4q8h - Revision history

OCA at 17:29, 20 September 2023

OCA — Wed, 20 Sep 2023 17:29:32 GMT

←Older revision		Revision as of 17:29, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [https://pdbe.org/4q8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [https://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [https://pdbe.org/4q8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [https://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:48, 8 February 2023

OCA — Wed, 08 Feb 2023 07:48:11 GMT

←Older revision		Revision as of 07:48, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4q8h' size='340' side='right'caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4q8h' size='340' side='right'caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [https://pdbe.org/4q8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [https://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAN2, YGL094C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [~~http~~://pdbe.org/4q8h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PAN2_YEAST PAN2_YEAST]] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.<ref>PMID:8550599</ref> <ref>PMID:1358757</ref> <ref>PMID:8816488</ref> <ref>PMID:9774670</ref> <ref>PMID:11239395</ref> <ref>PMID:11953437</ref> <ref>PMID:15630021</ref> <ref>PMID:15894541</ref>	+	[https://www.uniprot.org/uniprot/PAN2_YEAST PAN2_YEAST] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.<ref>PMID:8550599</ref> <ref>PMID:1358757</ref> <ref>PMID:8816488</ref> <ref>PMID:9774670</ref> <ref>PMID:11239395</ref> <ref>PMID:11953437</ref> <ref>PMID:15630021</ref> <ref>PMID:15894541</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Conti, E~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Schaefer, I B~~]]	+	[[Category: Conti E]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Schaefer IB]]
-	~~[[Category: Pan3]]~~	+
-	~~[[Category: Rnase]]~~	+
-	~~[[Category: Ubiquitin carboxyl-terminal hydrolase-like domain]]~~	+
-	~~[[Category: Uch~~]]	+

OCA at 08:58, 24 April 2019

OCA — Wed, 24 Apr 2019 08:58:57 GMT

←Older revision		Revision as of 08:58, 24 April 2019
Line 1:		Line 1:

	==Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module==		==Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module==
-	<StructureSection load='4q8h' size='340' side='right' caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='4q8h' size='340' side='right'caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAN2, YGL094C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://pdbe.org/4q8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://pdbe.org/4q8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Conti, E]]		[[Category: Conti, E]]
	[[Category: Schaefer, I B]]		[[Category: Schaefer, I B]]

OCA at 18:37, 5 August 2016

OCA — Fri, 05 Aug 2016 18:37:31 GMT

←Older revision		Revision as of 18:37, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module==		==Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module==
	<StructureSection load='4q8h' size='340' side='right' caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4q8h' size='340' side='right' caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://pdbe.org/4q8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q8h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q8h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:01, 25 December 2014

OCA — Thu, 25 Dec 2014 21:01:52 GMT

←Older revision		Revision as of 21:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAN2_YEAST PAN2_YEAST]] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.<ref>PMID:8550599</ref> <ref>PMID:1358757</ref> <ref>PMID:8816488</ref> <ref>PMID:9774670</ref> <ref>PMID:11239395</ref> <ref>PMID:11953437</ref> <ref>PMID:15630021</ref> <ref>PMID:15894541</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Conti, E.]]	+	[[Category: Conti, E]]
-	[[Category: Schaefer, I B.]]	+	[[Category: Schaefer, I B]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pan3]]		[[Category: Pan3]]

OCA at 06:17, 2 July 2014

OCA — Wed, 02 Jul 2014 06:17:56 GMT

←Older revision		Revision as of 06:17, 2 July 2014
Line 8:		Line 8:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pan2-Pan3 is a conserved complex involved in the shortening of mRNA poly(A) tails, the initial step in eukaryotic mRNA turnover. We show that recombinant Saccharomyces cerevisiae Pan2-Pan3 can deadenylate RNAs in vitro without needing the poly(A)-binding protein Pab1. The crystal structure of an active ~200-kDa core complex reveals that Pan2 and Pan3 interact with an unusual 1:2 stoichiometry imparted by the asymmetric nature of the Pan3 homodimer. An extended region of Pan2 wraps around Pan3 and provides a major anchoring point for complex assembly. A Pan2 module formed by the pseudoubiquitin-hydrolase and RNase domains latches onto the Pan3 pseudokinase with intertwined interactions that orient the deadenylase active site toward the A-binding site of the interacting Pan3. The molecular architecture of Pan2-Pan3 suggests how the nuclease and its pseudokinase regulator act in synergy to promote deadenylation.
		+
		+	The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.,Schafer IB, Rode M, Bonneau F, Schussler S, Conti E Nat Struct Mol Biol. 2014 Jun 1. doi: 10.1038/nsmb.2834. PMID:24880344<ref>PMID:24880344</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:15, 4 June 2014

OCA — Wed, 04 Jun 2014 05:15:09 GMT

←Older revision		Revision as of 05:15, 4 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module==
-		+	<StructureSection load='4q8h' size='340' side='right' caption='[[4q8h]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~The entry~~ 4q8h is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q8H FirstGlance]. <br>
-	~~Authors~~: ~~Schaefer~~, I.B., Conti, E.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q8g\|4q8g]], [[4q8j\|4q8j]]</td></tr>
-	~~Description~~: ~~Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin~~-hydrolase-~~RNase module~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q8h RCSB], [http://www.ebi.ac.uk/pdbsum/4q8h PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Conti, E.]]
		+	[[Category: Schaefer, I B.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pan3]]
		+	[[Category: Rnase]]
		+	[[Category: Ubiquitin carboxyl-terminal hydrolase-like domain]]
		+	[[Category: Uch]]

OCA at 08:14, 21 May 2014

OCA — Wed, 21 May 2014 08:14:57 GMT

←Older revision		Revision as of 08:14, 21 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q8h is ON HOLD	+	The entry 4q8h is ON HOLD until Paper Publication

	Authors: Schaefer, I.B., Conti, E.		Authors: Schaefer, I.B., Conti, E.

	Description: Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module		Description: Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module

OCA: Protected "4q8h" [edit=sysop:move=sysop]

OCA — Wed, 07 May 2014 07:50:49 GMT

Protected "4q8h" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:50, 7 May 2014

OCA: New page: '''Unreleased structure''' The entry 4q8h is ON HOLD Authors: Schaefer, I.B., Conti, E. Description: Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase modu...

OCA — Wed, 07 May 2014 07:50:49 GMT

New page: '''Unreleased structure''' The entry 4q8h is ON HOLD Authors: Schaefer, I.B., Conti, E. Description: Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase modu...

New page

'''Unreleased structure'''

The entry 4q8h is ON HOLD

Authors: Schaefer, I.B., Conti, E.

Description: Structure of the Saccharomyces cerevisiae PAN2 pseudoubiquitin-hydrolase-RNase module