4pz1 - Revision history

OCA at 17:24, 20 September 2023

OCA — Wed, 20 Sep 2023 17:24:44 GMT

←Older revision		Revision as of 17:24, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [https://pdbe.org/4pz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [https://pdbe.org/4pz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:37, 8 February 2023

OCA — Wed, 08 Feb 2023 07:37:50 GMT

←Older revision		Revision as of 07:37, 8 February 2023
Line 1:		Line 1:

	==Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes==		==Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes==
-	<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='4pz1' size='340' side='right'caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strp1 Strp1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [https://pdbe.org/4pz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M5005_Spy1730, SPy_2034 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [~~http~~://pdbe.org/4pz1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q99XU0_STRP1 Q99XU0_STRP1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Strp1~~]]	+	[[Category: Large Structures]]
-	[[Category: Bjorck, L]]	+	[[Category: Streptococcus pyogenes serotype M1]]
-	[[Category: Frick, I M]]	+	[[Category: Bjorck L]]
-	[[Category: Happonen, L]]	+	[[Category: Frick I-M]]
-	[[Category: Malmstrom, J]]	+	[[Category: Happonen L]]
-	[[Category: Streicher, W]]	+	[[Category: Malmstrom J]]
-	[[Category: Wikstrom, M]]	+	[[Category: Streicher W]]
-	[[Category: Wisniewska, M]]	+	[[Category: Wikstrom M]]
-	~~[[Category: Helix-loop-helix]]~~	+	[[Category: Wisniewska M]]
-	~~[[Category: Unknown function~~]]	+

OCA at 05:54, 8 March 2018

OCA — Thu, 08 Mar 2018 05:54:16 GMT

←Older revision		Revision as of 05:54, 8 March 2018
Line 3:		Line 3:
	<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp1 Strp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M5005_Spy1730, SPy_2034 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [http://pdbe.org/4pz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [http://pdbe.org/4pz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Strp1]]
	[[Category: Bjorck, L]]		[[Category: Bjorck, L]]
	[[Category: Frick, I M]]		[[Category: Frick, I M]]

OCA at 17:16, 4 January 2017

OCA — Wed, 04 Jan 2017 17:16:26 GMT

←Older revision		Revision as of 17:16, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes==		==Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes==
	<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [http://pdbe.org/4pz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pz1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:51, 11 March 2015

OCA — Wed, 11 Mar 2015 11:51:18 GMT

←Older revision		Revision as of 11:51, 11 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes==
		+	<StructureSection load='4pz1' size='340' side='right' caption='[[4pz1]], [[Resolution\|resolution]] 1.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pz1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mer\|4mer]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pyogenes is a significant bacterial pathogen in the human population. The importance of virulence factors for the survival and colonization of S. pyogenes is well established, and many of these factors are exposed to the extracellular environment enabling bacterial interactions with the host. In the present study we quantitatively analyzed and compared S. pyogenes proteins in the growth medium of a strain that is virulent to mice, with a non-virulent strain. Particularly one of these proteins was present at significantly higher levels in stationary growth medium from the virulent strain. We determined the three-dimensional structure of the protein that showed a unique tetrameric organization composed of four helix-loop-helix motifs. Affinity pull-down mass spectrometry analysis in human plasma demonstrated that the protein interacts with histidine-rich glycoprotein (HRG), and the name sHIP (streptococcal Histidine-rich glycoprotein Interacting Protein) is therefore proposed. HRG has antibacterial activity, and when challenged by HRG, sHIP was found to rescue S. pyogenes bacteria. This and the finding that patients with invasive S. pyogenes infection respond with antibody production against sHIP, suggest a role for the protein in S. pyogenes pathogenesis.

-	~~The entry 4pz1 is ON HOLD until Paper Publication~~	+	Functional and Structural Properties of a Novel Protein and Virulence Factor (sHIP) in Streptococcus pyogenes.,Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmstrom L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Bjorck L, Streicher W, Malmstrom J, Wikstrom M J Biol Chem. 2014 May 13. pii: jbc.M114.565978. PMID:24825900<ref>PMID:24825900</ref>

-	~~Authors: Wisniewska~~, M.~~, Happonen, L~~.~~, Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	~~[[Category: Wikstrom, M]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Bjorck, L]]		[[Category: Bjorck, L]]
-	~~[[Category: Wisniewska, M]]~~	+	[[Category: Frick, I M]]
-	[[Category: Frick, I.-M]]	+
	[[Category: Happonen, L]]		[[Category: Happonen, L]]
		+	[[Category: Malmstrom, J]]
	[[Category: Streicher, W]]		[[Category: Streicher, W]]
-	[[Category: ~~Malmstrom~~, J]]	+	[[Category: Wikstrom, M]]
		+	[[Category: Wisniewska, M]]
		+	[[Category: Helix-loop-helix]]
		+	[[Category: Unknown function]]

OCA at 15:20, 24 December 2014

OCA — Wed, 24 Dec 2014 15:20:07 GMT

←Older revision		Revision as of 15:20, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes		Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes
		+	[[Category: Unreleased Structures]]
		+	[[Category: Wikstrom, M]]
		+	[[Category: Bjorck, L]]
		+	[[Category: Wisniewska, M]]
		+	[[Category: Frick, I.-M]]
		+	[[Category: Happonen, L]]
		+	[[Category: Streicher, W]]
		+	[[Category: Malmstrom, J]]

OCA at 09:08, 16 April 2014

OCA — Wed, 16 Apr 2014 09:08:34 GMT

←Older revision		Revision as of 09:08, 16 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pz1 is ON HOLD	+	The entry 4pz1 is ON HOLD until Paper Publication

	Authors: Wisniewska, M., Happonen, L., Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M.		Authors: Wisniewska, M., Happonen, L., Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M.

	Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes		Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes

OCA: Protected "4pz1" [edit=sysop:move=sysop]

OCA — Wed, 09 Apr 2014 05:58:32 GMT

Protected "4pz1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 9 April 2014

OCA: New page: '''Unreleased structure''' The entry 4pz1 is ON HOLD Authors: Wisniewska, M., Happonen, L., Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M. Description: Crystal st...

OCA — Wed, 09 Apr 2014 05:58:31 GMT

New page: '''Unreleased structure''' The entry 4pz1 is ON HOLD Authors: Wisniewska, M., Happonen, L., Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M. Description: Crystal st...

New page

'''Unreleased structure'''

The entry 4pz1 is ON HOLD

Authors: Wisniewska, M., Happonen, L., Frick, I.-M., Bjorck, L., Streicher, W., Malmstrom, J., Wikstrom, M.

Description: Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes