4qhl - Revision history

OCA at 17:32, 20 September 2023

OCA — Wed, 20 Sep 2023 17:32:20 GMT

←Older revision		Revision as of 17:32, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [https://pdbe.org/4qhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [https://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.153Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [https://pdbe.org/4qhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [https://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:30, 15 February 2023

OCA — Wed, 15 Feb 2023 11:30:17 GMT

←Older revision		Revision as of 11:30, 15 February 2023
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	<StructureSection load='4qhl' size='340' side='right'caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='4qhl' size='340' side='right'caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [https://pdbe.org/4qhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [https://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [~~http~~://pdbe.org/4qhl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6GMX6_HUMAN Q6GMX6_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fera, D]]	+	[[Category: Fera D]]
-	[[Category: Harrison~~, S C]]~~	+	[[Category: Harrison SC]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab fragment]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 08:12, 19 February 2020

OCA — Wed, 19 Feb 2020 08:12:26 GMT

←Older revision		Revision as of 08:12, 19 February 2020
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	==I3.2 (unbound) from CH103 Lineage==		==I3.2 (unbound) from CH103 Lineage==
-	<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>	+	<StructureSection load='4qhl' size='340' side='right'caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fera, D]]		[[Category: Fera, D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 08:53, 22 November 2017

OCA — Wed, 22 Nov 2017 08:53:42 GMT

←Older revision		Revision as of 08:53, 22 November 2017
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	<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://pdbe.org/4qhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://pdbe.org/4qhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Fera, D]]		[[Category: Fera, D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 16:28, 11 August 2016

OCA — Thu, 11 Aug 2016 16:28:15 GMT

←Older revision		Revision as of 16:28, 11 August 2016
Line 1:		Line 1:
		+
	==I3.2 (unbound) from CH103 Lineage==		==I3.2 (unbound) from CH103 Lineage==
	<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://pdbe.org/4qhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qhl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:57, 5 January 2015

OCA — Mon, 05 Jan 2015 12:57:27 GMT

←Older revision		Revision as of 12:57, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fera, D.]]	+	[[Category: Fera, D]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Fab fragment]]		[[Category: Fab fragment]]
	[[Category: Hiv-1]]		[[Category: Hiv-1]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:15, 16 July 2014

OCA — Wed, 16 Jul 2014 09:15:46 GMT

←Older revision		Revision as of 09:15, 16 July 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rapidly evolving pathogens, such as human immunodeficiency and influenza viruses, escape immune defenses provided by most vaccine-induced antibodies. Proposed strategies to elicit broadly neutralizing antibodies require a deeper understanding of antibody affinity maturation and evolution of the immune response to vaccination or infection. In HIV-infected individuals, viruses and B cells evolve together, creating a virus-antibody "arms race." Analysis of samples from an individual designated CH505 has illustrated the interplay between an antibody lineage, CH103, and autologous viruses at various time points. The CH103 antibodies, relatively broad in their neutralization spectrum, interact with the CD4 binding site of gp120, with a contact dominated by CDRH3. We show by analyzing structures of progenitor and intermediate antibodies and by correlating them with measurements of binding to various gp120s that there was a shift in the relative orientation of the light- and heavy-chain variable domains during evolution of the CH103 lineage. We further show that mutations leading to this conformational shift probably occurred in response to insertions in variable loop 5 (V5) of the HIV envelope. The shift displaced the tips of the light chain away from contact with V5, making room for the inserted residues, which had allowed escape from neutralization by the progenitor antibody. These results, which document the selective mechanism underlying this example of a virus-antibody arms race, illustrate the functional significance of affinity maturation by mutation outside the complementarity determining region surface of the antibody molecule.
		+
		+	Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.,Fera D, Schmidt AG, Haynes BF, Gao F, Liao HX, Kepler TB, Harrison SC Proc Natl Acad Sci U S A. 2014 Jun 30. pii: 201409954. PMID:24982157<ref>PMID:24982157</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:59, 11 June 2014

OCA — Wed, 11 Jun 2014 08:59:46 GMT

←Older revision		Revision as of 08:59, 11 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==I3.2 (unbound) from CH103 Lineage==
-		+	<StructureSection load='4qhl' size='340' side='right' caption='[[4qhl]], [[Resolution\|resolution]] 3.15Å' scene=''>
-	~~The entry~~ 4qhl is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qhl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHL FirstGlance]. <br>
-	~~Authors~~: Fera, D., Harrison, S.C.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qhk\|4qhk]], [[4qhm\|4qhm]], [[4qhn\|4qhn]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhl RCSB], [http://www.ebi.ac.uk/pdbsum/4qhl PDBsum]</span></td></tr>
-	~~Description~~: ~~I3.2 (unbound) from CH103 Lineage~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fera, D.]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Antibody]]
		+	[[Category: Fab fragment]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]

OCA: Protected "4qhl" [edit=sysop:move=sysop]

OCA — Wed, 04 Jun 2014 04:59:02 GMT

Protected "4qhl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qhl is ON HOLD Authors: Fera, D., Harrison, S.C. Description: I3.2 (unbound) from CH103 Lineage

OCA — Wed, 04 Jun 2014 04:59:01 GMT

New page: '''Unreleased structure''' The entry 4qhl is ON HOLD Authors: Fera, D., Harrison, S.C. Description: I3.2 (unbound) from CH103 Lineage

New page

'''Unreleased structure'''

The entry 4qhl is ON HOLD

Authors: Fera, D., Harrison, S.C.

Description: I3.2 (unbound) from CH103 Lineage