4qr7 - Revision history

OCA at 17:32, 8 November 2023

OCA — Wed, 08 Nov 2023 17:32:15 GMT

←Older revision		Revision as of 17:32, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='4qr7' size='340' side='right'caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4qr7' size='340' side='right'caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.303Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4qra\|4qra]], [[4qrb\|4qrb]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ldtB, Rv2518c, RVBD_2518c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [https://pdbe.org/4qr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [https://pdbe.org/4qr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>	+	[https://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Gokulan, K]]	+	[[Category: Gokulan K]]
-	[[Category: Varughese~~, K I]]~~	+	[[Category: Varughese KI]]
-	~~[[Category: Beta-lactamase]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: D-d-transpeptidase]]~~	+
-	~~[[Category: Enzyme function initiative]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Imipenem]]~~	+
-	~~[[Category: L-d-transpeptidase]]~~	+
-	~~[[Category: Meropenem]]~~	+
-	~~[[Category: Peptidoglycan]]~~	+
-	~~[[Category: Single anomalous diffraction~~]]	+

OCA at 07:05, 2 February 2022

OCA — Wed, 02 Feb 2022 07:05:51 GMT

←Older revision		Revision as of 07:05, 2 February 2022
Line 1:		Line 1:

	==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==		==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==
-	<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4qr7' size='340' side='right'caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4qra\|4qra]], [[4qrb\|4qrb]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ldtB, Rv2518c, RVBD_2518c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ldtB, Rv2518c, RVBD_2518c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [~~http~~://pdbe.org/4qr7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [https://pdbe.org/4qr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>	+	[[https://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]

OCA at 08:57, 22 November 2017

OCA — Wed, 22 Nov 2017 08:57:04 GMT

←Older revision		Revision as of 08:57, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ldtB, Rv2518c, RVBD_2518c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [http://pdbe.org/4qr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [http://pdbe.org/4qr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>
	</table>		</table>
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Myctu]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]
	[[Category: Varughese, K I]]		[[Category: Varughese, K I]]

OCA at 05:17, 9 September 2016

OCA — Fri, 09 Sep 2016 05:17:29 GMT

←Older revision		Revision as of 05:17, 9 September 2016
Line 1:		Line 1:
		+
	==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==		==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==
	<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [http://pdbe.org/4qr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Structural genomic]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]
	[[Category: Varughese, K I]]		[[Category: Varughese, K I]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Structural genomic]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: D-d-transpeptidase]]		[[Category: D-d-transpeptidase]]

OCA at 14:46, 29 July 2015

OCA — Wed, 29 Jul 2015 14:46:25 GMT

←Older revision		Revision as of 14:46, 29 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==
-		+	<StructureSection load='4qr7' size='340' side='right' caption='[[4qr7]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 4qr7 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qr7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QR7 FirstGlance]. <br>
-	~~Authors~~: ~~Gokulan, K~~.~~, Varughese, K~~.I., ~~Center for Structural Genomics of Infectious Diseases~~ (~~CSGID~~)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qra\|4qra]], [[4qrb\|4qrb]]</td></tr>
-	~~Description~~: ~~Structure and specificity of~~ L-D-~~Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance~~: ~~Calcium binding promotes dimer formation~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qr7 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Varughese~~, K.I]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Structural genomic]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (~~Csgid)]]	+	[[Category: Varughese, K I]]
		+	[[Category: Beta-lactamase]]
		+	[[Category: Csgid]]
		+	[[Category: D-d-transpeptidase]]
		+	[[Category: Enzyme function initiative]]
		+	[[Category: Hydrolase]]
		+	[[Category: Imipenem]]
		+	[[Category: L-d-transpeptidase]]
		+	[[Category: Meropenem]]
		+	[[Category: Peptidoglycan]]
		+	[[Category: Single anomalous diffraction]]

OCA at 16:03, 24 December 2014

OCA — Wed, 24 Dec 2014 16:03:19 GMT

←Older revision		Revision as of 16:03, 24 December 2014
Line 6:		Line 6:

	Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation		Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
		+	[[Category: Unreleased Structures]]
		+	[[Category: Varughese, K.I]]
		+	[[Category: Gokulan, K]]
		+	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]

OCA at 01:10, 7 August 2014

OCA — Thu, 07 Aug 2014 01:10:27 GMT

←Older revision		Revision as of 01:10, 7 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qr7 is ON HOLD	+	The entry 4qr7 is ON HOLD until Paper Publication

	Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID)		Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID)

	Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation		Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation

OCA: Protected "4qr7" [edit=sysop:move=sysop]

OCA — Wed, 09 Jul 2014 06:53:04 GMT

Protected "4qr7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 9 July 2014

OCA: New page: '''Unreleased structure''' The entry 4qr7 is ON HOLD Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID) Description: Structure and spe...

OCA — Wed, 09 Jul 2014 06:53:03 GMT

New page: '''Unreleased structure''' The entry 4qr7 is ON HOLD Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID) Description: Structure and spe...

New page

'''Unreleased structure'''

The entry 4qr7 is ON HOLD

Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation