4q0o - Revision history

OCA at 17:26, 20 September 2023

OCA — Wed, 20 Sep 2023 17:26:03 GMT

←Older revision		Revision as of 17:26, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [https://pdbe.org/4q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [https://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [https://pdbe.org/4q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [https://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:39, 8 February 2023

OCA — Wed, 08 Feb 2023 07:39:38 GMT

←Older revision		Revision as of 07:39, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4q0o' size='340' side='right'caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4q0o' size='340' side='right'caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [https://pdbe.org/4q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [https://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAF180, PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [~~http~~://pdbe.org/4q0o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[~~http~~://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>	+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>	+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Structural genomic]]~~	+
-	~~[[Category: Baf180]]~~	+
-	~~[[Category: Brg1-associated factor 180]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Pb1]]~~	+
-	~~[[Category: Pbrm1]]~~	+
-	~~[[Category: Polybromo 1 isoform 1]]~~	+
-	~~[[Category: Polybromo-1d]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 08:04, 17 April 2019

OCA — Wed, 17 Apr 2019 08:04:42 GMT

←Older revision		Revision as of 08:04, 17 April 2019
Line 1:		Line 1:

	==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==		==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
-	<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='4q0o' size='340' side='right'caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAF180, PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://pdbe.org/4q0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://pdbe.org/4q0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
	</table>		</table>
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 11:18, 11 August 2016

OCA — Thu, 11 Aug 2016 11:18:58 GMT

←Older revision		Revision as of 11:18, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==		==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
	<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://pdbe.org/4q0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 09:02, 5 January 2015

OCA — Mon, 05 Jan 2015 09:02:04 GMT

←Older revision		Revision as of 09:02, 5 January 2015
Line 2:		Line 2:
	<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. <br>	+	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>		[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Baf180]]		[[Category: Baf180]]
	[[Category: Brg1-associated factor 180]]		[[Category: Brg1-associated factor 180]]
Line 35:		Line 34:
	[[Category: Polybromo-1d]]		[[Category: Polybromo-1d]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 08:24, 7 May 2014

OCA — Wed, 07 May 2014 08:24:48 GMT

←Older revision		Revision as of 08:24, 7 May 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
-		+	<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~The entry~~ 4q0o is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. <br>
-	~~Authors~~: ~~Filippakopoulos~~, P., ~~Picaud~~, S., ~~von Delft, F~~., Arrowsmith, C.H., Edwards, A.M., ~~Bountra, C~~., Knapp, S., Structural Genomics Consortium ~~(SGC)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q0n\|4q0n]]</td></tr>
-	~~Description~~: ~~Crystal Structure of the fifth bromodomain of Human Poly~~-~~bromodomain containing protein~~ 1 ~~(PB1) in complex with a hydroxyphenyl~~-~~propenone ligand~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Baf180]]
		+	[[Category: Brg1-associated factor 180]]
		+	[[Category: Bromodomain]]
		+	[[Category: Chromatin regulator]]
		+	[[Category: Dna-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Pb1]]
		+	[[Category: Pbrm1]]
		+	[[Category: Polybromo 1 isoform 1]]
		+	[[Category: Polybromo-1d]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]

OCA: Protected "4q0o" [edit=sysop:move=sysop]

OCA — Wed, 09 Apr 2014 06:00:22 GMT

Protected "4q0o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 9 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q0o is ON HOLD Authors: Filippakopoulos, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomic...

OCA — Wed, 09 Apr 2014 06:00:21 GMT

New page: '''Unreleased structure''' The entry 4q0o is ON HOLD Authors: Filippakopoulos, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomic...

New page

'''Unreleased structure'''

The entry 4q0o is ON HOLD

Authors: Filippakopoulos, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand