4q46 - Revision history

OCA at 15:04, 8 November 2023

OCA — Wed, 08 Nov 2023 15:04:16 GMT

←Older revision		Revision as of 15:04, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus Influenza B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus Influenza B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [https://pdbe.org/4q46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [https://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [https://pdbe.org/4q46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [https://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:43, 8 February 2023

OCA — Wed, 08 Feb 2023 07:43:11 GMT

←Older revision		Revision as of 07:43, 8 February 2023
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	<StructureSection load='4q46' size='340' side='right'caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4q46' size='340' side='right'caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9infb 9infb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus Influenza B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [https://pdbe.org/4q46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [https://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [~~http~~://pdbe.org/4q46 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0J9X1Z6_9INFB A0A0J9X1Z6_9INFB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza B virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	[[Category: Zheng, X]]	+	[[Category: Zheng X]]
-	~~[[Category: Cap binding]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:16, 25 December 2019

OCA — Wed, 25 Dec 2019 10:16:04 GMT

←Older revision		Revision as of 10:16, 25 December 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [http://pdbe.org/4q46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [http://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [http://pdbe.org/4q46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [http://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The influenza RNA-dependent RNA polymerase is a core enzyme required for both transcription and replication of the virus RNA genome, making it a potential drug target for the influenza virus. To detect the feature of cap-dependent transcription of influenza B virus (FluB) polymerase, we determined the crystal structures of the wild-type FluB polymerase PB2 subunit cap-binding domain (PB2cap) with bound GDP and the mutant FluB Q325F PB2cap with bound m(7)GDP or GDP. These structures revealed that, distinct from influenza A virus (FluA) PB2cap, the guanine and ribose moieties of substrates invert in FluB PB2caps. Moreover, we characterized the substrate specificity and affinity of the PB2caps using isothermal titration calorimetry. FluB PB2cap has a weaker affinity for m(7)GDP than FluA PB2cap. Unlike FluA PB2cap that has a preference for m(7)GDP in comparison with GDP, FluB PB2cap shows an analogous affinity for both substrates. Replacement of FluB PB2 Glu(325) by Phe, the corresponding residue of FluA PB2, increased the binding affinity of FluB PB2cap for m(7)GDP to a level approximate to that of FluA PB2cap and caused a significant higher affinity to GDP. This study indicated that FluB PB2cap has a unique cap recognition mechanism compared with FluA PB2cap, providing molecular insight into inhibitor design targeting FluB PB2cap.
		+
		+	The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.,Liu Y, Yang Y, Fan J, He R, Luo M, Zheng X J Biol Chem. 2015 Apr 3;290(14):9141-9. doi: 10.1074/jbc.M115.636464. Epub 2015, Feb 17. PMID:25691568<ref>PMID:25691568</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4q46" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:05, 24 April 2019

OCA — Wed, 24 Apr 2019 09:05:46 GMT

←Older revision		Revision as of 09:05, 24 April 2019
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	==The second structure of Influenza B PB2 cap-binding domain complex with GDP==		==The second structure of Influenza B PB2 cap-binding domain complex with GDP==
-	<StructureSection load='4q46' size='340' side='right' caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4q46' size='340' side='right'caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infb 9infb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, Y]]		[[Category: Liu, Y]]
	[[Category: Yang, Y]]		[[Category: Yang, Y]]

OCA at 17:15, 4 January 2017

OCA — Wed, 04 Jan 2017 17:15:26 GMT

←Older revision		Revision as of 17:15, 4 January 2017
Line 1:		Line 1:
		+
	==The second structure of Influenza B PB2 cap-binding domain complex with GDP==		==The second structure of Influenza B PB2 cap-binding domain complex with GDP==
	<StructureSection load='4q46' size='340' side='right' caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4q46' size='340' side='right' caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [http://www.ebi.ac.uk/pdbsum/4q46 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [http://pdbe.org/4q46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [http://www.ebi.ac.uk/pdbsum/4q46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q46 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 14:01, 25 February 2015

OCA — Wed, 25 Feb 2015 14:01:45 GMT

←Older revision		Revision as of 14:01, 25 February 2015
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-	'''~~Unreleased structure~~'''	+	==The second structure of Influenza B PB2 cap-binding domain complex with GDP==
-		+	<StructureSection load='4q46' size='340' side='right' caption='[[4q46]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~The entry~~ 4q46 is ~~ON HOLD until May 10 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q46]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q46 FirstGlance]. <br>
-	~~Authors~~: ~~Liu~~, Y., ~~Yang~~, Y., ~~Zheng, X~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oro\|4oro]], [[4or4\|4or4]], [[4or6\|4or6]]</td></tr>
-	~~Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q46 RCSB], [http://www.ebi.ac.uk/pdbsum/4q46 PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, Y]]
	[[Category: Yang, Y]]		[[Category: Yang, Y]]
	[[Category: Zheng, X]]		[[Category: Zheng, X]]
-	[[Category: ~~Liu, Y~~]]	+	[[Category: Cap binding]]
		+	[[Category: Viral protein]]

OCA at 07:50, 12 February 2015

OCA — Thu, 12 Feb 2015 07:50:15 GMT

←Older revision		Revision as of 07:50, 12 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q46 is ON HOLD until ~~Paper Publication~~	+	The entry 4q46 is ON HOLD until May 10 2016

	Authors: Liu, Y., Yang, Y., Zheng, X.		Authors: Liu, Y., Yang, Y., Zheng, X.

OCA at 15:24, 24 December 2014

OCA — Wed, 24 Dec 2014 15:24:54 GMT

←Older revision		Revision as of 15:24, 24 December 2014
Line 6:		Line 6:

	Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP		Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP
		+	[[Category: Unreleased Structures]]
		+	[[Category: Yang, Y]]
		+	[[Category: Zheng, X]]
		+	[[Category: Liu, Y]]

OCA at 07:48, 7 May 2014

OCA — Wed, 07 May 2014 07:48:18 GMT

←Older revision		Revision as of 07:48, 7 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q46 is ON HOLD	+	The entry 4q46 is ON HOLD until Paper Publication

	Authors: Liu, Y., Yang, Y., Zheng, X.		Authors: Liu, Y., Yang, Y., Zheng, X.

	Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP		Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP

OCA at 06:40, 30 April 2014

OCA — Wed, 30 Apr 2014 06:40:58 GMT

←Older revision		Revision as of 06:40, 30 April 2014
Line 3:		Line 3:
	The entry 4q46 is ON HOLD		The entry 4q46 is ON HOLD

-	Authors: ~~Yong~~ Liu, ~~Yongfeng~~ Yang, ~~Xiaofeng~~ Zheng	+	Authors: Liu, Y., Yang, Y., Zheng, X.

-	Description: ~~the~~ second structure of Influenza B PB2 cap-binding domain complex with GDP	+	Description: The second structure of Influenza B PB2 cap-binding domain complex with GDP