4q6s - Revision history

OCA at 17:28, 20 September 2023

OCA — Wed, 20 Sep 2023 17:28:45 GMT

←Older revision		Revision as of 17:28, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [https://pdbe.org/4q6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [https://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [https://pdbe.org/4q6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [https://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:45, 8 February 2023

OCA — Wed, 08 Feb 2023 07:45:38 GMT

←Older revision		Revision as of 07:45, 8 February 2023
Line 1:		Line 1:

	==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==		==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
-	<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4q6s' size='340' side='right'caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [https://pdbe.org/4q6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [https://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GOPC, CAL, FIG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [~~http~~://pdbe.org/4q6s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>	+	[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>	+	[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Amacher, J F~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Madden, D R~~]]	+	[[Category: Amacher JF]]
-	[[Category: ~~Pdz-peptide complex]]~~	+	[[Category: Madden DR]]
-	~~[[Category: Transport protein~~]]	+

OCA at 08:49, 22 November 2017

OCA — Wed, 22 Nov 2017 08:49:56 GMT

←Older revision		Revision as of 08:49, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GOPC, CAL, FIG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://pdbe.org/4q6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://pdbe.org/4q6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>
	</table>		</table>
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Amacher, J F]]		[[Category: Amacher, J F]]
	[[Category: Madden, D R]]		[[Category: Madden, D R]]
	[[Category: Pdz-peptide complex]]		[[Category: Pdz-peptide complex]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 18:38, 1 February 2017

OCA — Wed, 01 Feb 2017 18:38:39 GMT

←Older revision		Revision as of 18:38, 1 February 2017
Line 1:		Line 1:
		+
	==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==		==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
	<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://pdbe.org/4q6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6s ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 11:33, 30 April 2015

OCA — Thu, 30 Apr 2015 11:33:27 GMT

←Older revision		Revision as of 11:33, 30 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
-		+	<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~The entry~~ 4q6s is ~~ON HOLD until Apr 29 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
-	~~Authors~~: ~~Amacher~~, J.F., ~~Madden~~, D.R.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jof\|4jof]]</td></tr>
-	~~Description~~: ~~CFTR Associated Ligand~~ (~~CAL~~) ~~PDZ bound to biotinylated peptide BT~~-~~L-iCAL36~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Amacher, J.F]]	+	== Disease ==
-	[[Category: Madden, D.R]]	+	[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Amacher, J F]]
		+	[[Category: Madden, D R]]
		+	[[Category: Pdz-peptide complex]]
		+	[[Category: Transport protein]]

OCA at 06:40, 8 April 2015

OCA — Wed, 08 Apr 2015 06:40:08 GMT

←Older revision		Revision as of 06:40, 8 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q6s is ON HOLD until ~~Paper Publication~~	+	The entry 4q6s is ON HOLD until Apr 29 2016

	Authors: Amacher, J.F., Madden, D.R.		Authors: Amacher, J.F., Madden, D.R.

OCA at 15:27, 24 December 2014

OCA — Wed, 24 Dec 2014 15:27:14 GMT

←Older revision		Revision as of 15:27, 24 December 2014
Line 6:		Line 6:

	Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36		Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36
		+	[[Category: Unreleased Structures]]
		+	[[Category: Amacher, J.F]]
		+	[[Category: Madden, D.R]]

OCA at 06:32, 18 June 2014

OCA — Wed, 18 Jun 2014 06:32:50 GMT

←Older revision		Revision as of 06:32, 18 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q6s is ON HOLD	+	The entry 4q6s is ON HOLD until Paper Publication

	Authors: Amacher, J.F., Madden, D.R.		Authors: Amacher, J.F., Madden, D.R.

	Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36		Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36

OCA: Protected "4q6s" [edit=sysop:move=sysop]

OCA — Wed, 30 Apr 2014 06:44:57 GMT

Protected "4q6s" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 30 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q6s is ON HOLD Authors: Amacher, J.F., Madden, D.R. Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36

OCA — Wed, 30 Apr 2014 06:44:55 GMT

New page: '''Unreleased structure''' The entry 4q6s is ON HOLD Authors: Amacher, J.F., Madden, D.R. Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36

New page

'''Unreleased structure'''

The entry 4q6s is ON HOLD

Authors: Amacher, J.F., Madden, D.R.

Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36