4rh2 - Revision history

OCA at 17:50, 20 September 2023

OCA — Wed, 20 Sep 2023 17:50:11 GMT

←Older revision		Revision as of 17:50, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RH2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RH2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FC9:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-[({[1-(4-SULFAMOYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}CARBAMOTHIOYL)AMINO]BENZOIC+ACID'>FC9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FC9:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-[({[1-(4-SULFAMOYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}CARBAMOTHIOYL)AMINO]BENZOIC+ACID'>FC9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rh2 OCA], [https://pdbe.org/4rh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rh2 RCSB], [https://www.ebi.ac.uk/pdbsum/4rh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rh2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rh2 OCA], [https://pdbe.org/4rh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rh2 RCSB], [https://www.ebi.ac.uk/pdbsum/4rh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rh2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:56, 2 March 2023

OCA — Thu, 02 Mar 2023 06:56:06 GMT

←Older revision		Revision as of 06:56, 2 March 2023
Line 1:		Line 1:

	==Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid==		==Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid==
-	<StructureSection load='4rh2' size='340' side='right' caption='[[4rh2]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4rh2' size='340' side='right'caption='[[4rh2]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rh2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RH2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RH2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RH2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FC9:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-[({[1-(4-SULFAMOYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}CARBAMOTHIOYL)AMINO]BENZOIC+ACID'>FC9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FC9:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-[({[1-(4-SULFAMOYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}CARBAMOTHIOYL)AMINO]BENZOIC+ACID'>FC9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rh2 OCA], [https://pdbe.org/4rh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rh2 RCSB], [https://www.ebi.ac.uk/pdbsum/4rh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rh2 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rh2 OCA], [~~http~~://pdbe.org/4rh2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rh2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rh2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rh2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Ferraroni, M]]	+	[[Category: Ferraroni M]]
-	~~[[Category: Lyase~~]]	+

OCA at 13:44, 16 November 2017

OCA — Thu, 16 Nov 2017 13:44:59 GMT

←Older revision		Revision as of 13:44, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 4rh2 is ON HOLD until Paper Publication~~	+	==Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid==
-		+	<StructureSection load='4rh2' size='340' side='right' caption='[[4rh2]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~Authors: Ferraroni, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rh2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RH2 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FC9:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-[({[1-(4-SULFAMOYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}CARBAMOTHIOYL)AMINO]BENZOIC+ACID'>FC9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rh2 OCA], [http://pdbe.org/4rh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rh2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rh2 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
	[[Category: Ferraroni, M]]		[[Category: Ferraroni, M]]
		+	[[Category: Lyase]]

OCA at 16:52, 24 December 2014

OCA — Wed, 24 Dec 2014 16:52:11 GMT

←Older revision		Revision as of 16:52, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid		Description: Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid
		+	[[Category: Unreleased Structures]]
		+	[[Category: Ferraroni, M]]

OCA: Protected "4rh2" [edit=sysop:move=sysop]

OCA — Wed, 08 Oct 2014 06:35:04 GMT

Protected "4rh2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4rh2 is ON HOLD until Paper Publication Authors: Ferraroni, M. Description: Crystal structure of human carbonic anhydrase II in complex with 2-(6-h...

OCA — Wed, 08 Oct 2014 06:35:02 GMT

New page: '''Unreleased structure''' The entry 4rh2 is ON HOLD until Paper Publication Authors: Ferraroni, M. Description: Crystal structure of human carbonic anhydrase II in complex with 2-(6-h...

New page

'''Unreleased structure'''

The entry 4rh2 is ON HOLD until Paper Publication

Authors: Ferraroni, M.

Description: Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid