4qzh - Revision history

OCA at 17:41, 20 September 2023

OCA — Wed, 20 Sep 2023 17:41:32 GMT

←Older revision		Revision as of 17:41, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [https://pdbe.org/4qzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [https://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [https://pdbe.org/4qzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [https://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 14:00, 22 February 2023

OCA — Wed, 22 Feb 2023 14:00:52 GMT

←Older revision		Revision as of 14:00, 22 February 2023
Line 1:		Line 1:

	==Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair==		==Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair==
-	<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4qzh' size='340' side='right'caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [https://pdbe.org/4qzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [https://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [~~http~~://pdbe.org/4qzh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.	+	[https://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA nucleotidylexotransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Delarue, M]]	+	[[Category: Delarue M]]
-	[[Category: Gouge, J]]	+	[[Category: Gouge J]]
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Terminal deoxynucleotidyltransferase]]~~	+
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 05:51, 16 November 2017

OCA — Thu, 16 Nov 2017 05:51:16 GMT

←Older revision		Revision as of 05:51, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [http://pdbe.org/4qzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [http://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [http://pdbe.org/4qzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [http://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: DNA nucleotidylexotransferase]]		[[Category: DNA nucleotidylexotransferase]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Delarue, M]]		[[Category: Delarue, M]]
	[[Category: Gouge, J]]		[[Category: Gouge, J]]

OCA at 02:07, 11 March 2017

OCA — Sat, 11 Mar 2017 02:07:52 GMT

←Older revision		Revision as of 02:07, 11 March 2017
Line 1:		Line 1:
		+
	==Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair==		==Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair==
	<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [http://www.ebi.ac.uk/pdbsum/4qzh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [http://pdbe.org/4qzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [http://www.ebi.ac.uk/pdbsum/4qzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qzh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:01, 10 June 2015

OCA — Wed, 10 Jun 2015 14:01:46 GMT

←Older revision		Revision as of 14:01, 10 June 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair==
		+	<StructureSection load='4qzh' size='340' side='right' caption='[[4qzh]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qzh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i27\|4i27]], [[1jms\|1jms]], [[4qz8\|4qz8]], [[4qz9\|4qz9]], [[4qza\|4qza]], [[4qzb\|4qzb]], [[4qzc\|4qzc]], [[4qzd\|4qzd]], [[4qze\|4qze]], [[4qzf\|4qzf]], [[4qzg\|4qzg]], [[4qzi\|4qzi]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzh RCSB], [http://www.ebi.ac.uk/pdbsum/4qzh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eukaryotic DNA polymerase mu of the PolX family can promote the association of the two 3'-protruding ends of a DNA double-strand break (DSB) being repaired (DNA synapsis) even in the absence of the core non-homologous end-joining (NHEJ) machinery. Here, we show that terminal deoxynucleotidyltransferase (TdT), a closely related PolX involved in V(D)J recombination, has the same property. We solved its crystal structure with an annealed DNA synapsis containing one micro-homology (MH) base pair and one nascent base pair. This structure reveals how the N-terminal domain and Loop 1 of Tdt cooperate for bridging the two DNA ends, providing a templating base in trans and limiting the MH search region to only two base pairs. A network of ordered water molecules is proposed to assist the incorporation of any nucleotide independently of the in trans templating base. These data are consistent with a recent model that explains the statistics of sequences synthesized in vivo by Tdt based solely on this dinucleotide step. Site-directed mutagenesis and functional tests suggest that this structural model is also valid for Pol mu during NHEJ.

-	~~The entry 4qzh is ON HOLD until Paper Publication~~	+	Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.,Gouge J, Rosario S, Romain F, Poitevin F, Beguin P, Delarue M EMBO J. 2015 Apr 15;34(8):1126-42. doi: 10.15252/embj.201489643. Epub 2015 Mar, 11. PMID:25762590<ref>PMID:25762590</ref>

-	~~Authors: Gouge~~, J.~~, Delarue, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA nucleotidylexotransferase]]
		+	[[Category: Delarue, M]]
	[[Category: Gouge, J]]		[[Category: Gouge, J]]
-	[[Category: ~~Delarue, M~~]]	+	[[Category: Nucleus]]
		+	[[Category: Terminal deoxynucleotidyltransferase]]
		+	[[Category: Transferase-dna complex]]

OCA at 16:17, 24 December 2014

OCA — Wed, 24 Dec 2014 16:17:38 GMT

←Older revision		Revision as of 16:17, 24 December 2014
Line 6:		Line 6:

	Description: Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair		Description: Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair
		+	[[Category: Unreleased Structures]]
		+	[[Category: Gouge, J]]
		+	[[Category: Delarue, M]]

OCA at 04:10, 4 September 2014

OCA — Thu, 04 Sep 2014 04:10:20 GMT

←Older revision		Revision as of 04:10, 4 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qzh is ON HOLD	+	The entry 4qzh is ON HOLD until Paper Publication

	Authors: Gouge, J., Delarue, M.		Authors: Gouge, J., Delarue, M.

	Description: Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair		Description: Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair

OCA at 14:43, 20 August 2014

OCA — Wed, 20 Aug 2014 14:43:32 GMT

←Older revision		Revision as of 14:43, 20 August 2014
Line 3:		Line 3:
	The entry 4qzh is ON HOLD		The entry 4qzh is ON HOLD

-	Authors: Gouge J., Delarue M.	+	Authors: Gouge, J., Delarue, M.

-	Description: ~~mouse~~ Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair	+	Description: Mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair

OCA: Protected "4qzh" [edit=sysop:move=sysop]

OCA — Thu, 07 Aug 2014 01:15:39 GMT

Protected "4qzh" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:15, 7 August 2014

OCA: New page: '''Unreleased structure''' The entry 4qzh is ON HOLD Authors: Gouge J., Delarue M. Description: mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair

OCA — Thu, 07 Aug 2014 01:15:37 GMT

New page: '''Unreleased structure''' The entry 4qzh is ON HOLD Authors: Gouge J., Delarue M. Description: mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair

New page

'''Unreleased structure'''

The entry 4qzh is ON HOLD

Authors: Gouge J., Delarue M.

Description: mouse Tdt, F401A mutant, in complex with a DSB substrate, C-T base pair