4qjl - Revision history

OCA at 12:46, 1 March 2024

OCA — Fri, 01 Mar 2024 12:46:53 GMT

←Older revision		Revision as of 12:46, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [https://pdbe.org/4qjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [https://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [https://pdbe.org/4qjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [https://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/A0PQD8_MYCUA A0PQD8_MYCUA]		[https://www.uniprot.org/uniprot/A0PQD8_MYCUA A0PQD8_MYCUA]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	4'-Phosphopantetheinyl transferases (PPTase) post-translationally modify carrier proteins with a phosphopantetheine moiety, an essential reaction in all three domains of life. In the bacterial genus Mycobacteria, the Sfp-type PPTase activates pathways necessary for the biosynthesis of cell wall components and small molecule virulence factors. We solved the X-ray crystal structures and biochemically characterized the Sfp-type PPTases from two of the most prevalent Mycobacterial pathogens, PptT of M. tuberculosis and MuPPT of M. ulcerans. Structural analyses reveal significant differences in cofactor binding and active site composition when compared to previously characterized Sfp-type PPTases. Functional analyses including the efficacy of Sfp-type PPTase-specific inhibitors also suggest that the Mycobacterial Sfp-type PPTases can serve as therapeutic targets against Mycobacterial infections.
-
-	Structure, Biochemistry, and Inhibition of Essential 4'-Phosphopantetheinyl Transferases from Two Species of Mycobacteria.,Vickery CR, Kosa NM, Casavant EP, Duan S, Noel JP, Burkart MD ACS Chem Biol. 2014 Jul 9. PMID:24963544<ref>PMID:24963544</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4qjl" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:32, 15 February 2023

OCA — Wed, 15 Feb 2023 11:32:31 GMT

←Older revision		Revision as of 11:32, 15 February 2023
Line 1:		Line 1:

	==Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT==		==Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT==
-	<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4qjl' size='340' side='right'caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycua Mycua~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [https://pdbe.org/4qjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [https://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUL_2141, MuPPT, pptII, YP_906028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [~~http~~://pdbe.org/4qjl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0PQD8_MYCUA A0PQD8_MYCUA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycua~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Burkart, M D~~]]	+	[[Category: Mycobacterium ulcerans Agy99]]
-	[[Category: ~~Noel, J P~~]]	+	[[Category: Burkart MD]]
-	[[Category: ~~Vickery, C R~~]]	+	[[Category: Noel JP]]
-	[[Category: ~~Coa binding]]~~	+	[[Category: Vickery CR]]
-	~~[[Category: Phosphopantetheinyl transferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:54, 22 November 2017

OCA — Wed, 22 Nov 2017 08:54:41 GMT

←Older revision		Revision as of 08:54, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycua Mycua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MUL_2141, MuPPT, pptII, YP_906028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=362242 MYCUA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://pdbe.org/4qjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://pdbe.org/4qjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mycua]]
	[[Category: Burkart, M D]]		[[Category: Burkart, M D]]
	[[Category: Noel, J P]]		[[Category: Noel, J P]]

OCA at 18:22, 11 August 2016

OCA — Thu, 11 Aug 2016 18:22:59 GMT

←Older revision		Revision as of 18:22, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT==		==Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT==
	<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://pdbe.org/4qjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qjl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qjl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:32, 20 January 2015

OCA — Tue, 20 Jan 2015 08:32:02 GMT

←Older revision		Revision as of 08:32, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Burkart, M D.]]	+	[[Category: Burkart, M D]]
-	[[Category: Noel, J P.]]	+	[[Category: Noel, J P]]
-	[[Category: Vickery, C R.]]	+	[[Category: Vickery, C R]]
	[[Category: Coa binding]]		[[Category: Coa binding]]
	[[Category: Phosphopantetheinyl transferase]]		[[Category: Phosphopantetheinyl transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:15, 16 July 2014

OCA — Wed, 16 Jul 2014 10:15:03 GMT

←Older revision		Revision as of 10:15, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT==
		+	<StructureSection load='4qjl' size='340' side='right' caption='[[4qjl]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qjl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qjk\|4qjk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qjl RCSB], [http://www.ebi.ac.uk/pdbsum/4qjl PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	4'-Phosphopantetheinyl transferases (PPTase) post-translationally modify carrier proteins with a phosphopantetheine moiety, an essential reaction in all three domains of life. In the bacterial genus Mycobacteria, the Sfp-type PPTase activates pathways necessary for the biosynthesis of cell wall components and small molecule virulence factors. We solved the X-ray crystal structures and biochemically characterized the Sfp-type PPTases from two of the most prevalent Mycobacterial pathogens, PptT of M. tuberculosis and MuPPT of M. ulcerans. Structural analyses reveal significant differences in cofactor binding and active site composition when compared to previously characterized Sfp-type PPTases. Functional analyses including the efficacy of Sfp-type PPTase-specific inhibitors also suggest that the Mycobacterial Sfp-type PPTases can serve as therapeutic targets against Mycobacterial infections.

-	~~The entry 4qjl is ON HOLD~~	+	Structure, Biochemistry, and Inhibition of Essential 4'-Phosphopantetheinyl Transferases from Two Species of Mycobacteria.,Vickery CR, Kosa NM, Casavant EP, Duan S, Noel JP, Burkart MD ACS Chem Biol. 2014 Jul 9. PMID:24963544<ref>PMID:24963544</ref>

-	~~Authors: Noel~~, J.P., Burkart, M.D., Vickery, C.R.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of M. ulcerans phosphopantetheinyl~~ transferase ~~MuPPT~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Burkart, M D.]]
		+	[[Category: Noel, J P.]]
		+	[[Category: Vickery, C R.]]
		+	[[Category: Coa binding]]
		+	[[Category: Phosphopantetheinyl transferase]]
		+	[[Category: Transferase]]

OCA at 06:37, 18 June 2014

OCA — Wed, 18 Jun 2014 06:37:55 GMT

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	The entry 4qjl is ON HOLD		The entry 4qjl is ON HOLD

-	Authors: Noel, J. P., Burkart, M. D., Vickery, C.R.	+	Authors: Noel, J.P., Burkart, M.D., Vickery, C.R.

	Description: Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT		Description: Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT

OCA: Protected "4qjl" [edit=sysop:move=sysop]

OCA — Wed, 11 Jun 2014 08:08:54 GMT

Protected "4qjl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:08, 11 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qjl is ON HOLD Authors: Noel, J. P., Burkart, M. D., Vickery, C.R. Description: Crystal structure of M. ulcerans phosphopantetheinyl transferase M...

OCA — Wed, 11 Jun 2014 08:08:53 GMT

New page: '''Unreleased structure''' The entry 4qjl is ON HOLD Authors: Noel, J. P., Burkart, M. D., Vickery, C.R. Description: Crystal structure of M. ulcerans phosphopantetheinyl transferase M...

New page

'''Unreleased structure'''

The entry 4qjl is ON HOLD

Authors: Noel, J. P., Burkart, M. D., Vickery, C.R.

Description: Crystal structure of M. ulcerans phosphopantetheinyl transferase MuPPT