4qo0 - Revision history

OCA at 17:34, 20 September 2023

OCA — Wed, 20 Sep 2023 17:34:06 GMT

←Older revision		Revision as of 17:34, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [https://pdbe.org/4qo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [https://pdbe.org/4qo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:43, 22 February 2023

OCA — Wed, 22 Feb 2023 13:43:25 GMT

←Older revision		Revision as of 13:43, 22 February 2023
Line 3:		Line 3:
	<StructureSection load='4qo0' size='340' side='right'caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4qo0' size='340' side='right'caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr.~~_mc4100~~ Escherichia coli str. k-12 substr. ~~mc4100~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [https://pdbe.org/4qo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [https://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</~~b></td><td class="sblockDat"~~>~~glpG~~, ~~BN896_3117 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1403831 Escherichia coli str. K-12 substr. MC4100])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [~~http~~://pdbe.org/4qo0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/U6NA71_ECOLI U6NA71_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity).[HAMAP-Rule:MF_01594]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Escherichia coli str. k-12 substr. ~~mc4100~~]]	+	[[Category: Escherichia coli str. K-12 substr. MC4100]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Rhomboid protease]]~~	+	[[Category: Strisovsky K]]
-	[[Category: Strisovsky, K]]	+	[[Category: Zoll S]]
-	[[Category: Zoll, S]]	+
-	~~[[Category: Alpha-helical]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Rhomboid intramembrane protease~~]]	+

OCA at 08:59, 24 April 2019

OCA — Wed, 24 Apr 2019 08:59:55 GMT

←Older revision		Revision as of 08:59, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-FATA-cmk==		==Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-FATA-cmk==
-	<StructureSection load='4qo0' size='340' side='right' caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4qo0' size='340' side='right'caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mc4100 Escherichia coli str. k-12 substr. mc4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glpG, BN896_3117 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1403831 Escherichia coli str. K-12 substr. MC4100])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://pdbe.org/4qo0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://pdbe.org/4qo0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>
Line 28:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli str. k-12 substr. mc4100]]
		+	[[Category: Large Structures]]
	[[Category: Rhomboid protease]]		[[Category: Rhomboid protease]]
	[[Category: Strisovsky, K]]		[[Category: Strisovsky, K]]

OCA at 07:05, 5 August 2016

OCA — Fri, 05 Aug 2016 07:05:02 GMT

←Older revision		Revision as of 07:05, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-FATA-cmk==		==Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-FATA-cmk==
	<StructureSection load='4qo0' size='340' side='right' caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4qo0' size='340' side='right' caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://pdbe.org/4qo0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qo0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qo0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rhomboid protease\|Rhomboid protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:43, 25 December 2014

OCA — Thu, 25 Dec 2014 16:43:55 GMT

←Older revision		Revision as of 16:43, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U6NA71_ECOLI U6NA71_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity).[HAMAP-Rule:MF_01594]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Rhomboid protease]]		[[Category: Rhomboid protease]]
-	[[Category: Strisovsky, K.]]	+	[[Category: Strisovsky, K]]
-	[[Category: Zoll, S.]]	+	[[Category: Zoll, S]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Rhomboid intramembrane protease]]		[[Category: Rhomboid intramembrane protease]]

OCA at 09:07, 29 October 2014

OCA — Wed, 29 Oct 2014 09:07:40 GMT

←Older revision		Revision as of 09:07, 29 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:31, 24 September 2014

OCA — Wed, 24 Sep 2014 10:31:51 GMT

←Older revision		Revision as of 10:31, 24 September 2014
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-	'''~~Unreleased~~ structure'''	+	==Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-FATA-cmk==
		+	<StructureSection load='4qo0' size='340' side='right' caption='[[4qo0]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qo0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QO0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qnz\|4qnz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qo0 RCSB], [http://www.ebi.ac.uk/pdbsum/4qo0 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethylketone (CMK) inhibitors and analysed their interactions with Escherichia coli rhomboid GlpG enzymologically and structurally. We show that peptidyl-CMKs derived from the natural rhomboid substrate TatA from bacterium Providencia stuartii bind GlpG in a substrate-like manner, and their co-crystal structures with GlpG reveal the S1 to S4 subsites of the protease. The S1 subsite is prominent and merges into the 'water retention site', suggesting intimate interplay between substrate binding, specificity and catalysis. Unexpectedly, the S4 subsite is plastically formed by residues of the L1 loop, an important but hitherto enigmatic feature of the rhomboid fold. We propose that the homologous region of members of the wider rhomboid-like protein superfamily may have similar substrate or client-protein binding function. Finally, using molecular dynamics, we generate a model of the Michaelis complex of the substrate bound in the active site of GlpG.

-	~~The entry 4qo0 is ON HOLD~~	+	Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.,Zoll S, Stanchev S, Began J, Skerle J, Lepsik M, Peclinovska L, Majer P, Strisovsky K EMBO J. 2014 Sep 12. pii: e201489367. PMID:25216680<ref>PMID:25216680</ref>

-	~~Authors: Zoll~~, S., Strisovsky, K.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structural analysis of protease~~ complex 2	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Rhomboid protease]]
		+	[[Category: Strisovsky, K.]]
		+	[[Category: Zoll, S.]]
		+	[[Category: Alpha-helical]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Rhomboid intramembrane protease]]

OCA: Protected "4qo0" [edit=sysop:move=sysop]

OCA — Wed, 25 Jun 2014 05:58:47 GMT

Protected "4qo0" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qo0 is ON HOLD Authors: Zoll, S., Strisovsky, K. Description: Structural analysis of protease complex 2

OCA — Wed, 25 Jun 2014 05:58:47 GMT

New page: '''Unreleased structure''' The entry 4qo0 is ON HOLD Authors: Zoll, S., Strisovsky, K. Description: Structural analysis of protease complex 2

New page

'''Unreleased structure'''

The entry 4qo0 is ON HOLD

Authors: Zoll, S., Strisovsky, K.

Description: Structural analysis of protease complex 2