4r3i - Revision history

OCA at 12:50, 1 March 2024

OCA — Fri, 01 Mar 2024 12:50:03 GMT

←Older revision		Revision as of 12:50, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [https://pdbe.org/4r3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [https://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [https://pdbe.org/4r3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [https://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>		[https://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, a member of the YTH domain family, and its complex with an m6A-containing RNA. Our structural studies, together with transcriptome-wide identification of YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m6A-YTH binding but also explain the preferential recognition of the GG(m6A)C sequences by YTHDC1.
-
-	Structural basis for selective binding of mA RNA by the YTHDC1 YTH domain.,Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J Nat Chem Biol. 2014 Sep 21. doi: 10.1038/nchembio.1654. PMID:25242552<ref>PMID:25242552</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4r3i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:38, 2 March 2023

OCA — Thu, 02 Mar 2023 06:38:44 GMT

←Older revision		Revision as of 06:38, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4r3i' size='340' side='right'caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4r3i' size='340' side='right'caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4R3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [https://pdbe.org/4r3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [https://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">YTHDC1, KIAA1966, YT521 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [~~http~~://pdbe.org/4r3i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>	+	[https://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Bountra, C]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Bountra C]]
-	[[Category: Li, Y]]	+	[[Category: Edwards AM]]
-	[[Category: Liu, K]]	+	[[Category: Li Y]]
-	[[Category: Min, J]]	+	[[Category: Liu K]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Min J]]
-	[[Category: Tempel, W]]	+	[[Category: Tempel W]]
-	[[Category: Xu, C]]	+	[[Category: Xu C]]
-	~~[[Category: Rna binding protein-rna complex]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 10:02, 1 May 2019

OCA — Wed, 01 May 2019 10:02:50 GMT

←Older revision		Revision as of 10:02, 1 May 2019
Line 1:		Line 1:

	==The crystal structure of an RNA complex==		==The crystal structure of an RNA complex==
-	<StructureSection load='4r3i' size='340' side='right' caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4r3i' size='340' side='right'caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YTHDC1, KIAA1966, YT521 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://pdbe.org/4r3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://pdbe.org/4r3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 17:31, 18 January 2017

OCA — Wed, 18 Jan 2017 17:31:42 GMT

←Older revision		Revision as of 17:31, 18 January 2017
Line 1:		Line 1:
		+
	==The crystal structure of an RNA complex==		==The crystal structure of an RNA complex==
	<StructureSection load='4r3i' size='340' side='right' caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4r3i' size='340' side='right' caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://pdbe.org/4r3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4r3i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:46, 25 December 2014

OCA — Thu, 25 Dec 2014 16:46:03 GMT

←Older revision		Revision as of 16:46, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:41, 19 November 2014

OCA — Wed, 19 Nov 2014 10:41:58 GMT

←Older revision		Revision as of 10:41, 19 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Liu, K.]]	+	[[Category: Liu, K]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Xu, C.]]	+	[[Category: Xu, C]]
	[[Category: Rna binding protein-rna complex]]		[[Category: Rna binding protein-rna complex]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 22:30, 1 October 2014

OCA — Wed, 01 Oct 2014 22:30:15 GMT

←Older revision		Revision as of 22:30, 1 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The crystal structure of an RNA complex==
		+	<StructureSection load='4r3i' size='340' side='right' caption='[[4r3i]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3h\|4r3h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, a member of the YTH domain family, and its complex with an m6A-containing RNA. Our structural studies, together with transcriptome-wide identification of YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m6A-YTH binding but also explain the preferential recognition of the GG(m6A)C sequences by YTHDC1.

-	~~The entry 4r3i is ON HOLD until~~ Sep ~~24 2015~~	+	Structural basis for selective binding of mA RNA by the YTHDC1 YTH domain.,Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J Nat Chem Biol. 2014 Sep 21. doi: 10.1038/nchembio.1654. PMID:25242552<ref>PMID:25242552</ref>

-	~~Authors: Tempel~~, W.~~, Xu, C~~.~~, Liu, K~~.~~, Li, Y., Bountra, C.,~~ Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium ~~(SGC)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The crystal structure of an RNA~~ complex	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Li, Y.]]
		+	[[Category: Liu, K.]]
		+	[[Category: Min, J.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Xu, C.]]
		+	[[Category: Rna binding protein-rna complex]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]

OCA at 08:21, 10 September 2014

OCA — Wed, 10 Sep 2014 08:21:46 GMT

←Older revision		Revision as of 08:21, 10 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4r3i is ON HOLD	+	The entry 4r3i is ON HOLD until Sep 24 2015

	Authors: Tempel, W., Xu, C., Liu, K., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)		Authors: Tempel, W., Xu, C., Liu, K., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

	Description: The crystal structure of an RNA complex		Description: The crystal structure of an RNA complex

OCA at 04:12, 4 September 2014

OCA — Thu, 04 Sep 2014 04:12:33 GMT

←Older revision		Revision as of 04:12, 4 September 2014
Line 3:		Line 3:
	The entry 4r3i is ON HOLD		The entry 4r3i is ON HOLD

-	Authors: Tempel, W., Xu, C., Liu, K., Li, Y., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Genomics Consortium (SGC)	+	Authors: Tempel, W., Xu, C., Liu, K., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

	Description: The crystal structure of an RNA complex		Description: The crystal structure of an RNA complex

OCA: Protected "4r3i" [edit=sysop:move=sysop]

OCA — Wed, 27 Aug 2014 06:58:10 GMT

Protected "4r3i" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 27 August 2014