4q3s - Revision history

OCA at 17:27, 20 September 2023

OCA — Wed, 20 Sep 2023 17:27:24 GMT

←Older revision		Revision as of 17:27, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [https://pdbe.org/4q3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [https://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [https://pdbe.org/4q3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [https://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 8 February 2023

OCA — Wed, 08 Feb 2023 07:42:47 GMT

←Older revision		Revision as of 07:42, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4q3s' size='340' side='right'caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4q3s' size='340' side='right'caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Blood_fluke Blood fluke~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [https://pdbe.org/4q3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [https://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Smp_059980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [~~http~~://pdbe.org/4q3s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6WVP6_SCHMA Q6WVP6_SCHMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arginase]]
-	[[Category: Blood fluke]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Christianson, D W~~]]	+	[[Category: Schistosoma mansoni]]
-	[[Category: ~~Edwards, J E~~]]	+	[[Category: Christianson DW]]
-	[[Category: ~~Hai, Y~~]]	+	[[Category: Edwards JE]]
-	[[Category: ~~Hoffmann, K F~~]]	+	[[Category: Hai Y]]
-	[[Category: ~~Zandt, M C.Van~~]]	+	[[Category: Hoffmann KF]]
-	[[Category: ~~Arginase-deacetylase fold]]~~	+	[[Category: Van Zandt MC]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 08:47, 24 April 2019

OCA — Wed, 24 Apr 2019 08:47:53 GMT

←Older revision		Revision as of 08:47, 24 April 2019
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	==Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE==		==Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE==
-	<StructureSection load='4q3s' size='340' side='right' caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='4q3s' size='340' side='right'caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Smp_059980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://pdbe.org/4q3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://pdbe.org/4q3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Arginase\|Arginase]]	+	*[[Arginase 3D structures\|Arginase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
		+	[[Category: Blood fluke]]
		+	[[Category: Large Structures]]
	[[Category: Christianson, D W]]		[[Category: Christianson, D W]]
	[[Category: Edwards, J E]]		[[Category: Edwards, J E]]

OCA at 08:15, 11 August 2016

OCA — Thu, 11 Aug 2016 08:15:28 GMT

←Older revision		Revision as of 08:15, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE==		==Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE==
	<StructureSection load='4q3s' size='340' side='right' caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4q3s' size='340' side='right' caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://pdbe.org/4q3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q3s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q3s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginase\|Arginase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:19, 5 January 2015

OCA — Mon, 05 Jan 2015 14:19:19 GMT

←Older revision		Revision as of 14:19, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
-	[[Category: Christianson, D W.]]	+	[[Category: Christianson, D W]]
-	[[Category: Edwards, J E.]]	+	[[Category: Edwards, J E]]
-	[[Category: Hai, Y.]]	+	[[Category: Hai, Y]]
-	[[Category: Hoffmann, K F.]]	+	[[Category: Hoffmann, K F]]
-	[[Category: Zandt, M C.Van.]]	+	[[Category: Zandt, M C.Van]]
	[[Category: Arginase-deacetylase fold]]		[[Category: Arginase-deacetylase fold]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:42, 23 July 2014

OCA — Wed, 23 Jul 2014 06:42:47 GMT

←Older revision		Revision as of 06:42, 23 July 2014
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	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray crystal structure of arginase from Schistosoma mansoni (SmARG) and the structures of its complexes with several amino acid inhibitors have been determined at atomic resolution. SmARG is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea, and this enzyme is upregulated in all forms of the parasite that interact with the human host. Current hypotheses suggest that parasitic arginases could play a role in host immune evasion by depleting pools of substrate l-arginine that would otherwise be utilized for NO biosynthesis and NO-dependent processes in the immune response. Although the amino acid sequence of SmARG is only 42% identical with that of human arginase I, residues important for substrate binding and catalysis are strictly conserved. In general, classical amino acid inhibitors such as 2(S)-amino-6-boronohexanoic acid (ABH) tend to bind more weakly to SmARG than to human arginase I despite identical inhibitor binding modes in each enzyme active site. The identification of a patch on the enzyme surface capable of accommodating the additional Calpha substitutent of an alpha,alpha-disubstituted amino acid inhibitor suggests that such inhibitors could exhibit higher affinity and biological activity. The structures of SmARG complexed with two different alpha,alpha-disubstituted derivatives of ABH are presented and provide a proof of concept for this approach in the enhancement of enzyme-inhibitor affinity.
		+
		+	Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.,Hai Y, Edwards JE, Van Zandt MC, Hoffmann KF, Christianson DW Biochemistry. 2014 Jul 22;53(28):4671-84. doi: 10.1021/bi5004519. Epub 2014 Jul, 9. PMID:25007099<ref>PMID:25007099</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:32, 16 July 2014

OCA — Wed, 16 Jul 2014 10:32:25 GMT

←Older revision		Revision as of 10:32, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE==
-		+	<StructureSection load='4q3s' size='340' side='right' caption='[[4q3s]], [[Resolution\|resolution]] 2.11Å' scene=''>
-	~~The entry~~ 4q3s is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q3s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q3S FirstGlance]. <br>
-	~~Authors~~: ~~Hai~~, Y., ~~Edwards~~, J.E., ~~Van Zandt~~, M.C., Hoffmann, K.F., ~~Christianson, D~~.W.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q3p\|4q3p]], [[4q3q\|4q3q]], [[4q3r\|4q3r]], [[4q3t\|4q3t]], [[4q3u\|4q3u]], [[4q3v\|4q3v]], [[4q40\|4q40]], [[4q41\|4q41]], [[4q42\|4q42]]</td></tr>
-	~~Description~~: ~~Crystal structure of Schistosoma mansoni arginase in~~ complex ~~with inhibitor ABHPE~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q3s RCSB], [http://www.ebi.ac.uk/pdbsum/4q3s PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arginase]]
		+	[[Category: Christianson, D W.]]
		+	[[Category: Edwards, J E.]]
		+	[[Category: Hai, Y.]]
		+	[[Category: Hoffmann, K F.]]
		+	[[Category: Zandt, M C.Van.]]
		+	[[Category: Arginase-deacetylase fold]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:40, 30 April 2014

OCA — Wed, 30 Apr 2014 06:40:23 GMT

←Older revision		Revision as of 06:40, 30 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q3s is ON HOLD	+	The entry 4q3s is ON HOLD until Paper Publication

	Authors: Hai, Y., Edwards, J.E., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W.		Authors: Hai, Y., Edwards, J.E., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W.

	Description: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE		Description: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE

OCA: Protected "4q3s" [edit=sysop:move=sysop]

OCA — Wed, 23 Apr 2014 07:29:08 GMT

Protected "4q3s" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:29, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q3s is ON HOLD Authors: Hai, Y., Edwards, J.E., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W. Description: Crystal structure of Schistosoma ...

OCA — Wed, 23 Apr 2014 07:29:08 GMT

New page: '''Unreleased structure''' The entry 4q3s is ON HOLD Authors: Hai, Y., Edwards, J.E., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W. Description: Crystal structure of Schistosoma ...

New page

'''Unreleased structure'''

The entry 4q3s is ON HOLD

Authors: Hai, Y., Edwards, J.E., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W.

Description: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE