4qn6 - Revision history

OCA at 15:08, 8 November 2023

OCA — Wed, 08 Nov 2023 15:08:54 GMT

←Older revision		Revision as of 15:08, 8 November 2023
Line 1:		Line 1:

	==Crystal structure of Neuraminidase N6 complexed with Laninamivir==		==Crystal structure of Neuraminidase N6 complexed with Laninamivir==
-	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]]' scene=''>	+	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/Nanchang/7-010/2000(H3N6)) Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [https://pdbe.org/4qn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.945Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [https://pdbe.org/4qn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2FCL6_9INFA Q2FCL6_9INFA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the exception of N7, and there is no published report of N6, although a structure has been deposited in the Protein Data Bank. Here, we present the N7 and N6 structures at 2.1 A and 1.8 A, respectively. Structural comparison of all NA subtypes shows that both N7 and N6 highly resemble typical group 2 NA structures with some special characteristics, including an additional cavity adjacent to their active sites formed by novel 340-loop conformations. Comparative analysis also revealed new structural insights into the N-glycosylation, calcium binding, and second sialic acid binding site of influenza virus NA. This comprehensive study is critical for understanding the complexity of the most successful influenza drug target and for the structure-based design of novel influenza inhibitors. IMPORTANCE: Influenza viruses impose a great burden on society, by the human-adapted seasonal types as well as by variants that occasionally jump from the avian reservoir to infect humans. The surface glycoprotein neuraminidase (NA) is essential for the propagation of the virus and currently the most successfully drug-targeted molecule. Therefore, the structural and functional analysis of NA is critical for the prevention and control of influenza infections. There are nine subtypes of influenza A virus NA (N1 to N9). In addition, influenza B virus also contains NA, and there are two influenza NA-like molecules, N10 and N11, which were recently identified in bats. Crystal structures for all of these proteins have been solved and reported with the exception of N7 and N6. The structural analysis of influenza virus N7 and N6 presented in this study therefore completes the puzzle and adds to a comprehensive understanding of influenza virus NA.
		+
		+	Structure of influenza virus n7: the last piece of the neuraminidase "jigsaw" puzzle.,Sun X, Li Q, Wu Y, Wang M, Liu Y, Qi J, Vavricka CJ, Gao GF J Virol. 2014 Aug 15;88(16):9197-207. doi: 10.1128/JVI.00805-14. Epub 2014 Jun 4. PMID:24899180<ref>PMID:24899180</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4qn6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:55, 31 August 2022

OCA — Wed, 31 Aug 2022 10:55:45 GMT

←Older revision		Revision as of 10:55, 31 August 2022
Line 1:		Line 1:

	==Crystal structure of Neuraminidase N6 complexed with Laninamivir==		==Crystal structure of Neuraminidase N6 complexed with Laninamivir==
-	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]]~~, [[Resolution\|resolution]] 1.94Å~~' scene=''>	+	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[4qn6]] is a 2 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [https://pdbe.org/4qn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</div></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [https://pdbe.org/4qn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>	+
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the exception of N7, and there is no published report of N6, although a structure has been deposited in the Protein Data Bank. Here, we present the N7 and N6 structures at 2.1 A and 1.8 A, respectively. Structural comparison of all NA subtypes shows that both N7 and N6 highly resemble typical group 2 NA structures with some special characteristics, including an additional cavity adjacent to their active sites formed by novel 340-loop conformations. Comparative analysis also revealed new structural insights into the N-glycosylation, calcium binding, and second sialic acid binding site of influenza virus NA. This comprehensive study is critical for understanding the complexity of the most successful influenza drug target and for the structure-based design of novel influenza inhibitors. IMPORTANCE: Influenza viruses impose a great burden on society, by the human-adapted seasonal types as well as by variants that occasionally jump from the avian reservoir to infect humans. The surface glycoprotein neuraminidase (NA) is essential for the propagation of the virus and currently the most successfully drug-targeted molecule. Therefore, the structural and functional analysis of NA is critical for the prevention and control of influenza infections. There are nine subtypes of influenza A virus NA (N1 to N9). In addition, influenza B virus also contains NA, and there are two influenza NA-like molecules, N10 and N11, which were recently identified in bats. Crystal structures for all of these proteins have been solved and reported with the exception of N7 and N6. The structural analysis of influenza virus N7 and N6 presented in this study therefore completes the puzzle and adds to a comprehensive understanding of influenza virus NA.
-
-	Structure of influenza virus n7: the last piece of the neuraminidase "jigsaw" puzzle.,Sun X, Li Q, Wu Y, Wang M, Liu Y, Qi J, Vavricka CJ, Gao GF J Virol. 2014 Aug 15;88(16):9197-207. doi: 10.1128/JVI.00805-14. Epub 2014 Jun 4. PMID:24899180<ref>PMID:24899180</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4qn6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Sun, X]]	+	[[Category: Sun X]]
-	[[Category: Vavricka~~, C J~~]]	+	[[Category: Vavricka CJ]]
-	[[Category: Wu, Y]]	+	[[Category: Wu Y]]
-	~~[[Category: 6-bladed beta-propeller]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:07, 25 August 2022

OCA — Thu, 25 Aug 2022 05:07:19 GMT

←Older revision		Revision as of 05:07, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/chicken/nanchang/7-010/2000(h3n6)) Influenza a virus (a/chicken/nanchang/7-010/2000(h3n6))]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td>~~</tr>~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=215864 Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [https://pdbe.org/4qn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [~~http~~://pdbe.org/4qn6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 19:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:23, 24 April 2019

