4q93 - Revision history

OCA at 17:29, 20 September 2023

OCA — Wed, 20 Sep 2023 17:29:54 GMT

←Older revision		Revision as of 17:29, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [https://pdbe.org/4q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [https://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [https://pdbe.org/4q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [https://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:18, 15 February 2023

OCA — Wed, 15 Feb 2023 11:18:36 GMT

←Older revision		Revision as of 11:18, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4q93' size='340' side='right'caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4q93' size='340' side='right'caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [https://pdbe.org/4q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [https://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [~~http~~://pdbe.org/4q93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[~~http~~://omim.org/entry/608323 608323]]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>	+	[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[https://omim.org/entry/608323 608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).	+	[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Tyrosine--tRNA ligase]]~~	+	[[Category: Mathew S]]
-	[[Category: Mathew, S]]	+	[[Category: Schimmel P]]
-	[[Category: Schimmel, P]]	+
-	~~[[Category: Active site]]~~	+
-	~~[[Category: Amino acid activation]]~~	+
-	~~[[Category: Aminoacyl trna synthetase]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Resveratrol~~]]	+

OCA at 09:45, 24 April 2019

OCA — Wed, 24 Apr 2019 09:45:12 GMT

←Older revision		Revision as of 09:45, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of resveratrol bound human tyrosyl tRNA synthetase==		==Crystal structure of resveratrol bound human tyrosyl tRNA synthetase==
-	<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4q93' size='340' side='right'caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://pdbe.org/4q93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://pdbe.org/4q93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>
Line 22:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4q93" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4q93" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Tyrosine--tRNA ligase]]		[[Category: Tyrosine--tRNA ligase]]
	[[Category: Mathew, S]]		[[Category: Mathew, S]]

OCA at 17:17, 4 January 2017

OCA — Wed, 04 Jan 2017 17:17:21 GMT

←Older revision		Revision as of 17:17, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of resveratrol bound human tyrosyl tRNA synthetase==		==Crystal structure of resveratrol bound human tyrosyl tRNA synthetase==
	<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://pdbe.org/4q93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q93 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q93" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 14 January 2015

OCA — Wed, 14 Jan 2015 08:27:52 GMT

←Older revision		Revision as of 08:27, 14 January 2015
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).		[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Resveratrol is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects by initiating a stress response that induces survival genes. Because human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS) translocates to the nucleus under stress conditions, we considered the possibility that the tyrosine-like phenolic ring of resveratrol might fit into the active site pocket to effect a nuclear role. Here we present a 2.1 A co-crystal structure of resveratrol bound to the active site of TyrRS. Resveratrol nullifies the catalytic activity and redirects TyrRS to a nuclear function, stimulating NAD+-dependent auto-poly-ADP-ribosylation of poly(ADP-ribose) polymerase 1 (PARP1). Downstream activation of key stress signalling pathways are causally connected to TyrRS-PARP1-NAD+ collaboration. This collaboration is also demonstrated in the mouse, and is specifically blocked in vivo by a resveratrol-displacing tyrosyl adenylate analogue. In contrast to functionally diverse tRNA synthetase catalytic nulls created by alternative splicing events that ablate active sites, here a non-spliced TyrRS catalytic null reveals a new PARP1- and NAD+-dependent dimension to the physiological mechanism of resveratrol.
		+
		+	A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.,Sajish M, Schimmel P Nature. 2014 Dec 22. doi: 10.1038/nature14028. PMID:25533949<ref>PMID:25533949</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:27, 24 December 2014

OCA — Wed, 24 Dec 2014 11:27:54 GMT

←Older revision		Revision as of 11:27, 24 December 2014
Line 1:		Line 1:
-	==~~Resveratrol bound at the active site~~ of human tyrosyl tRNA synthetase==	+	==Crystal structure of resveratrol bound human tyrosyl tRNA synthetase==
	<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:57, 17 December 2014

OCA — Wed, 17 Dec 2014 12:57:43 GMT

←Older revision		Revision as of 12:57, 17 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Resveratrol bound at the active site of human tyrosyl tRNA synthetase==
-		+	<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 4q93 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>
-	~~Authors~~: ~~Mathew~~, S., ~~Schimmel~~, P.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q11\|1q11]], [[1n3l\|1n3l]], [[4qbt\|4qbt]]</td></tr>
-	~~Description~~: ~~Resveratrol bound at~~ the ~~active site~~ of ~~human tyrosyl~~ tRNA synthetase	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[http://omim.org/entry/608323 608323]]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Tyrosine--tRNA ligase]]
		+	[[Category: Mathew, S]]
		+	[[Category: Schimmel, P]]
		+	[[Category: Active site]]
		+	[[Category: Amino acid activation]]
		+	[[Category: Aminoacyl trna synthetase]]
		+	[[Category: Ligase]]
		+	[[Category: Resveratrol]]

OCA at 08:15, 21 May 2014

OCA — Wed, 21 May 2014 08:15:12 GMT

←Older revision		Revision as of 08:15, 21 May 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4q93 is ON HOLD	+	The entry 4q93 is ON HOLD until Paper Publication

	Authors: Mathew, S., Schimmel, P.		Authors: Mathew, S., Schimmel, P.

	Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase		Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase

OCA: Protected "4q93" [edit=sysop:move=sysop]

OCA — Wed, 07 May 2014 07:51:33 GMT

Protected "4q93" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 7 May 2014

OCA: New page: '''Unreleased structure''' The entry 4q93 is ON HOLD Authors: Mathew, S., Schimmel, P. Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase

OCA — Wed, 07 May 2014 07:51:32 GMT

New page: '''Unreleased structure''' The entry 4q93 is ON HOLD Authors: Mathew, S., Schimmel, P. Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase

New page

'''Unreleased structure'''

The entry 4q93 is ON HOLD

Authors: Mathew, S., Schimmel, P.

Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase