4qqn - Revision history

OCA at 17:35, 20 September 2023

OCA — Wed, 20 Sep 2023 17:35:45 GMT

←Older revision		Revision as of 17:35, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.08Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [https://pdbe.org/4qqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [https://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [https://pdbe.org/4qqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [https://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:47, 22 February 2023

OCA — Wed, 22 Feb 2023 13:47:17 GMT

←Older revision		Revision as of 13:47, 22 February 2023
Line 1:		Line 1:

	==Protein arginine methyltransferase 3 in complex with compound MTV044246==		==Protein arginine methyltransferase 3 in complex with compound MTV044246==
-	<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='4qqn' size='340' side='right'caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRMT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [https://pdbe.org/4qqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [https://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [~~http~~://pdbe.org/4qqn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ANM3_HUMAN ANM3_HUMAN] Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: Bountra, C]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Brown~~, P J~~]]	+	[[Category: Bountra C]]
-	[[Category: Chen, Z]]	+	[[Category: Brown PJ]]
-	[[Category: Dai, M]]	+	[[Category: Chen Z]]
-	[[Category: Dobrovetsky, E]]	+	[[Category: Dai M]]
-	[[Category: Dong, A]]	+	[[Category: Dobrovetsky E]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Dong A]]
-	[[Category: He, H]]	+	[[Category: Edwards AM]]
-	[[Category: Landon, M]]	+	[[Category: He H]]
-	[[Category: Lin, Y]]	+	[[Category: Landon M]]
-	[[Category: Luo, X]]	+	[[Category: Lin Y]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Luo X]]
-	[[Category: Schapira, M]]	+	[[Category: Schapira M]]
-	[[Category: Smil, D]]	+	[[Category: Smil D]]
-	[[Category: Tempel, W]]	+	[[Category: Tempel W]]
-	[[Category: Vedadi, M]]	+	[[Category: Vedadi M]]
-	[[Category: Yu, Z]]	+	[[Category: Yu Z]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	[[Category: Zhao, K]]	+	[[Category: Zhao K]]
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Prmt3]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:43, 16 May 2018

OCA — Wed, 16 May 2018 05:43:12 GMT

←Older revision		Revision as of 05:43, 16 May 2018
Line 3:		Line 3:
	<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRMT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [http://pdbe.org/4qqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [http://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [http://pdbe.org/4qqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [http://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric inhibitor of PRMT3, compound 4. Here, we report comprehensive structure-activity relationship studies that target the allosteric binding site of PRMT3. We conducted design, synthesis, and evaluation of novel compounds in biochemical, selectivity, and cellular assays that culminated in the discovery of 4 and other highly potent (IC50 values: approximately 10-36 nM), selective, and cell-active allosteric inhibitors of PRMT3 (compounds 29, 30, 36, and 37). In addition, we generated compounds that are very close analogs of these potent inhibitors but displayed drastically reduced potency as negative controls (compounds 49-51). These inhibitors and negative controls are valuable chemical tools for the biomedical community to further investigate biological functions and disease associations of PRMT3.
		+
		+	Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).,Kaniskan HU, Eram MS, Zhao K, Szewczyk MM, Yang X, Schmidt K, Luo X, Xiao S, Dai M, He F, Zang I, Lin Y, Li F, Dobrovetsky E, Smil D, Min SJ, Lin-Jones J, Schapira M, Atadja P, Li E, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Liu F, Yu Z, Vedadi M, Jin J J Med Chem. 2018 Feb 8;61(3):1204-1217. doi: 10.1021/acs.jmedchem.7b01674. Epub, 2018 Jan 5. PMID:29244490<ref>PMID:29244490</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4qqn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 17:14, 4 January 2017

OCA — Wed, 04 Jan 2017 17:14:41 GMT

←Older revision		Revision as of 17:14, 4 January 2017
Line 1:		Line 1:
		+
	==Protein arginine methyltransferase 3 in complex with compound MTV044246==		==Protein arginine methyltransferase 3 in complex with compound MTV044246==
	<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [http://www.ebi.ac.uk/pdbsum/4qqn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [http://pdbe.org/4qqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [http://www.ebi.ac.uk/pdbsum/4qqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqn ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:47, 22 January 2015

