4r5m - Revision history

OCA at 17:44, 20 September 2023

OCA — Wed, 20 Sep 2023 17:44:31 GMT

←Older revision		Revision as of 17:44, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [https://pdbe.org/4r5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [https://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [https://pdbe.org/4r5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [https://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:41, 2 March 2023

OCA — Thu, 02 Mar 2023 06:41:20 GMT

←Older revision		Revision as of 06:41, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4r5m' size='340' side='right'caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4r5m' size='340' side='right'caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibch Vibch~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4R5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [https://pdbe.org/4r5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [https://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd1, Q9KQG2, VC_2036 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [~~http~~://pdbe.org/4r5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DHAS1_VIBCH DHAS1_VIBCH]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>	+	[https://www.uniprot.org/uniprot/DHAS1_VIBCH DHAS1_VIBCH] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vibch~~]]	+	[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
-	[[Category: Bhansali, P]]	+	[[Category: Bhansali P]]
-	[[Category: Pavlovsky~~, A G~~]]	+	[[Category: Pavlovsky AG]]
-	[[Category: Thangavelu, B]]	+	[[Category: Thangavelu B]]
-	[[Category: Viola~~, R E]]~~	+	[[Category: Viola RE]]
-	~~[[Category: Cypoplasm]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 09:40, 1 May 2019

OCA — Wed, 01 May 2019 09:40:40 GMT

←Older revision		Revision as of 09:40, 1 May 2019
Line 1:		Line 1:

	==Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid==		==Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid==
-	<StructureSection load='4r5m' size='340' side='right' caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='4r5m' size='340' side='right'caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">asd1, Q9KQG2, VC_2036 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://pdbe.org/4r5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://pdbe.org/4r5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]	+	*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Large Structures]]
		+	[[Category: Vibch]]
	[[Category: Bhansali, P]]		[[Category: Bhansali, P]]
	[[Category: Pavlovsky, A G]]		[[Category: Pavlovsky, A G]]

OCA at 19:08, 4 August 2016

OCA — Thu, 04 Aug 2016 19:08:04 GMT

←Older revision		Revision as of 19:08, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid==		==Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid==
	<StructureSection load='4r5m' size='340' side='right' caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4r5m' size='340' side='right' caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://pdbe.org/4r5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4r5m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:27, 31 December 2014

OCA — Wed, 31 Dec 2014 09:27:40 GMT

←Older revision		Revision as of 09:27, 31 December 2014
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DHAS1_VIBCH DHAS1_VIBCH]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>		[[http://www.uniprot.org/uniprot/DHAS1_VIBCH DHAS1_VIBCH]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aspartate pathway is essential for the production of the amino acids required for protein synthesis and of the metabolites needed in bacterial development. This pathway also leads to the production of several classes of quorum-sensing molecules that can trigger virulence in certain microorganisms. The second enzyme in this pathway, aspartate beta-semialdehyde dehydrogenase (ASADH), is absolutely required for bacterial survival and has been targeted for the design of selective inhibitors. Fragment-library screening has identified a new set of inhibitors that, while they do not resemble the substrates for this reaction, have been shown to bind at the active site of ASADH. Structure-guided development of these lead compounds has produced moderate inhibitors of the target enzyme, with some selectivity observed between the Gram-negative and Gram-positive orthologs of ASADH. However, many of these inhibitor analogs and derivatives have not yet achieved the expected enhanced affinity. Structural characterization of these enzyme-inhibitor complexes has provided detailed explanations for the barriers that interfere with optimal binding. Despite binding in the same active-site region, significant changes are observed in the orientation of these bound inhibitors that are caused by relatively modest structural alterations. Taken together, these studies present a cautionary tale for issues that can arise in the systematic approach to the modification of lead compounds that are being used to develop potent inhibitors.
		+
		+	A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.,Pavlovsky AG, Thangavelu B, Bhansali P, Viola RE Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3244-52. doi:, 10.1107/S1399004714023979. Epub 2014 Nov 22. PMID:25478842<ref>PMID:25478842</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:15, 25 December 2014

OCA — Thu, 25 Dec 2014 12:15:11 GMT

←Older revision		Revision as of 12:15, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DHAS1_VIBCH DHAS1_VIBCH]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:12071715</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:25, 10 December 2014

OCA — Wed, 10 Dec 2014 16:25:04 GMT

←Older revision		Revision as of 16:25, 10 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid==
-		+	<StructureSection load='4r5m' size='340' side='right' caption='[[4r5m]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~The entry~~ 4r5m is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4r5m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5M FirstGlance]. <br>
-	~~Authors~~: ~~Pavlovsky, A~~.G., ~~Thangavelu~~, B., ~~Bhansali~~, P., ~~Viola~~, ~~R.E.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NO:4-NITRO-2-PHOSPHONOBENZOIC+ACID'>4NO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r3w\|4r3w]], [[4r41\|4r41]], [[4r4j\|4r4j]], [[4r51\|4r51]], [[4r54\|4r54]], [[4r5h\|4r5h]], [[4r3n\|4r3n]]</td></tr>
-	~~Description~~: ~~Crystal structure of Vc~~-Aspartate ~~beta~~-semialdehyde-dehydrogenase with ~~NADP and 4-Nitro~~-2-~~Phosphono~~-~~Benzoic acid~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r5m RCSB], [http://www.ebi.ac.uk/pdbsum/4r5m PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Bhansali, P]]
		+	[[Category: Pavlovsky, A G]]
		+	[[Category: Thangavelu, B]]
		+	[[Category: Viola, R E]]
		+	[[Category: Cypoplasm]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA at 06:40, 26 November 2014

OCA — Wed, 26 Nov 2014 06:40:24 GMT

←Older revision		Revision as of 06:40, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4r5m is ON HOLD	+	The entry 4r5m is ON HOLD until Paper Publication

	Authors: Pavlovsky, A.G., Thangavelu, B., Bhansali, P., Viola, R.E.		Authors: Pavlovsky, A.G., Thangavelu, B., Bhansali, P., Viola, R.E.

	Description: Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid		Description: Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid

OCA at 04:15, 4 September 2014

OCA — Thu, 04 Sep 2014 04:15:22 GMT

←Older revision		Revision as of 04:15, 4 September 2014
Line 3:		Line 3:
	The entry 4r5m is ON HOLD		The entry 4r5m is ON HOLD

-	Authors: Pavlovsky,A.G., ~~Bharani~~ Thangavelu, ~~Pravin~~ Bhansali , Viola,R.E.	+	Authors: Pavlovsky, A.G., Thangavelu, B., Bhansali, P., Viola, R.E.

	Description: Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid		Description: Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid

OCA: Protected "4r5m" [edit=sysop:move=sysop]

OCA — Wed, 27 Aug 2014 07:02:47 GMT

Protected "4r5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 27 August 2014