4qqv - Revision history

OCA at 17:35, 20 September 2023

OCA — Wed, 20 Sep 2023 17:35:51 GMT

←Older revision		Revision as of 17:35, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [https://pdbe.org/4qqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [https://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [https://pdbe.org/4qqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [https://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:47, 22 February 2023

OCA — Wed, 22 Feb 2023 13:47:49 GMT

←Older revision		Revision as of 13:47, 22 February 2023
Line 3:		Line 3:
	<StructureSection load='4qqv' size='340' side='right'caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>		<StructureSection load='4qqv' size='340' side='right'caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [https://pdbe.org/4qqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [https://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ai2ca, Csf2rb2, Il3r, Il3rb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [~~http~~://pdbe.org/4qqv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IL3B2_MOUSE IL3B2_MOUSE]] In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.	+	[https://www.uniprot.org/uniprot/IL3B2_MOUSE IL3B2_MOUSE] In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Interleukin receptor\|Interleukin receptor]]	+	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Carr~~, P D~~]]	+	[[Category: Carr PD]]
-	[[Category: Dai, J]]	+	[[Category: Dai J]]
-	[[Category: Ewens~~, C L~~]]	+	[[Category: Ewens CL]]
-	[[Category: Jackson~~, C J~~]]	+	[[Category: Jackson CJ]]
-	[[Category: Murphy~~, J M~~]]	+	[[Category: Murphy JM]]
-	[[Category: Ollis~~, D L~~]]	+	[[Category: Ollis DL]]
-	[[Category: Young~~, I G]]~~	+	[[Category: Young IG]]
-	~~[[Category: Cytokine receptor]]~~	+
-	~~[[Category: Interleukin-3]]~~	+
-	~~[[Category: Intertwined dimer]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:18, 24 April 2019

OCA — Wed, 24 Apr 2019 09:18:42 GMT

←Older revision		Revision as of 09:18, 24 April 2019
Line 1:		Line 1:

	==Extracellular domains of mouse IL-3 beta receptor==		==Extracellular domains of mouse IL-3 beta receptor==
-	<StructureSection load='4qqv' size='340' side='right' caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>	+	<StructureSection load='4qqv' size='340' side='right'caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ai2ca, Csf2rb2, Il3r, Il3rb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://pdbe.org/4qqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://pdbe.org/4qqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Carr, P D]]		[[Category: Carr, P D]]
	[[Category: Dai, J]]		[[Category: Dai, J]]

OCA at 20:43, 4 August 2016

OCA — Thu, 04 Aug 2016 20:43:50 GMT

←Older revision		Revision as of 20:43, 4 August 2016
Line 1:		Line 1:
		+
	==Extracellular domains of mouse IL-3 beta receptor==		==Extracellular domains of mouse IL-3 beta receptor==
	<StructureSection load='4qqv' size='340' side='right' caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>		<StructureSection load='4qqv' size='340' side='right' caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://pdbe.org/4qqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qqv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin receptor\|Interleukin receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:28, 24 December 2014

OCA — Wed, 24 Dec 2014 19:28:41 GMT

←Older revision		Revision as of 19:28, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL3B2_MOUSE IL3B2_MOUSE]] In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carr, P D.]]	+	[[Category: Carr, P D]]
-	[[Category: Dai, J.]]	+	[[Category: Dai, J]]
-	[[Category: Ewens, C L.]]	+	[[Category: Ewens, C L]]
-	[[Category: Jackson, C J.]]	+	[[Category: Jackson, C J]]
-	[[Category: Murphy, J M.]]	+	[[Category: Murphy, J M]]
-	[[Category: Ollis, D L.]]	+	[[Category: Ollis, D L]]
-	[[Category: Young, I G.]]	+	[[Category: Young, I G]]
	[[Category: Cytokine receptor]]		[[Category: Cytokine receptor]]
	[[Category: Interleukin-3]]		[[Category: Interleukin-3]]
	[[Category: Intertwined dimer]]		[[Category: Intertwined dimer]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 08:41, 22 October 2014

