4qzv - Revision history

OCA at 14:01, 22 February 2023

OCA — Wed, 22 Feb 2023 14:01:08 GMT

←Older revision		Revision as of 14:01, 22 February 2023
Line 3:		Line 3:
	<StructureSection load='4qzv' size='340' side='right'caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4qzv' size='340' side='right'caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bchk4 Bchk4~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tylonycteris_bat_coronavirus_HKU4 Tylonycteris bat coronavirus HKU4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [https://pdbe.org/4qzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [https://www.ebi.ac.uk/pdbsum/4qzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), S, 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=694007 BCHK4])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [~~http~~://pdbe.org/4qzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref> [[http://www.uniprot.org/uniprot/SPIKE_BCHK4 SPIKE_BCHK4]] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).	+	[https://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]	+	*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
		+	*[[Sandbox 3001\|Sandbox 3001]]
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bchk4]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Dipeptidyl-peptidase IV]]~~	+
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gao, F G~~]]	+	[[Category: Tylonycteris bat coronavirus HKU4]]
-	[[Category: ~~Lu, G W~~]]	+	[[Category: Gao FG]]
-	[[Category: ~~Qi, J X~~]]	+	[[Category: Lu GW]]
-	[[Category: ~~Wang, Q H~~]]	+	[[Category: Qi JX]]
-	[[Category: ~~8-bladed beta-propeller domain]]~~	+	[[Category: Wang QH]]
-	~~[[Category: Alpha/beta hydrolase domain]]~~	+
-	~~[[Category: Blades iv and v]]~~	+
-	~~[[Category: Cd26 beta-propeller]]~~	+
-	~~[[Category: Hydrolase-viral protein complex~~]]	+

OCA at 09:09, 24 April 2019

OCA — Wed, 24 Apr 2019 09:09:32 GMT

←Older revision		Revision as of 09:09, 24 April 2019
Line 1:		Line 1:

	==Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry==		==Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry==
-	<StructureSection load='4qzv' size='340' side='right' caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='4qzv' size='340' side='right'caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bchk4 Bchk4] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), S, 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=694007 BCHK4])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://pdbe.org/4qzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://pdbe.org/4qzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzv ProSAT]</span></td></tr>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bchk4]]
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gao, F G]]		[[Category: Gao, F G]]
	[[Category: Lu, G W]]		[[Category: Lu, G W]]

OCA at 20:32, 4 August 2016

OCA — Thu, 04 Aug 2016 20:32:57 GMT

←Older revision		Revision as of 20:32, 4 August 2016
Line 1:		Line 1:
		+
	==Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry==		==Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry==
	<StructureSection load='4qzv' size='340' side='right' caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4qzv' size='340' side='right' caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://pdbe.org/4qzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qzv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:55, 25 December 2014

OCA — Thu, 25 Dec 2014 12:55:10 GMT

←Older revision		Revision as of 12:55, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref> [[http://www.uniprot.org/uniprot/SPIKE_BCHK4 SPIKE_BCHK4]] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
-	[[Category: Gao, F G.]]	+	[[Category: Gao, F G]]
-	[[Category: Lu, G W.]]	+	[[Category: Lu, G W]]
-	[[Category: Qi, J X.]]	+	[[Category: Qi, J X]]
-	[[Category: Wang, Q H.]]	+	[[Category: Wang, Q H]]
	[[Category: 8-bladed beta-propeller domain]]		[[Category: 8-bladed beta-propeller domain]]
	[[Category: Alpha/beta hydrolase domain]]		[[Category: Alpha/beta hydrolase domain]]

OCA at 11:22, 29 October 2014

OCA — Wed, 29 Oct 2014 11:22:06 GMT

←Older revision		Revision as of 11:22, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry==
		+	<StructureSection load='4qzv' size='340' side='right' caption='[[4qzv]], [[Resolution\|resolution]] 2.59Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qzv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kr0\|4kr0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzv RCSB], [http://www.ebi.ac.uk/pdbsum/4qzv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV) is phylogenetically closely related to the bat coronaviruses (BatCoVs) HKU4 and HKU5. However, the evolutionary pathway of MERS-CoV is still unclear. A receptor binding domain (RBD) in the MERS-CoV envelope-embedded spike protein specifically engages human CD26 (hCD26) to initiate viral entry. The high sequence identity in the viral spike protein prompted us to investigate if HKU4 and HKU5 can recognize hCD26 for cell entry. We found that HKU4-RBD, but not HKU5-RBD, binds to hCD26, and pseudotyped viruses embedding HKU4 spike can infect cells via hCD26 recognition. The structure of the HKU4-RBD/hCD26 complex revealed a hCD26-binding mode similar overall to that observed for MERS-RBD. HKU4-RBD, however, is less adapted to hCD26 than MERS-RBD, explaining its lower affinity for receptor binding. Our findings support a bat origin for MERS-CoV and indicate the need for surveillance of HKU4-related viruses in bats.

-	~~The entry 4qzv is ON HOLD~~	+	Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.,Wang Q, Qi J, Yuan Y, Xuan Y, Han P, Wan Y, Ji W, Li Y, Wu Y, Wang J, Iwamoto A, Woo PC, Yuen KY, Yan J, Lu G, Gao GF Cell Host Microbe. 2014 Sep 10;16(3):328-37. doi: 10.1016/j.chom.2014.08.009. PMID:25211075<ref>PMID:25211075</ref>

-	~~Authors~~: Gao, F.G., ~~Wang, Q~~.~~H.,~~ Qi, J.X., ~~Lu, G.W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Bat~~-~~derived coronavirus HKU4 uses MERS~~-~~CoV receptor human CD26 for cell entry~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dipeptidyl-peptidase IV]]
		+	[[Category: Gao, F G.]]
		+	[[Category: Lu, G W.]]
		+	[[Category: Qi, J X.]]
		+	[[Category: Wang, Q H.]]
		+	[[Category: 8-bladed beta-propeller domain]]
		+	[[Category: Alpha/beta hydrolase domain]]
		+	[[Category: Blades iv and v]]
		+	[[Category: Cd26 beta-propeller]]
		+	[[Category: Hydrolase-viral protein complex]]

OCA: Protected "4qzv" [edit=sysop:move=sysop]

OCA — Thu, 07 Aug 2014 01:16:06 GMT

Protected "4qzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:16, 7 August 2014

OCA: New page: '''Unreleased structure''' The entry 4qzv is ON HOLD Authors: Gao, F.G., Wang, Q.H., Qi, J.X., Lu, G.W. Description: Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for ...

OCA — Thu, 07 Aug 2014 01:16:05 GMT

New page: '''Unreleased structure''' The entry 4qzv is ON HOLD Authors: Gao, F.G., Wang, Q.H., Qi, J.X., Lu, G.W. Description: Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for ...

New page

'''Unreleased structure'''

The entry 4qzv is ON HOLD

Authors: Gao, F.G., Wang, Q.H., Qi, J.X., Lu, G.W.

Description: Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry