4qsv - Revision history

OCA at 17:37, 20 September 2023

OCA — Wed, 20 Sep 2023 17:37:43 GMT

←Older revision		Revision as of 17:37, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QSV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [https://pdbe.org/4qsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [https://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [https://pdbe.org/4qsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [https://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:50, 22 February 2023

OCA — Wed, 22 Feb 2023 13:50:50 GMT

←Older revision		Revision as of 13:50, 22 February 2023
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	<StructureSection load='4qsv' size='340' side='right'caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4qsv' size='340' side='right'caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QSV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [https://pdbe.org/4qsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [https://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [~~http~~://pdbe.org/4qsv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>

	==See Also==		==See Also==
Line 19:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenosinetriphosphatase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Felletar I]]
-	[[Category: Felletar, I]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Structural genomic]]~~	+
-	~~[[Category: Actyl-lysine binding]]~~	+
-	~~[[Category: Atpase family aaa domain-containing protein 2]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:31, 24 April 2019

OCA — Wed, 24 Apr 2019 09:31:14 GMT

←Older revision		Revision as of 09:31, 24 April 2019
Line 1:		Line 1:

	==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine==		==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine==
-	<StructureSection load='4qsv' size='340' side='right' caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4qsv' size='340' side='right'caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://pdbe.org/4qsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://pdbe.org/4qsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>		[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Adenosinetriphosphatase]]		[[Category: Adenosinetriphosphatase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 16:37, 11 August 2016

OCA — Thu, 11 Aug 2016 16:37:29 GMT

←Older revision		Revision as of 16:37, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine==		==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine==
	<StructureSection load='4qsv' size='340' side='right' caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4qsv' size='340' side='right' caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://pdbe.org/4qsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:21, 25 December 2014

OCA — Thu, 25 Dec 2014 20:21:24 GMT

←Older revision		Revision as of 20:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Adenosinetriphosphatase]]		[[Category: Adenosinetriphosphatase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Felletar, I.]]	+	[[Category: Felletar, I]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Actyl-lysine binding]]		[[Category: Actyl-lysine binding]]
	[[Category: Atpase family aaa domain-containing protein 2]]		[[Category: Atpase family aaa domain-containing protein 2]]

OCA at 08:14, 23 July 2014

OCA — Wed, 23 Jul 2014 08:14:12 GMT

←Older revision		Revision as of 08:14, 23 July 2014
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-	'''~~Unreleased structure~~'''	+	==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine==
-		+	<StructureSection load='4qsv' size='340' side='right' caption='[[4qsv]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~The entry~~ 4qsv is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qsv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSV FirstGlance]. <br>
-	~~Authors~~: ~~Chaikuad~~, A., ~~Felletar~~, I., ~~von Delft~~, F., Arrowsmith, C.H., ~~Edwards~~, A.M., ~~Bountra, C~~., Knapp, S., Structural Genomics Consortium ~~(SGC)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qsp\|4qsp]], [[4qsq\|4qsq]], [[4qsr\|4qsr]], [[4qss\|4qss]], [[4qst\|4qst]], [[4qsu\|4qsu]], [[4qsw\|4qsw]], [[4qsx\|4qsx]]</td></tr>
-	~~Description~~: ~~Structure of the bromodomain of human ATPase~~ family ~~AAA~~ domain-containing protein 2 ~~(ATAD2) in complex with thymidine~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qsv RCSB], [http://www.ebi.ac.uk/pdbsum/4qsv PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenosinetriphosphatase]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Felletar, I.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Actyl-lysine binding]]
		+	[[Category: Atpase family aaa domain-containing protein 2]]
		+	[[Category: Bromodomain]]
		+	[[Category: Epigenetic]]
		+	[[Category: Signaling protein]]

OCA: Protected "4qsv" [edit=sysop:move=sysop]

OCA — Wed, 16 Jul 2014 09:48:14 GMT

Protected "4qsv" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:48, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4qsv is ON HOLD Authors: Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Con...

OCA — Wed, 16 Jul 2014 09:48:13 GMT

New page: '''Unreleased structure''' The entry 4qsv is ON HOLD Authors: Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Con...

New page

'''Unreleased structure'''

The entry 4qsv is ON HOLD

Authors: Chaikuad, A., Felletar, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine