4ris - Revision history

OCA at 06:58, 2 March 2023

OCA — Thu, 02 Mar 2023 06:58:43 GMT

←Older revision		Revision as of 06:58, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4ris' size='340' side='right'caption='[[4ris]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4ris' size='340' side='right'caption='[[4ris]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ris]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RIS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ris]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIS FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rir\|4rir]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [https://pdbe.org/4ris PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [https://www.ebi.ac.uk/pdbsum/4ris PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ris ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [~~http~~://pdbe.org/4ris PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ris PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ris ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q70966_9HIV1 Q70966_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alam~~, S M~~]]	+	[[Category: Alam SM]]
-	[[Category: Bonsignori, M]]	+	[[Category: Bonsignori M]]
-	~~[[Category: Connell, R J.O~~]]	+	[[Category: Dennison SM]]
-	[[Category: Dennison~~, S M~~]]	+	[[Category: Haynes BF]]
-	[[Category: Haynes~~, B F~~]]	+	[[Category: Hwang K-K]]
-	[[Category: Hwang, K K]]	+	[[Category: Jaeger FH]]
-	[[Category: Jaeger~~, F H~~]]	+	[[Category: Kaewkungwal J]]
-	[[Category: Kaewkungwal, J]]	+	[[Category: Kepler TB]]
-	[[Category: Kepler~~, T B~~]]	+	[[Category: Kim JH]]
-	[[Category: Kim~~, J H~~]]	+	[[Category: Liao H-X]]
-	[[Category: Liao, H X]]	+	[[Category: Michael NL]]
-	[[Category: Michael~~, N L~~]]	+	[[Category: Nicely NI]]
-	[[Category: Nicely~~, N I~~]]	+	[[Category: Nitayaphan S]]
-	[[Category: Nitayaphan, S]]	+	[[Category: O'Connell RJ]]
-	[[Category: Pitisuttithum, P]]	+	[[Category: Pitisuttithum P]]
-	[[Category: Rerks-Ngarm, S]]	+	[[Category: Rerks-Ngarm S]]
-	[[Category: Robb~~, M L~~]]	+	[[Category: Robb ML]]
-	[[Category: Wiehe, K]]	+	[[Category: Wiehe K]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Hiv-1 gp120 v2 region]]~~	+
-	~~[[Category: Igg fold]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 10:21, 1 May 2019

OCA — Wed, 01 May 2019 10:21:06 GMT

←Older revision		Revision as of 10:21, 1 May 2019
Line 1:		Line 1:
		+
	==Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk==		==Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk==
-	<StructureSection load='4ris' size='340' side='right' caption='[[4ris]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4ris' size='340' side='right'caption='[[4ris]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ris]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ris]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rir\|4rir]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rir\|4rir]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [http://www.ebi.ac.uk/pdbsum/4ris PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [http://pdbe.org/4ris PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [http://www.ebi.ac.uk/pdbsum/4ris PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ris ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ris" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Alam, S M]]		[[Category: Alam, S M]]
	[[Category: Bonsignori, M]]		[[Category: Bonsignori, M]]

OCA at 06:40, 2 September 2015

OCA — Wed, 02 Sep 2015 06:40:57 GMT

←Older revision		Revision as of 06:40, 2 September 2015
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [http://www.ebi.ac.uk/pdbsum/4ris PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [http://www.ebi.ac.uk/pdbsum/4ris PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure. CH58 neutralizes HIV-1 CRF_01 AE strain 92TH023 and mediates ADCC against CD4 + T cell targets infected with CRF_01 AE tier 2 virus. CH58 and other antibodies that bind to a gp120 V2 epitope have a second light chain complementarity determining region (LCDR2) bearing a glutamic acid, aspartic acid (ED) motif involved in forming salt bridges with polar, basic side amino acid side chains in V2. In an effort to learn how V2 responses develop, we determined the crystal structures of the CH58-UA antibody unliganded and bound to V2 peptide. The structures showed an LCDR2 structurally pre-conformed from germline to interact with V2 residue Lys169. LCDR3 was subject to conformational selection through the affinity maturation process. Kinetic analyses demonstrate that only a few contacts were responsible for a 2000-fold increase in KD through maturation, and this effect was predominantly due to an improvement in off-rate. This study shows that preconformation and preconfiguration can work in concert to produce antibodies with desired immunogenic properties.
		+
		+	Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.,Nicely NI, Wiehe K, Kepler TB, Jaeger FH, Dennison SM, Rerks-Ngarm S, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Robb ML, O'Connell RJ, Michael NL, Kim JH, Liao HX, Munir Alam S, Hwang KK, Bonsignori M, Haynes BF EBioMedicine. 2015 Jun 20;2(7):713-22. doi: 10.1016/j.ebiom.2015.06.016., eCollection 2015 Jul. PMID:26288844<ref>PMID:26288844</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:46, 12 August 2015

