4q7h - Revision history

OCA at 07:47, 8 February 2023

OCA — Wed, 08 Feb 2023 07:47:01 GMT

←Older revision		Revision as of 07:47, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4q7h' size='340' side='right'caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4q7h' size='340' side='right'caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q7h]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q7h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q7H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [https://pdbe.org/4q7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [https://www.ebi.ac.uk/pdbsum/4q7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7h ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAMHD1, MOP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [~~http~~://pdbe.org/4q7h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q7h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN]] Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) [MIM:[~~http~~://omim.org/entry/612952 612952]]. A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.<ref>PMID:19525956</ref> <ref>PMID:20842748</ref> Defects in SAMHD1 are the cause of chilblain lupus type 2 (CHBL2) [MIM:[~~http~~://omim.org/entry/614415 614415]]. A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade.<ref>PMID:21204240</ref>	+	[https://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN] Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) [MIM:[https://omim.org/entry/612952 612952]. A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.<ref>PMID:19525956</ref> <ref>PMID:20842748</ref> Defects in SAMHD1 are the cause of chilblain lupus type 2 (CHBL2) [MIM:[https://omim.org/entry/614415 614415]. A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade.<ref>PMID:21204240</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN]] Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.<ref>PMID:18546154</ref> <ref>PMID:19525956</ref>	+	[https://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN] Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.<ref>PMID:18546154</ref> <ref>PMID:19525956</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jia, K]]	+	[[Category: Jia K]]
-	[[Category: Xiaofang, Y]]	+	[[Category: Xiaofang Y]]
-	[[Category: Xiaohong, Q]]	+	[[Category: Xiaohong Q]]
-	[[Category: Yanhong, L]]	+	[[Category: Yanhong L]]
-	~~[[Category: Dntp binding]]~~	+
-	~~[[Category: Gtp]]~~	+
-	~~[[Category: Hd-domain]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Protein-gtp complex~~]]	+

OCA at 09:22, 24 April 2019

OCA — Wed, 24 Apr 2019 09:22:34 GMT

←Older revision		Revision as of 09:22, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of SAMHD1 catalytic core with GTP==		==Crystal structure of SAMHD1 catalytic core with GTP==
-	<StructureSection load='4q7h' size='340' side='right' caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='4q7h' size='340' side='right'caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q7h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q7h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAMHD1, MOP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [http://pdbe.org/4q7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [http://www.ebi.ac.uk/pdbsum/4q7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [http://pdbe.org/4q7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [http://www.ebi.ac.uk/pdbsum/4q7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7h ProSAT]</span></td></tr>
	</table>		</table>
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jia, K]]		[[Category: Jia, K]]
	[[Category: Xiaofang, Y]]		[[Category: Xiaofang, Y]]

OCA at 17:26, 9 March 2017

OCA — Thu, 09 Mar 2017 17:26:33 GMT

←Older revision		Revision as of 17:26, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of SAMHD1 catalytic core with GTP==		==Crystal structure of SAMHD1 catalytic core with GTP==
	<StructureSection load='4q7h' size='340' side='right' caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4q7h' size='340' side='right' caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [http://www.ebi.ac.uk/pdbsum/4q7h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [http://pdbe.org/4q7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [http://www.ebi.ac.uk/pdbsum/4q7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7h ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 15:56, 27 May 2015

OCA — Wed, 27 May 2015 15:56:36 GMT

←Older revision		Revision as of 15:56, 27 May 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of SAMHD1 catalytic core with GTP==
-		+	<StructureSection load='4q7h' size='340' side='right' caption='[[4q7h]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~The entry~~ 4q7h is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q7h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7H FirstGlance]. <br>
-	~~Authors~~: ~~Xiaohong~~, Q., ~~Yanhong~~, L., ~~Jia~~, K., ~~Xiaofang, Y~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4bzb\|4bzb]], [[4bzc\|4bzc]], [[4mz7\|4mz7]], [[3u1n\|3u1n]]</td></tr>
-	~~Description~~: ~~Crystal structure of~~ the ~~intermediate~~ form of SAMHD1 ~~catalytic core~~ with ~~GTP~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q7h RCSB], [http://www.ebi.ac.uk/pdbsum/4q7h PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN]] Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) [MIM:[http://omim.org/entry/612952 612952]]. A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.<ref>PMID:19525956</ref> <ref>PMID:20842748</ref> Defects in SAMHD1 are the cause of chilblain lupus type 2 (CHBL2) [MIM:[http://omim.org/entry/614415 614415]]. A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade.<ref>PMID:21204240</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN]] Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.<ref>PMID:18546154</ref> <ref>PMID:19525956</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Jia, K]]		[[Category: Jia, K]]
-	[[Category: Yanhong, L]]
	[[Category: Xiaofang, Y]]		[[Category: Xiaofang, Y]]
	[[Category: Xiaohong, Q]]		[[Category: Xiaohong, Q]]
		+	[[Category: Yanhong, L]]
		+	[[Category: Dntp binding]]
		+	[[Category: Gtp]]
		+	[[Category: Hd-domain]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Protein-gtp complex]]

OCA at 15:27, 24 December 2014

OCA — Wed, 24 Dec 2014 15:27:45 GMT

←Older revision		Revision as of 15:27, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of the intermediate form of SAMHD1 catalytic core with GTP		Description: Crystal structure of the intermediate form of SAMHD1 catalytic core with GTP
		+	[[Category: Unreleased Structures]]
		+	[[Category: Jia, K]]
		+	[[Category: Yanhong, L]]
		+	[[Category: Xiaofang, Y]]
		+	[[Category: Xiaohong, Q]]

OCA at 07:10, 14 May 2014

OCA — Wed, 14 May 2014 07:10:03 GMT

←Older revision		Revision as of 07:10, 14 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q7h is ON HOLD	+	The entry 4q7h is ON HOLD until Paper Publication

-	Authors: ~~Qin~~ Xiaohong, Li Yanhong, ~~Kong jia~~, Yu Xiaofang	+	Authors: Xiaohong, Q., Yanhong, L., Jia, K., Xiaofang, Y.

-	Description: Crystal structure of ~~apo-formed~~ SAMHD1 catalytic core	+	Description: Crystal structure of the intermediate form of SAMHD1 catalytic core with GTP

OCA: Protected "4q7h" [edit=sysop:move=sysop]

OCA — Wed, 30 Apr 2014 06:46:36 GMT

Protected "4q7h" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 30 April 2014

OCA: New page: '''Unreleased structure''' The entry 4q7h is ON HOLD Authors: Qin Xiaohong, Li Yanhong, Kong jia, Yu Xiaofang Description: Crystal structure of apo-formed SAMHD1 catalytic core

OCA — Wed, 30 Apr 2014 06:46:35 GMT

New page: '''Unreleased structure''' The entry 4q7h is ON HOLD Authors: Qin Xiaohong, Li Yanhong, Kong jia, Yu Xiaofang Description: Crystal structure of apo-formed SAMHD1 catalytic core

New page

'''Unreleased structure'''

The entry 4q7h is ON HOLD

Authors: Qin Xiaohong, Li Yanhong, Kong jia, Yu Xiaofang

Description: Crystal structure of apo-formed SAMHD1 catalytic core