4r95 - Revision history

OCA at 06:46, 2 March 2023

OCA — Thu, 02 Mar 2023 06:46:04 GMT

←Older revision		Revision as of 06:46, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4r95' size='340' side='right'caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='4r95' size='340' side='right'caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r95]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R95 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4R95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R95 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KW:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-2-IMINO-3-METHYL-5-{[(1S,3R)-3-(QUINOLIN-2-YLAMINO)CYCLOHEXYL]METHYL}IMIDAZOLIDIN-4-ONE'>3KW</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KW:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-2-IMINO-3-METHYL-5-{[(1S,3R)-3-(QUINOLIN-2-YLAMINO)CYCLOHEXYL]METHYL}IMIDAZOLIDIN-4-ONE'>3KW</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [https://pdbe.org/4r95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [https://www.ebi.ac.uk/pdbsum/4r95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r95 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [~~http~~://pdbe.org/4r95 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4r95 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4r95 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Memapsin 2]]~~	+	[[Category: Caldwell JP]]
-	[[Category: Caldwell~~, J P~~]]	+	[[Category: Orth P]]
-	[[Category: Orth, P]]	+	[[Category: Strickland C]]
-	[[Category: Strickland, C]]	+
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 10:01, 1 May 2019

OCA — Wed, 01 May 2019 10:01:26 GMT

←Older revision		Revision as of 10:01, 1 May 2019
Line 1:		Line 1:

	==BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium==		==BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium==
-	<StructureSection load='4r95' size='340' side='right' caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='4r95' size='340' side='right'caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r95]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R95 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KW:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-2-IMINO-3-METHYL-5-{[(1S,3R)-3-(QUINOLIN-2-YLAMINO)CYCLOHEXYL]METHYL}IMIDAZOLIDIN-4-ONE'>3KW</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KW:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-2-IMINO-3-METHYL-5-{[(1S,3R)-3-(QUINOLIN-2-YLAMINO)CYCLOHEXYL]METHYL}IMIDAZOLIDIN-4-ONE'>3KW</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://pdbe.org/4r95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r95 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://pdbe.org/4r95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r95 ProSAT]</span></td></tr>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Caldwell, J P]]		[[Category: Caldwell, J P]]

OCA at 08:53, 4 August 2016

OCA — Thu, 04 Aug 2016 08:53:40 GMT

←Older revision		Revision as of 08:53, 4 August 2016
Line 1:		Line 1:
		+
	==BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium==		==BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium==
	<StructureSection load='4r95' size='340' side='right' caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='4r95' size='340' side='right' caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://pdbe.org/4r95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4r95" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 25 December 2014

OCA — Thu, 25 Dec 2014 07:32:24 GMT

←Older revision		Revision as of 07:32, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:07, 17 December 2014

OCA — Wed, 17 Dec 2014 10:07:17 GMT

←Older revision		Revision as of 10:07, 17 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synthesis of a series of iminoheterocycles and their structure-activity relationships (SAR) as inhibitors of the aspartyl protease BACE1 will be detailed. An effort to access the S3 subsite directly from the S1 subsite initially yielded compounds with sub-micromolar potency. A subset of compounds from this effort unexpectedly occupied a different binding site and displayed excellent BACE1 affinities. Select compounds from this subset acutely lowered Abeta40 levels upon subcutaneous and oral administration to rats.
		+
		+	Discovery of potent iminoheterocycle BACE1 inhibitors.,Caldwell JP, Mazzola RD, Durkin J, Chen J, Chen X, Favreau L, Kennedy M, Kuvelkar R, Lee J, McHugh N, McKittrick B, Orth P, Stamford A, Strickland C, Voigt J, Wang L, Zhang L, Zhang Q, Zhu Z Bioorg Med Chem Lett. 2014 Oct 23;24(23):5455-5459. doi:, 10.1016/j.bmcl.2014.10.006. PMID:25455483<ref>PMID:25455483</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Caldwell, J P.]]	+	[[Category: Caldwell, J P]]
-	[[Category: Orth, P.]]	+	[[Category: Orth, P]]
-	[[Category: Strickland, C.]]	+	[[Category: Strickland, C]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 09:00, 5 November 2014

OCA — Wed, 05 Nov 2014 09:00:51 GMT

←Older revision		Revision as of 09:00, 5 November 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium==
-		+	<StructureSection load='4r95' size='340' side='right' caption='[[4r95]], [[Resolution\|resolution]] 1.99Å' scene=''>
-	~~The entry 4r95 is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4r95]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R95 FirstGlance]. <br>
-	~~Authors: Orth, P., Strickland, C., Caldwell, J.P.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KW:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-2-IMINO-3-METHYL-5-{[(1S,3R)-3-(QUINOLIN-2-YLAMINO)CYCLOHEXYL]METHYL}IMIDAZOLIDIN-4-ONE'>3KW</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r8y\|4r8y]], [[4r91\|4r91]], [[4r92\|4r92]], [[4r93\|4r93]]</td></tr>
-	~~Description:~~ BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r95 RCSB], [http://www.ebi.ac.uk/pdbsum/4r95 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Memapsin 2]]
		+	[[Category: Caldwell, J P.]]
		+	[[Category: Orth, P.]]
		+	[[Category: Strickland, C.]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:28, 8 October 2014

OCA — Wed, 08 Oct 2014 06:28:44 GMT

←Older revision		Revision as of 06:28, 8 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4r95 is ON HOLD	+	The entry 4r95 is ON HOLD until Paper Publication

	Authors: Orth, P., Strickland, C., Caldwell, J.P.		Authors: Orth, P., Strickland, C., Caldwell, J.P.

	Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium		Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium

OCA at 08:26, 24 September 2014

OCA — Wed, 24 Sep 2014 08:26:24 GMT

←Older revision		Revision as of 08:26, 24 September 2014
Line 3:		Line 3:
	The entry 4r95 is ON HOLD		The entry 4r95 is ON HOLD

-	Authors: Orth,P., Strickland,C., Caldwell,J.P.	+	Authors: Orth, P., Strickland, C., Caldwell, J.P.

	Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium		Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium

OCA: Protected "4r95" [edit=sysop:move=sysop]

OCA — Wed, 10 Sep 2014 08:27:21 GMT

Protected "4r95" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:27, 10 September 2014

OCA: New page: '''Unreleased structure''' The entry 4r95 is ON HOLD Authors: Orth,P., Strickland,C., Caldwell,J.P. Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-imin...

OCA — Wed, 10 Sep 2014 08:27:20 GMT

New page: '''Unreleased structure''' The entry 4r95 is ON HOLD Authors: Orth,P., Strickland,C., Caldwell,J.P. Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-imin...

New page

'''Unreleased structure'''

The entry 4r95 is ON HOLD

Authors: Orth,P., Strickland,C., Caldwell,J.P.

Description: BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium