4r3s - Revision history

OCA at 15:11, 8 November 2023

OCA — Wed, 08 Nov 2023 15:11:53 GMT

←Older revision		Revision as of 15:11, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [https://pdbe.org/4r3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [https://www.ebi.ac.uk/pdbsum/4r3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [https://pdbe.org/4r3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [https://www.ebi.ac.uk/pdbsum/4r3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:39, 2 March 2023

OCA — Thu, 02 Mar 2023 06:39:01 GMT

←Older revision		Revision as of 06:39, 2 March 2023
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	<StructureSection load='4r3s' size='340' side='right'caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4r3s' size='340' side='right'caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4R3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3S FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [https://pdbe.org/4r3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [https://www.ebi.ac.uk/pdbsum/4r3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3s ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [~~http~~://pdbe.org/4r3s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4r3s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3s ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9GQZ3_PLAFA Q9GQZ3_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4r3s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4r3s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Anders~~, R F~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Bankala, K]]	+	[[Category: Anders RF]]
-	[[Category: Christ, D]]	+	[[Category: Bankala K]]
-	[[Category: Drinkwater, N]]	+	[[Category: Christ D]]
-	[[Category: MacRaild~~, C A~~]]	+	[[Category: Drinkwater N]]
-	[[Category: McGowan, S]]	+	[[Category: MacRaild CA]]
-	[[Category: Morales~~, R A.V~~]]	+	[[Category: McGowan S]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Morales RAV]]
-	[[Category: Rouet, R]]	+	[[Category: Norton RS]]
-	[[Category: Seow, J]]	+	[[Category: Rouet R]]
-	~~[[Category: Immune system]]~~	+	[[Category: Seow J]]
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: N-terminal msp2]]~~	+
-	~~[[Category: Unstructured antigen~~]]	+

OCA at 10:22, 1 May 2019

OCA — Wed, 01 May 2019 10:22:41 GMT

←Older revision		Revision as of 10:22, 1 May 2019
Line 1:		Line 1:

	==Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23==		==Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23==
-	<StructureSection load='4r3s' size='340' side='right' caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4r3s' size='340' side='right'caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3S FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Anders, R F]]		[[Category: Anders, R F]]
	[[Category: Bankala, K]]		[[Category: Bankala, K]]

OCA at 17:27, 9 March 2017

OCA — Thu, 09 Mar 2017 17:27:42 GMT

←Older revision		Revision as of 17:27, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23==		==Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23==
	<StructureSection load='4r3s' size='340' side='right' caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4r3s' size='340' side='right' caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [http://www.ebi.ac.uk/pdbsum/4r3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [http://pdbe.org/4r3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [http://www.ebi.ac.uk/pdbsum/4r3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4r3s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:40, 3 June 2015

OCA — Wed, 03 Jun 2015 12:40:44 GMT

←Older revision		Revision as of 12:40, 3 June 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23==
		+	<StructureSection load='4r3s' size='340' side='right' caption='[[4r3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4r3s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3S FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qxt\|4qxt]], [[4qyo\|4qyo]], [[4qy8\|4qy8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3s RCSB], [http://www.ebi.ac.uk/pdbsum/4r3s PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Merozoite surface protein 2 (MSP2) is an intrinsically disordered, membrane-anchored antigen of the malaria parasite Plasmodium falciparum. MSP2 can elicit a protective, albeit strain-specific, antibody response in humans. Antibodies are generated to the conserved N- and C-terminal regions but many of these react poorly with the native antigen on the parasite surface. Here we demonstrate that recognition of a conserved N-terminal epitope by mAb 6D8 is incompatible with the membrane-bound conformation of that region, suggesting a mechanism by which native MSP2 escapes antibody recognition. Furthermore, crystal structures and NMR spectroscopy identify transient, strain-specific interactions between the 6D8 antibody and regions of MSP2 beyond the conserved epitope. These interactions account for the differential affinity of 6D8 for the two allelic families of MSP2, even though 6D8 binds to a fully conserved epitope. These results highlight unappreciated mechanisms that may modulate the specificity and efficacy of immune responses towards disordered antigens.

-	~~The entry 4r3s is ON HOLD until Paper Publication~~	+	Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate.,Morales RA, MacRaild CA, Seow J, Krishnarjuna B, Drinkwater N, Rouet R, Anders RF, Christ D, McGowan S, Norton RS Sci Rep. 2015 May 12;5:10103. doi: 10.1038/srep10103. PMID:25965408<ref>PMID:25965408</ref>

-	~~Authors: Morales~~, R.~~A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan,~~ S.~~, Rouet, R., Christ, D., Anders, R.F., Norton, R.S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Macraild~~, ~~C.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Anders, R F]]
	[[Category: Bankala, K]]		[[Category: Bankala, K]]
		+	[[Category: Christ, D]]
		+	[[Category: Drinkwater, N]]
		+	[[Category: MacRaild, C A]]
		+	[[Category: McGowan, S]]
		+	[[Category: Morales, R A.V]]
		+	[[Category: Norton, R S]]
	[[Category: Rouet, R]]		[[Category: Rouet, R]]
-	[[Category: Drinkwater, N]]
	[[Category: Seow, J]]		[[Category: Seow, J]]
-	[[Category: ~~Christ, D~~]]	+	[[Category: Immune system]]
-	[[Category: ~~Morales, R.A.V~~]]	+	[[Category: Immunoglobulin fold]]
-	[[Category: ~~Norton, R.S~~]]	+	[[Category: N-terminal msp2]]
-	[[Category: ~~Anders, R.F]]~~	+	[[Category: Unstructured antigen]]
-	~~[[Category: Mcgowan, S~~]]	+

OCA at 16:27, 24 December 2014

OCA — Wed, 24 Dec 2014 16:27:05 GMT

←Older revision		Revision as of 16:27, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23		Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23
		+	[[Category: Unreleased Structures]]
		+	[[Category: Macraild, C.A]]
		+	[[Category: Bankala, K]]
		+	[[Category: Rouet, R]]
		+	[[Category: Drinkwater, N]]
		+	[[Category: Seow, J]]
		+	[[Category: Christ, D]]
		+	[[Category: Morales, R.A.V]]
		+	[[Category: Norton, R.S]]
		+	[[Category: Anders, R.F]]
		+	[[Category: Mcgowan, S]]

OCA at 08:21, 10 September 2014

OCA — Wed, 10 Sep 2014 08:21:53 GMT

←Older revision		Revision as of 08:21, 10 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4r3s is ON HOLD	+	The entry 4r3s is ON HOLD until Paper Publication

	Authors: Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S.		Authors: Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S.

	Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23		Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23

OCA: Protected "4r3s" [edit=sysop:move=sysop]

OCA — Wed, 27 Aug 2014 06:58:46 GMT

Protected "4r3s" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 27 August 2014

OCA: New page: '''Unreleased structure''' The entry 4r3s is ON HOLD Authors: Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., N...

OCA — Wed, 27 Aug 2014 06:58:44 GMT

New page: '''Unreleased structure''' The entry 4r3s is ON HOLD Authors: Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., N...

New page

'''Unreleased structure'''

The entry 4r3s is ON HOLD

Authors: Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S.

Description: Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23