OCA — Wed, 24 Apr 2019 09:23:33 GMT

←Older revision		Revision as of 09:23, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of Neuraminidase N6 complexed with Laninamivir==		==Crystal structure of Neuraminidase N6 complexed with Laninamivir==
-	<StructureSection load='4qn6' size='340' side='right' caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='4qn6' size='340' side='right'caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/chicken/nanchang/7-010/2000(h3n6)) Influenza a virus (a/chicken/nanchang/7-010/2000(h3n6))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=215864 Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://pdbe.org/4qn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://pdbe.org/4qn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4qn6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qn6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]
	[[Category: Li, Q]]		[[Category: Li, Q]]

OCA at 10:26, 11 August 2016

OCA — Thu, 11 Aug 2016 10:26:12 GMT

←Older revision		Revision as of 10:26, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Neuraminidase N6 complexed with Laninamivir==		==Crystal structure of Neuraminidase N6 complexed with Laninamivir==
	<StructureSection load='4qn6' size='340' side='right' caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4qn6' size='340' side='right' caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://pdbe.org/4qn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qn6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:48, 5 January 2015

OCA — Mon, 05 Jan 2015 14:48:10 GMT

←Older revision		Revision as of 14:48, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Qi, J.]]	+	[[Category: Qi, J]]
-	[[Category: Sun, X.]]	+	[[Category: Sun, X]]
-	[[Category: Vavricka, C J.]]	+	[[Category: Vavricka, C J]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: 6-bladed beta-propeller]]		[[Category: 6-bladed beta-propeller]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:42, 30 July 2014

OCA — Wed, 30 Jul 2014 07:42:12 GMT

←Older revision		Revision as of 07:42, 30 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Neuraminidase N6 complexed with Laninamivir==
		+	<StructureSection load='4qn6' size='340' side='right' caption='[[4qn6]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LNV:5-(ACETYLAMINO)-2,6-ANHYDRO-4-CARBAMIMIDAMIDO-3,4,5-TRIDEOXY-7-O-METHYL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>LNV</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qn3\|4qn3]], [[4qn4\|4qn4]], [[4qn5\|4qn5]], [[4qn7\|4qn7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the exception of N7, and there is no published report of N6, although a structure has been deposited in the Protein Data Bank. Here, we present the N7 and N6 structures at 2.1 A and 1.8 A, respectively. Structural comparison of all NA subtypes shows that both N7 and N6 highly resemble typical group 2 NA structures with some special characteristics, including an additional cavity adjacent to their active sites formed by novel 340-loop conformations. Comparative analysis also revealed new structural insights into the N-glycosylation, calcium binding, and second sialic acid binding site of influenza virus NA. This comprehensive study is critical for understanding the complexity of the most successful influenza drug target and for the structure-based design of novel influenza inhibitors. IMPORTANCE: Influenza viruses impose a great burden on society, by the human-adapted seasonal types as well as by variants that occasionally jump from the avian reservoir to infect humans. The surface glycoprotein neuraminidase (NA) is essential for the propagation of the virus and currently the most successfully drug-targeted molecule. Therefore, the structural and functional analysis of NA is critical for the prevention and control of influenza infections. There are nine subtypes of influenza A virus NA (N1 to N9). In addition, influenza B virus also contains NA, and there are two influenza NA-like molecules, N10 and N11, which were recently identified in bats. Crystal structures for all of these proteins have been solved and reported with the exception of N7 and N6. The structural analysis of influenza virus N7 and N6 presented in this study therefore completes the puzzle and adds to a comprehensive understanding of influenza virus NA.

-	~~The entry 4qn6 is ON HOLD~~	+	Structure of influenza virus n7: the last piece of the neuraminidase "jigsaw" puzzle.,Sun X, Li Q, Wu Y, Wang M, Liu Y, Qi J, Vavricka CJ, Gao GF J Virol. 2014 Aug 15;88(16):9197-207. doi: 10.1128/JVI.00805-14. Epub 2014 Jun 4. PMID:24899180<ref>PMID:24899180</ref>

-	~~Authors: Sun~~, X., Li, Q.~~, Wu, Y.,~~ Liu, Y., Qi, J., Vavricka, C.J., ~~Gao, G.F~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Neuraminidase N6 complexed with Laninamivir~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gao, G F.]]
		+	[[Category: Li, Q.]]
		+	[[Category: Liu, Y.]]
		+	[[Category: Qi, J.]]
		+	[[Category: Sun, X.]]
		+	[[Category: Vavricka, C J.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: 6-bladed beta-propeller]]
		+	[[Category: Calcium binding]]
		+	[[Category: Glycosylation]]
		+	[[Category: Hydrolase]]

OCA: Protected "4qn6" [edit=sysop:move=sysop]

OCA — Wed, 25 Jun 2014 05:58:19 GMT

Protected "4qn6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qn6 is ON HOLD Authors: Sun, X., Li, Q., Wu, Y., Liu, Y., Qi, J., Vavricka, C.J., Gao, G.F. Description: Crystal structure of Neuraminidase N6 com...

OCA — Wed, 25 Jun 2014 05:58:18 GMT

New page: '''Unreleased structure''' The entry 4qn6 is ON HOLD Authors: Sun, X., Li, Q., Wu, Y., Liu, Y., Qi, J., Vavricka, C.J., Gao, G.F. Description: Crystal structure of Neuraminidase N6 com...

New page

'''Unreleased structure'''

The entry 4qn6 is ON HOLD

Authors: Sun, X., Li, Q., Wu, Y., Liu, Y., Qi, J., Vavricka, C.J., Gao, G.F.

Description: Crystal structure of Neuraminidase N6 complexed with Laninamivir