4pqo - Revision history

OCA at 12:42, 1 March 2024

OCA — Fri, 01 Mar 2024 12:42:38 GMT

←Older revision		Revision as of 12:42, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [https://pdbe.org/4pqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [https://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [https://pdbe.org/4pqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [https://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SNX14_HUMAN SNX14_HUMAN] May be involved in several stages of intracellular trafficking (By similarity).		[https://www.uniprot.org/uniprot/SNX14_HUMAN SNX14_HUMAN] May be involved in several stages of intracellular trafficking (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Sorting nexins (SNXs) or phox homology (PX) domain containing proteins are central regulators of cell trafficking and signaling. A sub-family of PX domain proteins possesses two unique PX-associated domains, as well as a regulator of GPCR signaling (RGS) domain that attenuates Galphas-coupled GPCR-signaling. Here we delineate the structural organization of these RGS-PX proteins, revealing a protein family with a modular architecture that is conserved in all eukaryotes. The one exception to this is mammalian SNX19, which lacks the typical RGS structure but preserves all other domains. The PX domain is a sensor of membrane phosphoinositide lipids and we find that specific sequence alterations in the PX domains of the mammalian RGS-PX proteins, SNX13, SNX14, SNX19 and SNX25, confer differential phosphoinositide binding preferences. While SNX13 and SNX19 PX domains bind the early endosomal lipid phosphatidylinositol 3-phosphate (PtdIns3P), SNX14 shows no membrane binding at all. Crystal structures of the SNX19 and SNX14 PX domains reveal key differences, with alterations in SNX14 leading to closure of the binding pocket to prevent phosphoinositide association. Our findings suggest a role for alternative membrane interactions in spatial control of RGS-PX proteins in cell signaling and trafficking.
-
-	Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.,Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R, Ona Yanez LE, Davis JL, Teasdale RD, Collins BM J Biol Chem. 2014 Aug 22. pii: jbc.M114.595959. PMID:25148684<ref>PMID:25148684</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4pqo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]		*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:24, 8 February 2023

OCA — Wed, 08 Feb 2023 07:24:55 GMT

←Older revision		Revision as of 07:24, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pqo' size='340' side='right'caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4pqo' size='340' side='right'caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [https://pdbe.org/4pqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [https://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [~~http~~://pdbe.org/4pqo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SNX14_HUMAN SNX14_HUMAN]] May be involved in several stages of intracellular trafficking (By similarity).	+	[https://www.uniprot.org/uniprot/SNX14_HUMAN SNX14_HUMAN] May be involved in several stages of intracellular trafficking (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
-	*[[Sorting nexin\|Sorting nexin]]	+	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bugarcic, A]]	+	[[Category: Bugarcic A]]
-	[[Category: Collins, B]]	+	[[Category: Collins B]]
-	[[Category: Kinna, G]]	+	[[Category: Kinna G]]
-	[[Category: Kovtun, O]]	+	[[Category: Kovtun O]]
-	[[Category: Leneva, N]]	+	[[Category: Leneva N]]
-	[[Category: Mas, C]]	+	[[Category: Mas C]]
-	[[Category: Norwood, S]]	+	[[Category: Norwood S]]
-	[[Category: Teasdale, R]]	+	[[Category: Teasdale R]]
-	~~[[Category: Phosphoinositide binding]]~~	+
-	~~[[Category: Phox homology domain]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sorting nexin~~]]	+

OCA at 08:14, 17 April 2019

OCA — Wed, 17 Apr 2019 08:14:35 GMT

←Older revision		Revision as of 08:14, 17 April 2019
Line 1:		Line 1:

	==Structure of the human SNX14 PX domain in space group I41==		==Structure of the human SNX14 PX domain in space group I41==
-	<StructureSection load='4pqo' size='340' side='right' caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='4pqo' size='340' side='right'caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNX14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://pdbe.org/4pqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://pdbe.org/4pqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bugarcic, A]]		[[Category: Bugarcic, A]]
	[[Category: Collins, B]]		[[Category: Collins, B]]

OCA at 14:07, 5 August 2016

OCA — Fri, 05 Aug 2016 14:07:04 GMT

←Older revision		Revision as of 14:07, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the human SNX14 PX domain in space group I41==		==Structure of the human SNX14 PX domain in space group I41==
	<StructureSection load='4pqo' size='340' side='right' caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4pqo' size='340' side='right' caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://pdbe.org/4pqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pqo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pqo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sorting nexin\|Sorting nexin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:25, 25 December 2014

