7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IL3:1-BUT-2-YNOXY-4-[(SULFAMOYLAMINO)METHYL]BENZENE'>IL3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pq7 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A new series of compounds containing a sulfamide moiety as zinc-binding group (ZBG) has been synthesized and tested for determining inhibitory properties against four human carbonic anhydrase (hCA) isoforms, namely, CAs I, II, IX, and XII. The X-ray structure of the cytosolic dominant isoform hCA II in complex with the best inhibitor of the series has also been determined providing further insights into sulfamide binding mechanism and confirming that such zinc-binding group, if opportunely derivatized, can be usefully exploited for obtaining new potent and selective CAIs. The analysis of the structure also suggests that for drug design purposes the but-2-yn-1-yloxy moiety tail emerges as a very interesting substituent of the phenylmethylsulfamide moiety due to its capability to establish strong van der Waals interactions with a hydrophobic cleft on the hCA II surface, delimited by residues Phe131, Val135, Pro202, and Leu204. Indeed, the complementarity of this tail with the cleft suggests that different substituents could be used to discriminate between isoforms having clefts with different sizes.

-	~~The entry 4pq7 is ON HOLD until Paper Publication~~	+	Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors.,De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V Biomed Res Int. 2014;2014:523210. doi: 10.1155/2014/523210. Epub 2014 Sep 2. PMID:25258712<ref>PMID:25258712</ref>

-	~~Authors~~: Alterio, V.~~, De~~ Simone, G.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide~~ inhibitor	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Alterio, V.]]
		+	[[Category: Simone, G De.]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Sulfamide]]
		+	[[Category: Zinc binding]]

OCA at 07:37, 19 March 2014

OCA — Wed, 19 Mar 2014 07:37:37 GMT

←Older revision		Revision as of 07:37, 19 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pq7 is ON HOLD	+	The entry 4pq7 is ON HOLD until Paper Publication

	Authors: Alterio, V., De Simone, G.		Authors: Alterio, V., De Simone, G.

	Description: The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor		Description: The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor

OCA: Protected "4pq7" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 12:35:03 GMT

Protected "4pq7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4pq7 is ON HOLD Authors: Alterio, V., De Simone, G. Description: The crystal structure of the human carbonic anhydrase ii in complex with a sulfami...

OCA — Wed, 12 Mar 2014 12:35:01 GMT

New page: '''Unreleased structure''' The entry 4pq7 is ON HOLD Authors: Alterio, V., De Simone, G. Description: The crystal structure of the human carbonic anhydrase ii in complex with a sulfami...

New page

'''Unreleased structure'''

The entry 4pq7 is ON HOLD

Authors: Alterio, V., De Simone, G.

Description: The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor