4rap - Revision history

OCA at 06:47, 2 March 2023

OCA — Thu, 02 Mar 2023 06:47:49 GMT

←Older revision		Revision as of 06:47, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4rap' size='340' side='right'caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4rap' size='340' side='right'caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rap]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoh1 Ecoh1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rap]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_ETEC_H10407 Escherichia coli ETEC H10407]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [https://pdbe.org/4rap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [https://www.ebi.ac.uk/pdbsum/4rap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rap ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tibC, ETEC_2140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316401 ECOH1])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [~~http~~://pdbe.org/4rap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rap ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TIBC_ECOH1 TIBC_ECOH1]] Glycosylates the TibA adhesin.	+	[https://www.uniprot.org/uniprot/TIBC_ECOH1 TIBC_ECOH1] Glycosylates the TibA adhesin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Glycosyltransferase\|Glycosyltransferase]]	+	*[[Glycosyltransferase 3D structures\|Glycosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoh1~~]]	+	[[Category: Escherichia coli ETEC H10407]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lu, Q]]	+	[[Category: Lu Q]]
-	[[Category: Shao, F]]	+	[[Category: Shao F]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	[[Category: Yao, Q]]	+	[[Category: Yao Q]]
-	~~[[Category: Adp-heptose]]~~	+
-	~~[[Category: Gt-b fold]]~~	+
-	~~[[Category: Tiba]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:32, 1 May 2019

OCA — Wed, 01 May 2019 10:32:55 GMT

←Older revision		Revision as of 10:32, 1 May 2019
Line 1:		Line 1:

	==Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407==		==Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407==
-	<StructureSection load='4rap' size='340' side='right' caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>	+	<StructureSection load='4rap' size='340' side='right'caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rap]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoh1 Ecoh1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tibC, ETEC_2140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316401 ECOH1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://pdbe.org/4rap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rap ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://pdbe.org/4rap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rap ProSAT]</span></td></tr>
	</table>		</table>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoh1]]
		+	[[Category: Large Structures]]
	[[Category: Lu, Q]]		[[Category: Lu, Q]]
	[[Category: Shao, F]]		[[Category: Shao, F]]

OCA at 22:25, 4 August 2016

OCA — Thu, 04 Aug 2016 22:25:48 GMT

←Older revision		Revision as of 22:25, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407==		==Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407==
	<StructureSection load='4rap' size='340' side='right' caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>		<StructureSection load='4rap' size='340' side='right' caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://pdbe.org/4rap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rap" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycosyltransferase\|Glycosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:38, 25 December 2014

OCA — Thu, 25 Dec 2014 13:38:00 GMT

←Older revision		Revision as of 13:38, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TIBC_ECOH1 TIBC_ECOH1]] Glycosylates the TibA adhesin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lu, Q.]]	+	[[Category: Lu, Q]]
-	[[Category: Shao, F.]]	+	[[Category: Shao, F]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Yao, Q.]]	+	[[Category: Yao, Q]]
	[[Category: Adp-heptose]]		[[Category: Adp-heptose]]
	[[Category: Gt-b fold]]		[[Category: Gt-b fold]]
	[[Category: Tiba]]		[[Category: Tiba]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:17, 29 October 2014

OCA — Wed, 29 Oct 2014 11:17:13 GMT

←Older revision		Revision as of 11:17, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407==
		+	<StructureSection load='4rap' size='340' side='right' caption='[[4rap]], [[Resolution\|resolution]] 2.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4rap]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4q1q\|4q1q]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rap RCSB], [http://www.ebi.ac.uk/pdbsum/4rap PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A large group of bacterial virulence autotransporters including AIDA-I from diffusely adhering E. coli (DAEC) and TibA from enterotoxigenic E. coli (ETEC) require hyper-glycosylation for functioning. Here we demonstrate that TibC from ETEC harbors a heptosyltransferase activity on TibA and AIDA-I, defining a large family of bacterial autotransporter heptosyltransferases (BAHTs). Crystal structure of TibC reveals a characteristic ring-shape dodecamer. The protomer features an N-terminal beta-barrel, a catalytic domain, a beta-hairpin thumb and a unique iron-finger motif. The iron-finger motif contributes to back-to-back dimerization; six dimers form the ring through beta-hairpin thumb-mediated hand-in-hand contact. Structure of ADP-D, D-heptose-bound TibC reveals a sugar transfer mechanism and also the ligand stereoselectivity determinant. Cryo-EM analyses uncover a TibC-TibA dodecamer/hexamer assembly with two enzyme molecules binding to one TibA substrate. The complex structure also highlights a high efficient hyperglycosylation of six autotransporter substrates simultaneously by the dodecamer enzyme complex.

-	~~The entry 4rap is ON HOLD until Paper Publication~~	+	A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family.,Yao Q, Lu Q, Wan X, Song F, Xu Y, Hu M, Zamyatina A, Liu X, Huang N, Zhu P, Shao F Elife. 2014 Oct 13;3. doi: 10.7554/eLife.03714. PMID:25310236<ref>PMID:25310236</ref>

-	~~Authors: Yao~~, Q., Lu, Q., Xu, Y., ~~Shao, F~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of bacterial iron~~-~~containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lu, Q.]]
		+	[[Category: Shao, F.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Yao, Q.]]
		+	[[Category: Adp-heptose]]
		+	[[Category: Gt-b fold]]
		+	[[Category: Tiba]]
		+	[[Category: Transferase]]

OCA at 23:07, 1 October 2014

OCA — Wed, 01 Oct 2014 23:07:51 GMT

←Older revision		Revision as of 23:07, 1 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rap is ON HOLD	+	The entry 4rap is ON HOLD until Paper Publication

	Authors: Yao, Q., Lu, Q., Xu, Y., Shao, F.		Authors: Yao, Q., Lu, Q., Xu, Y., Shao, F.

	Description: Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407		Description: Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407

OCA: Protected "4rap" [edit=sysop:move=sysop]

OCA — Wed, 24 Sep 2014 08:29:08 GMT

Protected "4rap" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:29, 24 September 2014

OCA: New page: '''Unreleased structure''' The entry 4rap is ON HOLD Authors: Yao, Q., Lu, Q., Xu, Y., Shao, F. Description: Crystal structure of bacterial iron-containing dodecameric glycosyltransfer...

OCA — Wed, 24 Sep 2014 08:29:06 GMT

New page: '''Unreleased structure''' The entry 4rap is ON HOLD Authors: Yao, Q., Lu, Q., Xu, Y., Shao, F. Description: Crystal structure of bacterial iron-containing dodecameric glycosyltransfer...

New page

'''Unreleased structure'''

The entry 4rap is ON HOLD

Authors: Yao, Q., Lu, Q., Xu, Y., Shao, F.

Description: Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407