4q4v - Revision history

OCA at 12:44, 1 March 2024

OCA — Fri, 01 Mar 2024 12:44:09 GMT

←Older revision		Revision as of 12:44, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A24 Coxsackievirus A24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A24 Coxsackievirus A24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [https://pdbe.org/4q4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [https://www.ebi.ac.uk/pdbsum/4q4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [https://pdbe.org/4q4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [https://www.ebi.ac.uk/pdbsum/4q4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/V9VEF3_9ENTO V9VEF3_9ENTO]		[https://www.uniprot.org/uniprot/V9VEF3_9ENTO V9VEF3_9ENTO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The picornaviruses coxsackievirus A24 variant (CVA24v) and enterovirus 70 (EV70) cause continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC), a highly contagious eye disease against which neither vaccines nor antiviral drugs are currently available. Moreover, these viruses can cause symptoms in the cornea, upper respiratory tract, and neurological impairments such as acute flaccid paralysis. EV70 and CVA24v are both known to use 5-N-acetylneuraminic acid (Neu5Ac) for cell attachment, thus providing a putative link between the glycan receptor specificity and cell tropism and disease. We report the structures of an intact human picornavirus in complex with a range of glycans terminating in Neu5Ac. We determined the structure of the CVA24v to 1.40 A resolution, screened different glycans bearing Neu5Ac for CVA24v binding, and structurally characterized interactions with candidate glycan receptors. Biochemical studies verified the relevance of the binding site and demonstrated a preference of CVA24v for alpha2,6-linked glycans. This preference can be rationalized by molecular dynamics simulations that show that alpha2,6-linked glycans can establish more contacts with the viral capsid. Our results form an excellent platform for the design of antiviral compounds to prevent AHC.
-
-	A sialic Acid binding site in a human picornavirus.,Zocher G, Mistry N, Frank M, Hahnlein-Schick I, Ekstrom JO, Arnberg N, Stehle T PLoS Pathog. 2014 Oct 16;10(10):e1004401. doi: 10.1371/journal.ppat.1004401., eCollection 2014 Oct. PMID:25329320<ref>PMID:25329320</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4q4v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:43, 8 February 2023

OCA — Wed, 08 Feb 2023 07:43:44 GMT

←Older revision		Revision as of 07:43, 8 February 2023
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	<StructureSection load='4q4v' size='340' side='right'caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4q4v' size='340' side='right'caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Coxsackievirus_a24~~ Coxsackievirus ~~a24~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A24 Coxsackievirus A24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q4w\|4q4w]], [[4q4x\|4q4x]], [[4q4y\|4q4y]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [https://pdbe.org/4q4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [https://www.ebi.ac.uk/pdbsum/4q4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [~~http~~://pdbe.org/4q4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4v ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V9VEF3_9ENTO V9VEF3_9ENTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4q4v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4q4v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coxsackievirus ~~a24~~]]	+	[[Category: Coxsackievirus A24]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Stehle, T]]	+	[[Category: Stehle T]]
-	[[Category: Zocher, G]]	+	[[Category: Zocher G]]
-	~~[[Category: Coxsackievirus a24v]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 09:23, 24 April 2019

OCA — Wed, 24 Apr 2019 09:23:46 GMT

←Older revision		Revision as of 09:23, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of Coxsackievirus A24v==		==Crystal structure of Coxsackievirus A24v==
-	<StructureSection load='4q4v' size='340' side='right' caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4q4v' size='340' side='right'caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a24 Coxsackievirus a24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a24 Coxsackievirus a24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Coxsackievirus a24]]		[[Category: Coxsackievirus a24]]
		+	[[Category: Large Structures]]
	[[Category: Stehle, T]]		[[Category: Stehle, T]]
	[[Category: Zocher, G]]		[[Category: Zocher, G]]
	[[Category: Coxsackievirus a24v]]		[[Category: Coxsackievirus a24v]]
	[[Category: Virus]]		[[Category: Virus]]

OCA at 11:16, 11 August 2016

OCA — Thu, 11 Aug 2016 11:16:20 GMT

←Older revision		Revision as of 11:16, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Coxsackievirus A24v==		==Crystal structure of Coxsackievirus A24v==
	<StructureSection load='4q4v' size='340' side='right' caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4q4v' size='340' side='right' caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a24 Coxsackievirus a24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a24 Coxsackievirus a24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q4w\|4q4w]], [[4q4x\|4q4x]], [[4q4y\|4q4y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q4w\|4q4w]], [[4q4x\|4q4x]], [[4q4y\|4q4y]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [http://www.ebi.ac.uk/pdbsum/4q4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [http://pdbe.org/4q4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [http://www.ebi.ac.uk/pdbsum/4q4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q4v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:20, 25 January 2015

OCA — Sun, 25 Jan 2015 09:20:16 GMT

←Older revision		Revision as of 09:20, 25 January 2015
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Coxsackievirus a24]]		[[Category: Coxsackievirus a24]]
-	[[Category: Stehle, T.]]	+	[[Category: Stehle, T]]
-	[[Category: Zocher, G.]]	+	[[Category: Zocher, G]]
	[[Category: Coxsackievirus a24v]]		[[Category: Coxsackievirus a24v]]
	[[Category: Virus]]		[[Category: Virus]]

OCA at 08:50, 5 November 2014

OCA — Wed, 05 Nov 2014 08:50:35 GMT

←Older revision		Revision as of 08:50, 5 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Coxsackievirus A24v==
		+	<StructureSection load='4q4v' size='340' side='right' caption='[[4q4v]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4q4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a24 Coxsackievirus a24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4V FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q4w\|4q4w]], [[4q4x\|4q4x]], [[4q4y\|4q4y]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q4v RCSB], [http://www.ebi.ac.uk/pdbsum/4q4v PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The picornaviruses coxsackievirus A24 variant (CVA24v) and enterovirus 70 (EV70) cause continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC), a highly contagious eye disease against which neither vaccines nor antiviral drugs are currently available. Moreover, these viruses can cause symptoms in the cornea, upper respiratory tract, and neurological impairments such as acute flaccid paralysis. EV70 and CVA24v are both known to use 5-N-acetylneuraminic acid (Neu5Ac) for cell attachment, thus providing a putative link between the glycan receptor specificity and cell tropism and disease. We report the structures of an intact human picornavirus in complex with a range of glycans terminating in Neu5Ac. We determined the structure of the CVA24v to 1.40 A resolution, screened different glycans bearing Neu5Ac for CVA24v binding, and structurally characterized interactions with candidate glycan receptors. Biochemical studies verified the relevance of the binding site and demonstrated a preference of CVA24v for alpha2,6-linked glycans. This preference can be rationalized by molecular dynamics simulations that show that alpha2,6-linked glycans can establish more contacts with the viral capsid. Our results form an excellent platform for the design of antiviral compounds to prevent AHC.

-	~~The entry 4q4v is ON HOLD until Paper Publication~~	+	A sialic Acid binding site in a human picornavirus.,Zocher G, Mistry N, Frank M, Hahnlein-Schick I, Ekstrom JO, Arnberg N, Stehle T PLoS Pathog. 2014 Oct 16;10(10):e1004401. doi: 10.1371/journal.ppat.1004401., eCollection 2014 Oct. PMID:25329320<ref>PMID:25329320</ref>

-	~~Authors: Zocher~~, G., Stehle, T.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Coxsackievirus a24]]
		+	[[Category: Stehle, T.]]
		+	[[Category: Zocher, G.]]
		+	[[Category: Coxsackievirus a24v]]
		+	[[Category: Virus]]

OCA at 06:32, 18 June 2014

OCA — Wed, 18 Jun 2014 06:32:06 GMT

←Older revision		Revision as of 06:32, 18 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q4v is ON HOLD	+	The entry 4q4v is ON HOLD until Paper Publication

	Authors: Zocher, G., Stehle, T.		Authors: Zocher, G., Stehle, T.

	Description:		Description:

OCA at 06:41, 30 April 2014

OCA — Wed, 30 Apr 2014 06:41:58 GMT

←Older revision		Revision as of 06:41, 30 April 2014
Line 5:		Line 5:
	Authors: Zocher, G., Stehle, T.		Authors: Zocher, G., Stehle, T.

-	Description: ~~Crystal structure projectX~~	+	Description:

OCA: Protected "4q4v" [edit=sysop:move=sysop]

OCA — Wed, 23 Apr 2014 07:29:57 GMT

Protected "4q4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:29, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q4v is ON HOLD Authors: Zocher, G., Stehle, T. Description: Crystal structure projectX

OCA — Wed, 23 Apr 2014 07:29:56 GMT

New page: '''Unreleased structure''' The entry 4q4v is ON HOLD Authors: Zocher, G., Stehle, T. Description: Crystal structure projectX

New page

'''Unreleased structure'''

The entry 4q4v is ON HOLD

Authors: Zocher, G., Stehle, T.

Description: Crystal structure projectX