OCA — Thu, 22 Jan 2015 06:47:00 GMT

←Older revision		Revision as of 06:47, 22 January 2015
Line 8:		Line 8:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Brown, P J.]]	+	[[Category: Brown, P J]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Dai, M.]]	+	[[Category: Dai, M]]
-	[[Category: Dobrovetsky, E.]]	+	[[Category: Dobrovetsky, E]]
-	[[Category: Dong, A.]]	+	[[Category: Dong, A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: He, H.]]	+	[[Category: He, H]]
-	[[Category: Landon, M.]]	+	[[Category: Landon, M]]
-	[[Category: Lin, Y.]]	+	[[Category: Lin, Y]]
-	[[Category: Luo, X.]]	+	[[Category: Luo, X]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Schapira, M.]]	+	[[Category: Schapira, M]]
-	[[Category: Smil, D.]]	+	[[Category: Smil, D]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Yu, Z.]]	+	[[Category: Yu, Z]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
-	[[Category: Zhao, K.]]	+	[[Category: Zhao, K]]
	[[Category: Epigenetic]]		[[Category: Epigenetic]]
	[[Category: Prmt3]]		[[Category: Prmt3]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:47, 20 October 2014

OCA — Mon, 20 Oct 2014 08:47:32 GMT

←Older revision		Revision as of 08:47, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Protein arginine methyltransferase 3 in complex with compound MTV044246==
-		+	<StructureSection load='4qqn' size='340' side='right' caption='[[4qqn]], [[Resolution\|resolution]] 2.08Å' scene=''>
-	~~The entry~~ 4qqn is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQN FirstGlance]. <br>
-	~~Authors~~: ~~Dong~~, A., ~~Dobrovetsky~~, E., ~~Tempel~~, W., He, H., ~~Zhao~~, K., ~~Smil, D~~.~~, Landon~~, M., ~~Schapira~~, M., ~~Vedadi~~, M., ~~Bountra~~, C., ~~Arrowsmith~~, C.H., ~~Edwards, A~~.M., ~~Brown~~, ~~P.J~~., Structural ~~Genomics Consortium (SGC)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BQ:1-{2-[1-(AMINOMETHYL)CYCLOHEXYL]ETHYL}-3-ISOQUINOLIN-6-YLUREA'>3BQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqn RCSB], [http://www.ebi.ac.uk/pdbsum/4qqn PDBsum]</span></td></tr>
-	~~Description~~: ~~Protein arginine methyltransferase 3 in complex with compound MTV044246~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Brown, P J.]]
		+	[[Category: Chen, Z.]]
		+	[[Category: Dai, M.]]
		+	[[Category: Dobrovetsky, E.]]
		+	[[Category: Dong, A.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: He, H.]]
		+	[[Category: Landon, M.]]
		+	[[Category: Lin, Y.]]
		+	[[Category: Luo, X.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Schapira, M.]]
		+	[[Category: Smil, D.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Vedadi, M.]]
		+	[[Category: Yu, Z.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Zhao, K.]]
		+	[[Category: Epigenetic]]
		+	[[Category: Prmt3]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transferase]]

OCA at 07:01, 30 July 2014

OCA — Wed, 30 Jul 2014 07:01:33 GMT

←Older revision		Revision as of 07:01, 30 July 2014
Line 3:		Line 3:
	The entry 4qqn is ON HOLD		The entry 4qqn is ON HOLD

-	Authors: ~~DONG~~, A., ~~DOBROVETSKY~~, E., ~~TEMPEL~~, W., HE, H., ~~ZHAO~~,K., ~~SMIL~~, D., ~~LANDON~~,M., ~~SCHAPIRA~~, M., ~~VEDADI~~, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., ~~BROWN~~, P.J., Structural Genomics Consortium (SGC)	+	Authors: Dong, A., Dobrovetsky, E., Tempel, W., He, H., Zhao, K., Smil, D., Landon, M., Schapira, M., Vedadi, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)

	Description: Protein arginine methyltransferase 3 in complex with compound MTV044246		Description: Protein arginine methyltransferase 3 in complex with compound MTV044246

OCA: Protected "4qqn" [edit=sysop:move=sysop]

OCA — Wed, 09 Jul 2014 06:52:43 GMT

Protected "4qqn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 9 July 2014

OCA: New page: '''Unreleased structure''' The entry 4qqn is ON HOLD Authors: DONG, A., DOBROVETSKY, E., TEMPEL, W., HE, H., ZHAO,K., SMIL, D., LANDON,M., SCHAPIRA, M., VEDADI, M., Bountra, C., Arrowsm...

OCA — Wed, 09 Jul 2014 06:52:43 GMT

New page: '''Unreleased structure''' The entry 4qqn is ON HOLD Authors: DONG, A., DOBROVETSKY, E., TEMPEL, W., HE, H., ZHAO,K., SMIL, D., LANDON,M., SCHAPIRA, M., VEDADI, M., Bountra, C., Arrowsm...

New page

'''Unreleased structure'''

The entry 4qqn is ON HOLD

Authors: DONG, A., DOBROVETSKY, E., TEMPEL, W., HE, H., ZHAO,K., SMIL, D., LANDON,M., SCHAPIRA, M., VEDADI, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)

Description: Protein arginine methyltransferase 3 in complex with compound MTV044246