4q94 - Revision history

OCA at 17:29, 20 September 2023

OCA — Wed, 20 Sep 2023 17:29:55 GMT

←Older revision		Revision as of 17:29, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [https://pdbe.org/4q94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [https://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [https://pdbe.org/4q94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [https://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:18, 15 February 2023

OCA — Wed, 15 Feb 2023 11:18:38 GMT

←Older revision		Revision as of 11:18, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4q94' size='340' side='right'caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4q94' size='340' side='right'caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [https://pdbe.org/4q94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [https://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class="sblockDat">[[4q96\|4q96]]</td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">RPRD1B, C20orf77, CREPT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [~~http~~://pdbe.org/4q94 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RPR1B_HUMAN RPR1B_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.<ref>PMID:22264791</ref> <ref>PMID:22231121</ref>	+	[https://www.uniprot.org/uniprot/RPR1B_HUMAN RPR1B_HUMAN] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.<ref>PMID:22264791</ref> <ref>PMID:22231121</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Bakkouri, M El~~]]	+	[[Category: Bountra C]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Edwards AM]]
-	[[Category: ~~Edwards, A~~ M]]	+	[[Category: El Bakkouri M]]
-	[[Category: Greenblatt~~, J F~~]]	+	[[Category: Greenblatt JF]]
-	[[Category: Loppnau, P]]	+	[[Category: Loppnau P]]
-	[[Category: Min, J]]	+	[[Category: Min J]]
-	[[Category: Ni, Z]]	+	[[Category: Ni Z]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Tempel W]]
-	[[Category: Tempel, W]]	+	[[Category: Xu C]]
-	[[Category: Xu, C]]	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 09:07, 24 April 2019

OCA — Wed, 24 Apr 2019 09:07:28 GMT

←Older revision		Revision as of 09:07, 24 April 2019
Line 1:		Line 1:

	==human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide==		==human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide==
-	<StructureSection load='4q94' size='340' side='right' caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4q94' size='340' side='right'caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPRD1B, C20orf77, CREPT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://pdbe.org/4q94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://pdbe.org/4q94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bakkouri, M El]]		[[Category: Bakkouri, M El]]
Line 36:		Line 39:
	[[Category: Xu, C]]		[[Category: Xu, C]]
	[[Category: Peptide binding protein]]		[[Category: Peptide binding protein]]
		+	[[Category: Sgc]]

OCA at 01:49, 5 August 2016

OCA — Fri, 05 Aug 2016 01:49:32 GMT

←Older revision		Revision as of 01:49, 5 August 2016
Line 1:		Line 1:
		+
	==human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide==		==human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide==
	<StructureSection load='4q94' size='340' side='right' caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4q94' size='340' side='right' caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://pdbe.org/4q94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q94 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4q94" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:44, 24 December 2014

OCA — Wed, 24 Dec 2014 21:44:57 GMT

←Older revision		Revision as of 21:44, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RPR1B_HUMAN RPR1B_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.<ref>PMID:22264791</ref> <ref>PMID:22231121</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bakkouri, M El.]]	+	[[Category: Bakkouri, M El]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Greenblatt, J F.]]	+	[[Category: Greenblatt, J F]]
-	[[Category: Loppnau, P.]]	+	[[Category: Loppnau, P]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: Ni, Z.]]	+	[[Category: Ni, Z]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Xu, C.]]	+	[[Category: Xu, C]]
	[[Category: Peptide binding protein]]		[[Category: Peptide binding protein]]

OCA at 06:39, 30 July 2014

OCA — Wed, 30 Jul 2014 06:39:21 GMT

←Older revision		Revision as of 06:39, 30 July 2014
Line 8:		Line 8:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The RNA polymerase II (RNAPII) C-terminal domain (CTD) heptapeptide repeats (1-YSPTSPS-7) undergo dynamic phosphorylation and dephosphorylation during the transcription cycle to recruit factors that regulate transcription, RNA processing and chromatin modification. We show here that RPRD1A and RPRD1B form homodimers and heterodimers through their coiled-coil domains and interact preferentially via CTD-interaction domains (CIDs) with RNAPII CTD repeats phosphorylated at S2 and S7. Crystal structures of the RPRD1A, RPRD1B and RPRD2 CIDs, alone and in complex with RNAPII CTD phosphoisoforms, elucidate the molecular basis of CTD recognition. In an example of cross-talk between different CTD modifications, our data also indicate that RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and, by interacting with CTD repeats where phospho-S2 and/or phospho-S7 bracket a phospho-S5 residue, serve as CTD scaffolds to coordinate the dephosphorylation of phospho-S5 by RPAP2.
		+
		+	RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.,Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF Nat Struct Mol Biol. 2014 Jul 6. doi: 10.1038/nsmb.2853. PMID:24997600<ref>PMID:24997600</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:23, 18 June 2014

OCA — Wed, 18 Jun 2014 08:23:12 GMT

←Older revision		Revision as of 08:23, 18 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide==
-		+	<StructureSection load='4q94' size='340' side='right' caption='[[4q94]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~The entry~~ 4q94 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4q94]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q94 FirstGlance]. <br>
-	~~Authors~~: Ni, Z., ~~Xu, C~~.~~, Tempel, W~~.~~, El Bakkouri, M~~., ~~Loppnau, P~~., ~~Bountra, C~~., Arrowsmith, C.H., Edwards, A.M.~~, Min~~, J., ~~Greenblatt~~, J.F., Structural Genomics Consortium ~~(SGC)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~Description~~: ~~human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q96\|4q96]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q94 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q94 RCSB], [http://www.ebi.ac.uk/pdbsum/4q94 PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bakkouri, M El.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Greenblatt, J F.]]
		+	[[Category: Loppnau, P.]]
		+	[[Category: Min, J.]]
		+	[[Category: Ni, Z.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Xu, C.]]
		+	[[Category: Peptide binding protein]]

OCA at 07:10, 14 May 2014

OCA — Wed, 14 May 2014 07:10:17 GMT

←Older revision		Revision as of 07:10, 14 May 2014
Line 3:		Line 3:
	The entry 4q94 is ON HOLD		The entry 4q94 is ON HOLD

-	Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)	+	Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)

	Description: human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide		Description: human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide

OCA: Protected "4q94" [edit=sysop:move=sysop]

OCA — Wed, 07 May 2014 07:51:35 GMT

Protected "4q94" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 7 May 2014

OCA: New page: '''Unreleased structure''' The entry 4q94 is ON HOLD Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Greenbla...

OCA — Wed, 07 May 2014 07:51:34 GMT

New page: '''Unreleased structure''' The entry 4q94 is ON HOLD Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Greenbla...

New page

'''Unreleased structure'''

The entry 4q94 is ON HOLD

Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)

Description: human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide