4rhx - Revision history

OCA at 12:52, 1 March 2024

OCA — Fri, 01 Mar 2024 12:52:38 GMT

←Older revision		Revision as of 12:52, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.0322Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [https://pdbe.org/4rhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [https://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [https://pdbe.org/4rhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [https://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref>		[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human tuberculosis is a chronic infectious disease affecting millions of lives. Because of emerging resistance to current medications, new therapeutic drugs are needed. One potential new target is hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT), a key enzyme of the purine salvage pathway. Here, newly synthesized acyclic nucleoside phosphonates (ANPs) have been shown to be competitive inhibitors of MtHGPRT with Ki values as low as 0.69 muM. Prodrugs of these compounds arrest the growth of a virulent strain of M. tuberculosis with MIC50 values as low as 4.5 muM and possess low cytotoxicity in mammalian cells (CC50 values as high as >300 muM). In addition, the first crystal structures of MtHGPRT (2.03-2.76 A resolution) have been determined, three of these in complex with novel ANPs and one with GMP and pyrophosphate. These data provide a solid foundation for the further development of ANPs as selective inhibitors of MtHGPRT and as antituberculosis agents.
-
-	First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.,Eng WS, Hockova D, Spacek P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW J Med Chem. 2015 May 13. PMID:25915781<ref>PMID:25915781</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:57, 2 March 2023

OCA — Thu, 02 Mar 2023 06:57:28 GMT

←Older revision		Revision as of 06:57, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4rhx' size='340' side='right'caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4rhx' size='340' side='right'caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [~~http~~://pdbe.org/4rhx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [https://pdbe.org/4rhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [https://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eng~~, W S~~]]	+	[[Category: Mycobacterium tuberculosis H37Ra]]
-	[[Category: Guddat~~, L W~~]]	+	[[Category: Eng WS]]
-	[[Category: Hockova, D]]	+	[[Category: Guddat LW]]
-	[[Category: Keough~~, D T~~]]	+	[[Category: Hockova D]]
-	[[Category: Naesens~~, L M.J~~]]	+	[[Category: Keough DT]]
-	[[Category: Spacek, P]]	+	[[Category: Naesens LMJ]]
-	[[Category: West~~, N P~~]]	+	[[Category: Spacek P]]
-	[[Category: Woods, K]]	+	[[Category: West NP]]
-	~~[[Category: 6-oxopurine phosphoribosyltransferase]]~~	+	[[Category: Woods K]]
-	~~[[Category: Cytoplasmic]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 10:19, 1 May 2019

OCA — Wed, 01 May 2019 10:19:41 GMT

←Older revision		Revision as of 10:19, 1 May 2019
Line 1:		Line 1:

	==Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==		==Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==
-	<StructureSection load='4rhx' size='340' side='right' caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='4rhx' size='340' side='right'caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eng, W S]]		[[Category: Eng, W S]]
	[[Category: Guddat, L W]]		[[Category: Guddat, L W]]

OCA at 14:25, 29 March 2017

OCA — Wed, 29 Mar 2017 14:25:22 GMT

←Older revision		Revision as of 14:25, 29 March 2017
Line 1:		Line 1:
		+
	==Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==		==Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==
	<StructureSection load='4rhx' size='340' side='right' caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='4rhx' size='340' side='right' caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [http://www.ebi.ac.uk/pdbsum/4rhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [http://pdbe.org/4rhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [http://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:11, 20 May 2015

OCA — Wed, 20 May 2015 12:11:00 GMT

←Older revision		Revision as of 12:11, 20 May 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease==
		+	<StructureSection load='4rhx' size='340' side='right' caption='[[4rhx]], [[Resolution\|resolution]] 2.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [http://www.ebi.ac.uk/pdbsum/4rhx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human tuberculosis is a chronic infectious disease affecting millions of lives. Because of emerging resistance to current medications, new therapeutic drugs are needed. One potential new target is hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT), a key enzyme of the purine salvage pathway. Here, newly synthesized acyclic nucleoside phosphonates (ANPs) have been shown to be competitive inhibitors of MtHGPRT with Ki values as low as 0.69 muM. Prodrugs of these compounds arrest the growth of a virulent strain of M. tuberculosis with MIC50 values as low as 4.5 muM and possess low cytotoxicity in mammalian cells (CC50 values as high as >300 muM). In addition, the first crystal structures of MtHGPRT (2.03-2.76 A resolution) have been determined, three of these in complex with novel ANPs and one with GMP and pyrophosphate. These data provide a solid foundation for the further development of ANPs as selective inhibitors of MtHGPRT and as antituberculosis agents.

-	~~The entry 4rhx is ON HOLD until Paper Publication~~	+	First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.,Eng WS, Hockova D, Spacek P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW J Med Chem. 2015 May 13. PMID:25915781<ref>PMID:25915781</ref>

-	~~Authors: Eng~~, W.S.~~, Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Woods~~, K]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Eng, W S]]
		+	[[Category: Guddat, L W]]
	[[Category: Hockova, D]]		[[Category: Hockova, D]]
-	[[Category: ~~West~~, N.P]]	+	[[Category: Keough, D T]]
		+	[[Category: Naesens, L M.J]]
	[[Category: Spacek, P]]		[[Category: Spacek, P]]
-	[[Category: ~~Eng~~, ~~W.S~~]]	+	[[Category: West, N P]]
-	[[Category: ~~Naesens~~, ~~L.M.J~~]]	+	[[Category: Woods, K]]
-	[[Category: ~~Keough, D.T~~]]	+	[[Category: 6-oxopurine phosphoribosyltransferase]]
-	[[Category: ~~Guddat, L.W~~]]	+	[[Category: Cytoplasmic]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 16:54, 24 December 2014

OCA — Wed, 24 Dec 2014 16:54:02 GMT

←Older revision		Revision as of 16:54, 24 December 2014
Line 6:		Line 6:

	Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease		Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease
		+	[[Category: Unreleased Structures]]
		+	[[Category: Woods, K]]
		+	[[Category: Hockova, D]]
		+	[[Category: West, N.P]]
		+	[[Category: Spacek, P]]
		+	[[Category: Eng, W.S]]
		+	[[Category: Naesens, L.M.J]]
		+	[[Category: Keough, D.T]]
		+	[[Category: Guddat, L.W]]

OCA at 11:25, 19 November 2014

OCA — Wed, 19 Nov 2014 11:25:32 GMT

←Older revision		Revision as of 11:25, 19 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rhx is ON HOLD	+	The entry 4rhx is ON HOLD until Paper Publication

	Authors: Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.		Authors: Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.

	Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease		Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

OCA at 09:28, 20 October 2014

OCA — Mon, 20 Oct 2014 09:28:58 GMT

←Older revision		Revision as of 09:28, 20 October 2014
Line 3:		Line 3:
	The entry 4rhx is ON HOLD		The entry 4rhx is ON HOLD

-	Authors: Eng, W. S., Hockova, D., Spacek, P., West, N. P., Woods, K., Naesens, L. M. J., Keough, D. T., Guddat, L. W.	+	Authors: Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.

-	Description: ~~Crystal structures~~ of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease	+	Description: Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

OCA: Protected "4rhx" [edit=sysop:move=sysop]

OCA — Wed, 08 Oct 2014 06:36:17 GMT

Protected "4rhx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4rhx is ON HOLD Authors: Eng, W. S., Hockova, D., Spacek, P., West, N. P., Woods, K., Naesens, L. M. J., Keough, D. T., Guddat, L. W. Description: ...

OCA — Wed, 08 Oct 2014 06:36:16 GMT

New page: '''Unreleased structure''' The entry 4rhx is ON HOLD Authors: Eng, W. S., Hockova, D., Spacek, P., West, N. P., Woods, K., Naesens, L. M. J., Keough, D. T., Guddat, L. W. Description: ...

New page

'''Unreleased structure'''

The entry 4rhx is ON HOLD

Authors: Eng, W. S., Hockova, D., Spacek, P., West, N. P., Woods, K., Naesens, L. M. J., Keough, D. T., Guddat, L. W.

Description: Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease