4qei - Revision history

OCA at 15:05, 8 November 2023

OCA — Wed, 08 Nov 2023 15:05:04 GMT

←Older revision		Revision as of 15:05, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.875Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [https://pdbe.org/4qei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [https://www.ebi.ac.uk/pdbsum/4qei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qei ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [https://pdbe.org/4qei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [https://www.ebi.ac.uk/pdbsum/4qei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qei ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:25, 15 February 2023

OCA — Wed, 15 Feb 2023 11:25:59 GMT

←Older revision		Revision as of 11:25, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4qei' size='340' side='right'caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4qei' size='340' side='right'caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QEI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QEI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [https://pdbe.org/4qei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [https://www.ebi.ac.uk/pdbsum/4qei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qei ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [~~http~~://pdbe.org/4qei PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qei PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qei ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SYG_HUMAN SYG_HUMAN~~]~~] Defects in GARS are the cause of~~ Charcot-Marie-Tooth disease type 2D (CMT2D) [MIM:[http://omim.org/entry/601472 601472]]. CMT2D is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2D is characterized by a more severe phenotype in the upper extremities (severe weakness and atrophy, absence of tendon reflexes) than in the lower limbs. CMT2D inheritance is autosomal dominant.<ref>PMID:12690580</ref> Defects in GARS are a cause of distal hereditary motor neuronopathy type 5A (HMN5A) [MIM:[http://omim.org/entry/600794 600794]]; ~~also known as distal~~ hereditary motor neuropathy type ~~V (DSMAV)~~. ~~A disorder characterized~~ by ~~distal muscular atrophy mainly~~ affecting the ~~upper extremities,~~ in ~~contrast to other distal motor neuronopathies~~. ~~These constitute a heterogeneous group of neuromuscular diseases~~ caused by ~~selective degeneration of motor neurons in~~ the ~~anterior horn of the spinal cord, without sensory deficit~~ in ~~the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss~~. The disease ~~starts with weakness and wasting of distal muscles of~~ the ~~anterior tibial and peroneal compartments of the legs~~. ~~Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.<ref>PMID:12690580</ref>~~	+	[https://www.uniprot.org/uniprot/GARS_HUMAN GARS_HUMAN] Autosomal dominant Charcot-Marie-Tooth disease type 2D;Distal hereditary motor neuropathy type 5. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SYG_HUMAN SYG_HUMAN]~~] Catalyzes the ~~attachment~~ of glycine to tRNA(Gly). ~~Is also able produce~~ diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.<ref>PMID:19710017</ref>	+	[https://www.uniprot.org/uniprot/GARS_HUMAN GARS_HUMAN] Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017).<ref>PMID:17544401</ref> <ref>PMID:19710017</ref> <ref>PMID:24898252</ref> <ref>PMID:28675565</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycine--tRNA ligase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Deng, X]]	+	[[Category: Deng X]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	[[Category: Qin, X]]	+	[[Category: Qin X]]
-	[[Category: Xie, W]]	+	[[Category: Xie W]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Glycyl-trna synthetase]]~~	+
-	~~[[Category: Glycylation]]~~	+
-	~~[[Category: Ligase-rna complex]]~~	+
-	~~[[Category: Trna ligase~~]]	+

OCA at 08:43, 24 April 2019

OCA — Wed, 24 Apr 2019 08:43:23 GMT

←Older revision		Revision as of 08:43, 24 April 2019
Line 1:		Line 1:

	==Two distinct conformational states of GlyRS captured in crystal lattice==		==Two distinct conformational states of GlyRS captured in crystal lattice==
-	<StructureSection load='4qei' size='340' side='right' caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>	+	<StructureSection load='4qei' size='340' side='right'caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [http://pdbe.org/4qei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [http://www.ebi.ac.uk/pdbsum/4qei PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [http://pdbe.org/4qei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [http://www.ebi.ac.uk/pdbsum/4qei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qei ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 4qei" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qei" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Glycine--tRNA ligase]]		[[Category: Glycine--tRNA ligase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Deng, X]]		[[Category: Deng, X]]
	[[Category: Li, Q]]		[[Category: Li, Q]]

OCA at 17:51, 10 May 2016

OCA — Tue, 10 May 2016 17:51:23 GMT

←Older revision		Revision as of 17:51, 10 May 2016
Line 1:		Line 1:
		+
	==Two distinct conformational states of GlyRS captured in crystal lattice==		==Two distinct conformational states of GlyRS captured in crystal lattice==
	<StructureSection load='4qei' size='340' side='right' caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4qei' size='340' side='right' caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [http://www.ebi.ac.uk/pdbsum/4qei PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [http://pdbe.org/4qei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [http://www.ebi.ac.uk/pdbsum/4qei PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SYG_HUMAN SYG_HUMAN]] Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.<ref>PMID:19710017</ref>		[[http://www.uniprot.org/uniprot/SYG_HUMAN SYG_HUMAN]] Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.<ref>PMID:19710017</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycyl-tRNA synthetase (GlyRS) is the enzyme that covalently links glycine to cognate tRNA for translation. It is of great research interest because of its nonconserved quaternary structures, unique species-specific aminoacylation properties, and noncanonical functions in neurological diseases, but none of these is fully understood. We report two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism. We discover that insertion 3 differs considerably in conformation in catalysis and that it acts like a "switch" and fully opens to allow tRNA to bind in a cross-subunit fashion. The flexibility of the protein is supported by molecular dynamics simulation, as well as enzymatic activity assays. The biophysical and biochemical studies suggest that human GlyRS may utilize its flexibility for both the traditional function (regulate tRNA binding) and alternative functions (roles in diseases).
		+
		+	Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis.,Deng X, Qin X, Chen L, Jia Q, Zhang Y, Zhang Z, Lei D, Ren G, Zhou Z, Wang Z, Li Q, Xie W J Biol Chem. 2016 Mar 11;291(11):5740-52. doi: 10.1074/jbc.M115.679126. Epub 2016, Jan 21. PMID:26797133<ref>PMID:26797133</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4qei" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:17, 20 May 2015

