4pvg - Revision history

OCA at 17:23, 20 September 2023

OCA — Wed, 20 Sep 2023 17:23:03 GMT

←Older revision		Revision as of 17:23, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [https://pdbe.org/4pvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [https://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [https://pdbe.org/4pvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [https://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:32, 8 February 2023

OCA — Wed, 08 Feb 2023 07:32:54 GMT

←Older revision		Revision as of 07:32, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pvg' size='340' side='right'caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4pvg' size='340' side='right'caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [https://pdbe.org/4pvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [https://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [~~http~~://pdbe.org/4pvg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[~~http~~://omim.org/entry/151100 151100]]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[~~http~~://omim.org/entry/163950 163950]]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[~~http~~://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[~~http~~://omim.org/entry/156250 156250]]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>	+	[https://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[https://omim.org/entry/151100 151100]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[https://omim.org/entry/163950 163950]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[https://omim.org/entry/156250 156250]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>	+	[https://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Liu D]]
-	[[Category: Liu, D]]	+	[[Category: Yu Z]]
-	[[Category: Yu, Z]]	+	[[Category: Zeng L]]
-	[[Category: Zeng, L]]	+	[[Category: Zhang Z-Y]]
-	[[Category: Zhang, Z Y]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:28, 17 April 2019

OCA — Wed, 17 Apr 2019 07:28:12 GMT

←Older revision		Revision as of 07:28, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79==		==Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79==
-	<StructureSection load='4pvg' size='340' side='right' caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4pvg' size='340' side='right'caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [http://pdbe.org/4pvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [http://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [http://pdbe.org/4pvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [http://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Liu, D]]		[[Category: Liu, D]]

OCA at 17:23, 18 January 2017

OCA — Wed, 18 Jan 2017 17:23:50 GMT

←Older revision		Revision as of 17:23, 18 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79==		==Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79==
	<StructureSection load='4pvg' size='340' side='right' caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4pvg' size='340' side='right' caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [http://www.ebi.ac.uk/pdbsum/4pvg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [http://pdbe.org/4pvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [http://www.ebi.ac.uk/pdbsum/4pvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>		[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:58, 15 April 2015

OCA — Wed, 15 Apr 2015 12:58:23 GMT

←Older revision		Revision as of 12:58, 15 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79==
-		+	<StructureSection load='4pvg' size='340' side='right' caption='[[4pvg]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 4pvg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pvg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVG FirstGlance]. <br>
-	~~Authors~~: ~~Zhang~~, Z.-Y., ~~Zeng~~, L., ~~Liu~~, D., Yu, Z.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WT:2-[3-({4-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-4-OXOBUTANOYL}AMINO)PHENYL]-6-HYDROXY-3-IODO-1-METHYL-1H-INDOLE-5-CARBOXYLIC+ACID'>2WT</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	~~Description~~: ~~Crystal structure~~ of protein tyrosine ~~phosphatase Shp2 catalytic domain complex with small molecular compound L88N79~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvg RCSB], [http://www.ebi.ac.uk/pdbsum/4pvg PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[http://omim.org/entry/151100 151100]]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[http://omim.org/entry/163950 163950]]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[http://omim.org/entry/156250 156250]]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Liu, D]]		[[Category: Liu, D]]
	[[Category: Yu, Z]]		[[Category: Yu, Z]]
-	[[Category: Zhang, Z.-Y]]
	[[Category: Zeng, L]]		[[Category: Zeng, L]]
		+	[[Category: Zhang, Z Y]]
		+	[[Category: Hydrolase]]

OCA at 13:06, 21 January 2015

OCA — Wed, 21 Jan 2015 13:06:49 GMT

←Older revision		Revision as of 13:06, 21 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pvg is ON HOLD	+	The entry 4pvg is ON HOLD until Paper Publication

	Authors: Zhang, Z.-Y., Zeng, L., Liu, D., Yu, Z.		Authors: Zhang, Z.-Y., Zeng, L., Liu, D., Yu, Z.

OCA at 15:15, 24 December 2014

OCA — Wed, 24 Dec 2014 15:15:31 GMT

←Older revision		Revision as of 15:15, 24 December 2014
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	Description: Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79		Description: Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79
		+	[[Category: Unreleased Structures]]
		+	[[Category: Liu, D]]
		+	[[Category: Yu, Z]]
		+	[[Category: Zhang, Z.-Y]]
		+	[[Category: Zeng, L]]

OCA at 08:33, 2 April 2014

OCA — Wed, 02 Apr 2014 08:33:50 GMT

←Older revision		Revision as of 08:33, 2 April 2014
Line 3:		Line 3:
	The entry 4pvg is ON HOLD		The entry 4pvg is ON HOLD

-	Authors: Zhang, ~~Zhong~~-~~Yin~~, Zeng, ~~Lifan~~, Liu, ~~David~~, Yu, ~~Zhihong~~	+	Authors: Zhang, Z.-Y., Zeng, L., Liu, D., Yu, Z.

	Description: Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79		Description: Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79

OCA: Protected "4pvg" [edit=sysop:move=sysop]

OCA — Wed, 26 Mar 2014 08:52:46 GMT

Protected "4pvg" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:52, 26 March 2014

OCA: New page: '''Unreleased structure''' The entry 4pvg is ON HOLD Authors: Zhang, Zhong-Yin, Zeng, Lifan, Liu, David, Yu, Zhihong Description: Crystal structure of protein tyrosine phosphatase Shp2...

OCA — Wed, 26 Mar 2014 08:52:45 GMT

New page: '''Unreleased structure''' The entry 4pvg is ON HOLD Authors: Zhang, Zhong-Yin, Zeng, Lifan, Liu, David, Yu, Zhihong Description: Crystal structure of protein tyrosine phosphatase Shp2...

New page

'''Unreleased structure'''

The entry 4pvg is ON HOLD

Authors: Zhang, Zhong-Yin, Zeng, Lifan, Liu, David, Yu, Zhihong

Description: Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79