OCA — Thu, 25 Dec 2014 19:25:39 GMT

←Older revision		Revision as of 19:25, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNX14_HUMAN SNX14_HUMAN]] May be involved in several stages of intracellular trafficking (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bugarcic, A.]]	+	[[Category: Bugarcic, A]]
-	[[Category: Collins, B.]]	+	[[Category: Collins, B]]
-	[[Category: Kinna, G.]]	+	[[Category: Kinna, G]]
-	[[Category: Kovtun, O.]]	+	[[Category: Kovtun, O]]
-	[[Category: Leneva, N.]]	+	[[Category: Leneva, N]]
-	[[Category: Mas, C.]]	+	[[Category: Mas, C]]
-	[[Category: Norwood, S.]]	+	[[Category: Norwood, S]]
-	[[Category: Teasdale, R.]]	+	[[Category: Teasdale, R]]
	[[Category: Phosphoinositide binding]]		[[Category: Phosphoinositide binding]]
	[[Category: Phox homology domain]]		[[Category: Phox homology domain]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Sorting nexin]]		[[Category: Sorting nexin]]

OCA at 09:18, 29 October 2014

OCA — Wed, 29 Oct 2014 09:18:07 GMT

←Older revision		Revision as of 09:18, 29 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:51, 4 September 2014

OCA — Thu, 04 Sep 2014 05:51:47 GMT

←Older revision		Revision as of 05:51, 4 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the human SNX14 PX domain in space group I41==
		+	<StructureSection load='4pqo' size='340' side='right' caption='[[4pqo]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pqp\|4pqp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqo RCSB], [http://www.ebi.ac.uk/pdbsum/4pqo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sorting nexins (SNXs) or phox homology (PX) domain containing proteins are central regulators of cell trafficking and signaling. A sub-family of PX domain proteins possesses two unique PX-associated domains, as well as a regulator of GPCR signaling (RGS) domain that attenuates Galphas-coupled GPCR-signaling. Here we delineate the structural organization of these RGS-PX proteins, revealing a protein family with a modular architecture that is conserved in all eukaryotes. The one exception to this is mammalian SNX19, which lacks the typical RGS structure but preserves all other domains. The PX domain is a sensor of membrane phosphoinositide lipids and we find that specific sequence alterations in the PX domains of the mammalian RGS-PX proteins, SNX13, SNX14, SNX19 and SNX25, confer differential phosphoinositide binding preferences. While SNX13 and SNX19 PX domains bind the early endosomal lipid phosphatidylinositol 3-phosphate (PtdIns3P), SNX14 shows no membrane binding at all. Crystal structures of the SNX19 and SNX14 PX domains reveal key differences, with alterations in SNX14 leading to closure of the binding pocket to prevent phosphoinositide association. Our findings suggest a role for alternative membrane interactions in spatial control of RGS-PX proteins in cell signaling and trafficking.

-	~~The entry 4pqo is ON HOLD until Paper Publication~~	+	Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.,Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R, Ona Yanez LE, Davis JL, Teasdale RD, Collins BM J Biol Chem. 2014 Aug 22. pii: jbc.M114.595959. PMID:25148684<ref>PMID:25148684</ref>

-	~~Authors: Mas~~, C.~~, Norwood,~~ S., Bugarcic, A., Kinna, G., Leneva, N., ~~Kovtun, O~~., Teasdale, R.~~, Collins, B.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of the human SNX14 PX~~ domain ~~in space group I41~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bugarcic, A.]]
		+	[[Category: Collins, B.]]
		+	[[Category: Kinna, G.]]
		+	[[Category: Kovtun, O.]]
		+	[[Category: Leneva, N.]]
		+	[[Category: Mas, C.]]
		+	[[Category: Norwood, S.]]
		+	[[Category: Teasdale, R.]]
		+	[[Category: Phosphoinositide binding]]
		+	[[Category: Phox homology domain]]
		+	[[Category: Protein transport]]
		+	[[Category: Sorting nexin]]

OCA at 06:33, 30 April 2014

OCA — Wed, 30 Apr 2014 06:33:40 GMT

←Older revision		Revision as of 06:33, 30 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pqo is ON HOLD	+	The entry 4pqo is ON HOLD until Paper Publication

	Authors: Mas, C., Norwood, S., Bugarcic, A., Kinna, G., Leneva, N., Kovtun, O., Teasdale, R., Collins, B.		Authors: Mas, C., Norwood, S., Bugarcic, A., Kinna, G., Leneva, N., Kovtun, O., Teasdale, R., Collins, B.

	Description: Structure of the human SNX14 PX domain in space group I41		Description: Structure of the human SNX14 PX domain in space group I41

OCA: Protected "4pqo" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 12:35:46 GMT

Protected "4pqo" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4pqo is ON HOLD Authors: Mas, C., Norwood, S., Bugarcic, A., Kinna, G., Leneva, N., Kovtun, O., Teasdale, R., Collins, B. Description: Structure of...

OCA — Wed, 12 Mar 2014 12:35:44 GMT

New page: '''Unreleased structure''' The entry 4pqo is ON HOLD Authors: Mas, C., Norwood, S., Bugarcic, A., Kinna, G., Leneva, N., Kovtun, O., Teasdale, R., Collins, B. Description: Structure of...

New page

'''Unreleased structure'''

The entry 4pqo is ON HOLD

Authors: Mas, C., Norwood, S., Bugarcic, A., Kinna, G., Leneva, N., Kovtun, O., Teasdale, R., Collins, B.

Description: Structure of the human SNX14 PX domain in space group I41