OCA — Wed, 20 May 2015 12:17:05 GMT

←Older revision		Revision as of 12:17, 20 May 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Two distinct conformational states of GlyRS captured in crystal lattice==
-		+	<StructureSection load='4qei' size='340' side='right' caption='[[4qei]], [[Resolution\|resolution]] 2.88Å' scene=''>
-	~~The entry~~ 4qei is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qei]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QEI FirstGlance]. <br>
-	~~Authors~~: ~~Xie~~, W., ~~Qin~~, X., ~~Deng~~, X., ~~Zhang, Q~~., Li, Q.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
-	~~Description: Two distinct conformational states~~ of ~~GlyRS captured~~ in ~~crystal lattice~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine--tRNA_ligase Glycine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qei RCSB], [http://www.ebi.ac.uk/pdbsum/4qei PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Xie, W~~]]	+	</table>
-	[[Category: ~~Qin, X~~]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SYG_HUMAN SYG_HUMAN]] Defects in GARS are the cause of Charcot-Marie-Tooth disease type 2D (CMT2D) [MIM:[http://omim.org/entry/601472 601472]]. CMT2D is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2D is characterized by a more severe phenotype in the upper extremities (severe weakness and atrophy, absence of tendon reflexes) than in the lower limbs. CMT2D inheritance is autosomal dominant.<ref>PMID:12690580</ref> Defects in GARS are a cause of distal hereditary motor neuronopathy type 5A (HMN5A) [MIM:[http://omim.org/entry/600794 600794]]; also known as distal hereditary motor neuropathy type V (DSMAV). A disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.<ref>PMID:12690580</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYG_HUMAN SYG_HUMAN]] Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.<ref>PMID:19710017</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glycine--tRNA ligase]]
	[[Category: Deng, X]]		[[Category: Deng, X]]
	[[Category: Li, Q]]		[[Category: Li, Q]]
		+	[[Category: Qin, X]]
		+	[[Category: Xie, W]]
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Glycyl-trna synthetase]]
		+	[[Category: Glycylation]]
		+	[[Category: Ligase-rna complex]]
		+	[[Category: Trna ligase]]

OCA at 15:41, 24 December 2014

OCA — Wed, 24 Dec 2014 15:41:07 GMT

←Older revision		Revision as of 15:41, 24 December 2014
Line 6:		Line 6:

	Description: Two distinct conformational states of GlyRS captured in crystal lattice		Description: Two distinct conformational states of GlyRS captured in crystal lattice
		+	[[Category: Unreleased Structures]]
		+	[[Category: Xie, W]]
		+	[[Category: Qin, X]]
		+	[[Category: Deng, X]]
		+	[[Category: Li, Q]]
		+	[[Category: Zhang, Q]]

OCA at 08:03, 11 June 2014

OCA — Wed, 11 Jun 2014 08:03:59 GMT

←Older revision		Revision as of 08:03, 11 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qei is ON HOLD	+	The entry 4qei is ON HOLD until Paper Publication

	Authors: Xie, W., Qin, X., Deng, X., Zhang, Q., Li, Q.		Authors: Xie, W., Qin, X., Deng, X., Zhang, Q., Li, Q.

	Description: Two distinct conformational states of GlyRS captured in crystal lattice		Description: Two distinct conformational states of GlyRS captured in crystal lattice

OCA at 04:57, 4 June 2014

OCA — Wed, 04 Jun 2014 04:57:56 GMT

←Older revision		Revision as of 04:57, 4 June 2014
Line 3:		Line 3:
	The entry 4qei is ON HOLD		The entry 4qei is ON HOLD

-	Authors: Xie, W, Qin, X, Deng, X, Zhang, Q, Li, Q	+	Authors: Xie, W., Qin, X., Deng, X., Zhang, Q., Li, Q.

-	Description: ~~two~~ distinct conformational states of GlyRS captured in crystal lattice	+	Description: Two distinct conformational states of GlyRS captured in crystal lattice

OCA: Protected "4qei" [edit=sysop:move=sysop]

OCA — Wed, 28 May 2014 08:31:01 GMT

Protected "4qei" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:31, 28 May 2014

OCA: New page: '''Unreleased structure''' The entry 4qei is ON HOLD Authors: Xie, W, Qin, X, Deng, X, Zhang, Q, Li, Q Description: two distinct conformational states of GlyRS captured in crystal latt...

OCA — Wed, 28 May 2014 08:30:59 GMT

New page: '''Unreleased structure''' The entry 4qei is ON HOLD Authors: Xie, W, Qin, X, Deng, X, Zhang, Q, Li, Q Description: two distinct conformational states of GlyRS captured in crystal latt...

New page

'''Unreleased structure'''

The entry 4qei is ON HOLD

Authors: Xie, W, Qin, X, Deng, X, Zhang, Q, Li, Q

Description: two distinct conformational states of GlyRS captured in crystal lattice