4qec - Revision history

OCA at 12:45, 1 March 2024

OCA — Fri, 01 Mar 2024 12:45:50 GMT

←Older revision		Revision as of 12:45, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [https://pdbe.org/4qec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [https://www.ebi.ac.uk/pdbsum/4qec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [https://pdbe.org/4qec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [https://www.ebi.ac.uk/pdbsum/4qec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/I6ZQW6_STAEP I6ZQW6_STAEP]		[https://www.uniprot.org/uniprot/I6ZQW6_STAEP I6ZQW6_STAEP]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The final step in lanthipeptide biosynthesis involves the proteolytic removal of an N-terminal leader peptide. In the class I lanthipeptide epilancin 15X, this step is performed by the subtilisin-like serine peptidase ElxP. Bioinformatic, kinetic, and mass spectrometric analysis revealed that ElxP recognizes the stretch of amino acids DLNPQS located near the proteolytic cleavage site of its substrate, ElxA. When the ElxP recognition motif was inserted into the noncognate lanthipeptide precursor NisA, ElxP was able to proteolytically remove the leader peptide from NisA. Proteolytic removal of the leader peptide by ElxP during the biosynthesis of epilancin 15X exposes an N-terminal dehydroalanine on the core peptide of ElxA that hydrolyzes to a pyruvyl group. The short-chain dehydrogenase ElxO reduces the pyruvyl group to a lactyl moiety in the final step of epilancin 15X maturation. Using synthetic peptides, we also investigated the substrate specificity of ElxO and determined the 1.85 A resolution X-ray crystal structure of the enzyme.
-
-	Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO.,Ortega MA, Velasquez JE, Garg N, Zhang Q, Joyce RE, Nair SK, van der Donk WA ACS Chem Biol. 2014 Jun 6. PMID:24866416<ref>PMID:24866416</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4qec" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:25, 15 February 2023

OCA — Wed, 15 Feb 2023 11:25:35 GMT

←Older revision		Revision as of 11:25, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4qec' size='340' side='right'caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4qec' size='340' side='right'caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"albococcus_epidermidis"_winslow_and_winslow_1908 "albococcus~~ epidermidis~~" winslow and winslow 1908~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [https://pdbe.org/4qec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [https://www.ebi.ac.uk/pdbsum/4qec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">elxO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1282 "Albococcus epidermidis" Winslow and Winslow 1908])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [~~http~~://pdbe.org/4qec PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qec PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/I6ZQW6_STAEP I6ZQW6_STAEP]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Albococcus epidermidis winslow and winslow 1908]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Garg, N~~]]	+	[[Category: Staphylococcus epidermidis]]
-	[[Category: ~~Nair, S K~~]]	+	[[Category: Garg N]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Nair SK]]
-	~~[[Category: Rossmann fold~~]]	+

OCA at 09:00, 24 April 2019

OCA — Wed, 24 Apr 2019 09:00:45 GMT

←Older revision		Revision as of 09:00, 24 April 2019
Line 1:		Line 1:

	==ElxO with NADP Bound==		==ElxO with NADP Bound==
-	<StructureSection load='4qec' size='340' side='right' caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4qec' size='340' side='right'caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"albococcus_epidermidis"_winslow_and_winslow_1908 "albococcus epidermidis" winslow and winslow 1908]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">elxO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1282 "Albococcus epidermidis" Winslow and Winslow 1908])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://pdbe.org/4qec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://pdbe.org/4qec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Albococcus epidermidis winslow and winslow 1908]]
		+	[[Category: Large Structures]]
	[[Category: Garg, N]]		[[Category: Garg, N]]
	[[Category: Nair, S K]]		[[Category: Nair, S K]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 09:16, 11 August 2016

OCA — Thu, 11 Aug 2016 09:16:30 GMT

←Older revision		Revision as of 09:16, 11 August 2016
Line 1:		Line 1:
		+
	==ElxO with NADP Bound==		==ElxO with NADP Bound==
	<StructureSection load='4qec' size='340' side='right' caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4qec' size='340' side='right' caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://pdbe.org/4qec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qec ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qec" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:30, 5 January 2015

OCA — Mon, 05 Jan 2015 14:30:33 GMT

←Older revision		Revision as of 14:30, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Garg, N.]]	+	[[Category: Garg, N]]
-	[[Category: Nair, S K.]]	+	[[Category: Nair, S K]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 08:28, 2 July 2014

OCA — Wed, 02 Jul 2014 08:28:04 GMT

←Older revision		Revision as of 08:28, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==ElxO with NADP Bound==
		+	<StructureSection load='4qec' size='340' side='right' caption='[[4qec]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qec]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qed\|4qed]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qec RCSB], [http://www.ebi.ac.uk/pdbsum/4qec PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The final step in lanthipeptide biosynthesis involves the proteolytic removal of an N-terminal leader peptide. In the class I lanthipeptide epilancin 15X, this step is performed by the subtilisin-like serine peptidase ElxP. Bioinformatic, kinetic, and mass spectrometric analysis revealed that ElxP recognizes the stretch of amino acids DLNPQS located near the proteolytic cleavage site of its substrate, ElxA. When the ElxP recognition motif was inserted into the noncognate lanthipeptide precursor NisA, ElxP was able to proteolytically remove the leader peptide from NisA. Proteolytic removal of the leader peptide by ElxP during the biosynthesis of epilancin 15X exposes an N-terminal dehydroalanine on the core peptide of ElxA that hydrolyzes to a pyruvyl group. The short-chain dehydrogenase ElxO reduces the pyruvyl group to a lactyl moiety in the final step of epilancin 15X maturation. Using synthetic peptides, we also investigated the substrate specificity of ElxO and determined the 1.85 A resolution X-ray crystal structure of the enzyme.

-	~~The entry 4qec is ON HOLD~~	+	Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO.,Ortega MA, Velasquez JE, Garg N, Zhang Q, Joyce RE, Nair SK, van der Donk WA ACS Chem Biol. 2014 Jun 6. PMID:24866416<ref>PMID:24866416</ref>

-	~~Authors~~: Garg, N., Nair, S.K.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~ElxO with NADP Bound~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Garg, N.]]
		+	[[Category: Nair, S K.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA at 08:30, 28 May 2014

OCA — Wed, 28 May 2014 08:30:46 GMT

←Older revision		Revision as of 08:30, 28 May 2014
Line 5:		Line 5:
	Authors: Garg, N., Nair, S.K.		Authors: Garg, N., Nair, S.K.

-	Description: ElxO with ~~NADPH~~ Bound	+	Description: ElxO with NADP Bound

OCA: Protected "4qec" [edit=sysop:move=sysop]

OCA — Wed, 21 May 2014 08:20:26 GMT

Protected "4qec" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 21 May 2014

OCA: New page: '''Unreleased structure''' The entry 4qec is ON HOLD Authors: Garg, N., Nair, S.K. Description: ElxO with NADPH Bound

OCA — Wed, 21 May 2014 08:20:24 GMT

New page: '''Unreleased structure''' The entry 4qec is ON HOLD Authors: Garg, N., Nair, S.K. Description: ElxO with NADPH Bound

New page

'''Unreleased structure'''

The entry 4qec is ON HOLD

Authors: Garg, N., Nair, S.K.

Description: ElxO with NADPH Bound