4q44 - Revision history

OCA at 15:04, 8 November 2023

OCA — Wed, 08 Nov 2023 15:04:14 GMT

←Older revision		Revision as of 15:04, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [https://pdbe.org/4q44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [https://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [https://pdbe.org/4q44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [https://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:43, 8 February 2023

OCA — Wed, 08 Feb 2023 07:43:05 GMT

←Older revision		Revision as of 07:43, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4q44' size='340' side='right'caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='4q44' size='340' side='right'caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [https://pdbe.org/4q44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [https://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [~~http~~://pdbe.org/4q44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPO4_ECOLI DPO4_ECOLI]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.<ref>PMID:9391106</ref> <ref>PMID:11080171</ref> <ref>PMID:11463382</ref> <ref>PMID:11751576</ref> <ref>PMID:12060704</ref>	+	[https://www.uniprot.org/uniprot/DPO4_ECOLI DPO4_ECOLI] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.<ref>PMID:9391106</ref> <ref>PMID:11080171</ref> <ref>PMID:11463382</ref> <ref>PMID:11751576</ref> <ref>PMID:12060704</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[DNA polymerase\|DNA polymerase]]	+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA~~-~~directed DNA polymerase]]~~	+	[[Category: Escherichia coli K-12]]
-	~~[[Category: Ecoli~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kottur, J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Nair, D T~~]]	+	[[Category: Kottur J]]
-	[[Category: ~~Sharma, A~~]]	+	[[Category: Nair DT]]
-	[[Category: ~~Dna]]~~	+	[[Category: Sharma A]]
-	~~[[Category: Dna polymerase]]~~	+
-	~~[[Category: Polymerase]]~~	+
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 09:35, 24 April 2019

OCA — Wed, 24 Apr 2019 09:35:11 GMT

←Older revision		Revision as of 09:35, 24 April 2019
Line 1:		Line 1:

	==Polymerase-Damaged DNA Complex==		==Polymerase-Damaged DNA Complex==
-	<StructureSection load='4q44' size='340' side='right' caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='4q44' size='340' side='right'caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [http://pdbe.org/4q44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [http://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [http://pdbe.org/4q44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [http://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4q44" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4q44" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Kottur, J]]		[[Category: Kottur, J]]
	[[Category: Nair, D T]]		[[Category: Nair, D T]]

OCA at 17:34, 9 March 2017

OCA — Thu, 09 Mar 2017 17:34:06 GMT

←Older revision		Revision as of 17:34, 9 March 2017
Line 1:		Line 1:
		+
	==Polymerase-Damaged DNA Complex==		==Polymerase-Damaged DNA Complex==
	<StructureSection load='4q44' size='340' side='right' caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='4q44' size='340' side='right' caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [http://www.ebi.ac.uk/pdbsum/4q44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [http://pdbe.org/4q44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [http://www.ebi.ac.uk/pdbsum/4q44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q44" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:51, 6 May 2015

OCA — Wed, 06 May 2015 12:51:01 GMT

←Older revision		Revision as of 12:51, 6 May 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Polymerase-Damaged DNA Complex==
		+	<StructureSection load='4q44' size='340' side='right' caption='[[4q44]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4q44]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q44 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q43\|4q43]], [[4q45\|4q45]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q44 RCSB], [http://www.ebi.ac.uk/pdbsum/4q44 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPO4_ECOLI DPO4_ECOLI]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.<ref>PMID:9391106</ref> <ref>PMID:11080171</ref> <ref>PMID:11463382</ref> <ref>PMID:11751576</ref> <ref>PMID:12060704</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reduction in the efficacy of therapeutic antibiotics represents a global problem of increasing intensity and concern. Nitrofuran antibiotics act primarily through the formation of covalent adducts at the N(2) atom of the deoxyguanosine nucleotide in genomic DNA. These adducts inhibit replicative DNA polymerases (dPols), leading to the death of the prokaryote. N(2)-furfuryl-deoxyguanosine (fdG) represents a stable structural analog of the nitrofuran-induced adducts. Unlike other known dPols, DNA polymerase IV (PolIV) from E. coli can bypass the fdG adduct accurately with high catalytic efficiency. This property of PolIV is central to its role in reducing the sensitivity of E. coli toward nitrofuran antibiotics such as nitrofurazone (NFZ). We present the mechanism used by PolIV to bypass NFZ-induced adducts and thus improve viability of E. coli in the presence of NFZ. Our results can be used to develop specific inhibitors of PolIV that may potentiate the activity of nitrofuran antibiotics.

-	~~The entry 4q44 is ON HOLD~~	+	Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic.,Kottur J, Sharma A, Gore KR, Narayanan N, Samanta B, Pradeepkumar PI, Nair DT Structure. 2015 Jan 6;23(1):56-67. doi: 10.1016/j.str.2014.10.019. Epub 2014 Dec , 11. PMID:25497730<ref>PMID:25497730</ref>

-	~~Authors: Nair~~, D.T.~~, Kottur, J., Sharma, A~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Polymerase~~-~~Damaged~~ DNA ~~Complex~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Nair, D.T]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Kottur, J]]
		+	[[Category: Nair, D T]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
-	[[Category: ~~Kottur, J~~]]	+	[[Category: Dna]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Polymerase]]
		+	[[Category: Transferase-dna complex]]

OCA at 15:24, 24 December 2014

OCA — Wed, 24 Dec 2014 15:24:49 GMT

←Older revision		Revision as of 15:24, 24 December 2014
Line 6:		Line 6:

	Description: Polymerase-Damaged DNA Complex		Description: Polymerase-Damaged DNA Complex
		+	[[Category: Unreleased Structures]]
		+	[[Category: Nair, D.T]]
		+	[[Category: Sharma, A]]
		+	[[Category: Kottur, J]]

OCA at 06:40, 30 April 2014

OCA — Wed, 30 Apr 2014 06:40:52 GMT

←Older revision		Revision as of 06:40, 30 April 2014
Line 5:		Line 5:
	Authors: Nair, D.T., Kottur, J., Sharma, A.		Authors: Nair, D.T., Kottur, J., Sharma, A.

-	Description: ~~POLYMERASE~~-~~DAMAGED~~ DNA ~~COMPLEX~~	+	Description: Polymerase-Damaged DNA Complex

OCA: Protected "4q44" [edit=sysop:move=sysop]

OCA — Wed, 23 Apr 2014 07:29:23 GMT

Protected "4q44" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:29, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q44 is ON HOLD Authors: Nair, D.T., Kottur, J., Sharma, A. Description: POLYMERASE-DAMAGED DNA COMPLEX

OCA — Wed, 23 Apr 2014 07:29:23 GMT

New page: '''Unreleased structure''' The entry 4q44 is ON HOLD Authors: Nair, D.T., Kottur, J., Sharma, A. Description: POLYMERASE-DAMAGED DNA COMPLEX

New page

'''Unreleased structure'''

The entry 4q44 is ON HOLD

Authors: Nair, D.T., Kottur, J., Sharma, A.

Description: POLYMERASE-DAMAGED DNA COMPLEX