OCA — Wed, 22 Oct 2014 08:41:54 GMT

←Older revision		Revision as of 08:41, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:52, 4 September 2014

OCA — Thu, 04 Sep 2014 05:52:35 GMT

←Older revision		Revision as of 05:52, 4 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Extracellular domains of mouse IL-3 beta receptor==
		+	<StructureSection load='4qqv' size='340' side='right' caption='[[4qqv]], [[Resolution\|resolution]] 3.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qqv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gys\|2gys]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqv RCSB], [http://www.ebi.ac.uk/pdbsum/4qqv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin-3 (IL-3) is a cytokine secreted by mast cells and activated T-cells known to be an important regulator of differentiation, survival, proliferation and activation of a range of hematopoietic lineages. The effects of IL-3 on target cells are mediated by a transmembrane receptor system composed of a cytokine-specific alpha-subunit and a beta-subunit, the principal signalling entity. In the mouse, two beta-subunits have co-evolved: a common beta-subunit (betac) shared between IL-3 and the related cytokines, IL-5 and GM-CSF; and an IL-3-specific beta-subunit (betaIL-3). betaIL3 differs from betac in its specificity for IL-3 and its capacity to bind IL-3 directly in the absence of an alpha-subunit and, in the absence of structural information, the basis for these properties has remained enigmatic. Here, we present the crystal structure of the betaIL-3 ectodomain at 3.45 A resolution. This structure provides the first evidence that betaIL-3 adopts an arch-shaped, intertwined homodimer with similar topology to the paralogous betac structure. In contrast to apo-betac, however, the ligand-binding interface of betaIL3 appears to pre-exist in a conformation receptive to IL-3 engagement. Molecular modelling of the IL-3:betaIL3 interface, in conjunction with previous mutational studies, suggests that divergent evolution of both betaIL3 and IL-3 underlies their unique capacity for direct interaction and specificity.

-	~~The entry 4qqv is ON HOLD~~	+	Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin3 binding and receptor activation.,Carr PD, Ewens CL, Dai J, Ollis DL, Murphy JM, Jackson CJ, Young IG Biochem J. 2014 Aug 19. PMID:25137390<ref>PMID:25137390</ref>

-	~~Authors: Jackson~~, C.J.~~, Young, I.G~~.~~, Murphy, J.M.,~~ Carr, P.D., Ewens, C.L., ~~Dai,~~ J., Ollis, D.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Extracellular domains of mouse IL~~-3 ~~beta receptor~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carr, P D.]]
		+	[[Category: Dai, J.]]
		+	[[Category: Ewens, C L.]]
		+	[[Category: Jackson, C J.]]
		+	[[Category: Murphy, J M.]]
		+	[[Category: Ollis, D L.]]
		+	[[Category: Young, I G.]]
		+	[[Category: Cytokine receptor]]
		+	[[Category: Interleukin-3]]
		+	[[Category: Intertwined dimer]]
		+	[[Category: Signaling protein]]

OCA: Protected "4qqv" [edit=sysop:move=sysop]

OCA — Wed, 09 Jul 2014 06:52:52 GMT

Protected "4qqv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:52, 9 July 2014

OCA: New page: '''Unreleased structure''' The entry 4qqv is ON HOLD Authors: Jackson, C.J., Young, I.G., Murphy, J.M., Carr, P.D., Ewens, C.L., Dai, J., Ollis, D.L. Description: Extracellular domains...

OCA — Wed, 09 Jul 2014 06:52:51 GMT

New page: '''Unreleased structure''' The entry 4qqv is ON HOLD Authors: Jackson, C.J., Young, I.G., Murphy, J.M., Carr, P.D., Ewens, C.L., Dai, J., Ollis, D.L. Description: Extracellular domains...

New page

'''Unreleased structure'''

The entry 4qqv is ON HOLD

Authors: Jackson, C.J., Young, I.G., Murphy, J.M., Carr, P.D., Ewens, C.L., Dai, J., Ollis, D.L.

Description: Extracellular domains of mouse IL-3 beta receptor