OCA — Wed, 12 Aug 2015 14:46:31 GMT

←Older revision		Revision as of 14:46, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk==
-		+	<StructureSection load='4ris' size='340' side='right' caption='[[4ris]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 4ris is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ris]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIS FirstGlance]. <br>
-	~~Authors~~: ~~Nicely, N~~.I.~~, Wiehe, K~~.~~, Kepler, T~~.B.~~, Jaeger, F~~.H.~~, Dennison, S~~.M.~~, Liao, H~~.-X.~~, Alam, S~~.M., ~~Hwang, K~~.-K.~~, Bonsignori, M~~.~~, Rerks~~-~~Ngarm~~, S.~~, Nitayaphan, S~~.~~, Pitisuttithum, P~~., ~~Kaewkungwal, J~~.~~, Robb, M~~.L., O'Connell, R.J., ~~Michael, N.L., Kim, J.H.,~~ Haynes, B.F.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rir\|4rir]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ris FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ris OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ris RCSB], [http://www.ebi.ac.uk/pdbsum/4ris PDBsum]</span></td></tr>
-	Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	__TOC__
-	[[Category: ~~Kim~~, J.H]]	+	</StructureSection>
		+	[[Category: Alam, S M]]
		+	[[Category: Bonsignori, M]]
		+	[[Category: Connell, R J.O]]
		+	[[Category: Dennison, S M]]
		+	[[Category: Haynes, B F]]
		+	[[Category: Hwang, K K]]
		+	[[Category: Jaeger, F H]]
	[[Category: Kaewkungwal, J]]		[[Category: Kaewkungwal, J]]
		+	[[Category: Kepler, T B]]
		+	[[Category: Kim, J H]]
		+	[[Category: Liao, H X]]
		+	[[Category: Michael, N L]]
		+	[[Category: Nicely, N I]]
		+	[[Category: Nitayaphan, S]]
	[[Category: Pitisuttithum, P]]		[[Category: Pitisuttithum, P]]
-	[[Category: Haynes, B.F]]
	[[Category: Rerks-Ngarm, S]]		[[Category: Rerks-Ngarm, S]]
-	[[Category: ~~Nitayaphan, S]]~~	+	[[Category: Robb, M L]]
-	~~[[Category: Bonsignori~~, M]]	+
-	~~[[Category: Jaeger, F.H~~]]	+
	[[Category: Wiehe, K]]		[[Category: Wiehe, K]]
-	[[Category: ~~Michael, N.L~~]]	+	[[Category: Antibody]]
-	[[Category: ~~O'Connell, R.J]]~~	+	[[Category: Hiv-1 gp120 v2 region]]
-	~~[[Category: Kepler, T.B]]~~	+	[[Category: Igg fold]]
-	~~[[Category: Hwang, K.~~-K]]	+	[[Category: Immune system]]
-	[[Category: ~~Dennison, S.M]]~~	+
-	~~[[Category: Robb, M.L]]~~	+
-	~~[[Category: Alam, S.M]]~~	+
-	~~[[Category: Liao, H.-X~~]]	+
-	[[Category: ~~Nicely, N.I~~]]	+

OCA at 10:36, 14 January 2015

OCA — Wed, 14 Jan 2015 10:36:45 GMT

←Older revision		Revision as of 10:36, 14 January 2015
Line 3:		Line 3:
	The entry 4ris is ON HOLD until Paper Publication		The entry 4ris is ON HOLD until Paper Publication

-	Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F.	+	Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H.-X., Alam, S.M., Hwang, K.-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F.

	Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk		Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk
Line 17:		Line 17:
	[[Category: Wiehe, K]]		[[Category: Wiehe, K]]
	[[Category: Michael, N.L]]		[[Category: Michael, N.L]]
-	[[Category: Liao, H-X]]
	[[Category: O'Connell, R.J]]		[[Category: O'Connell, R.J]]
	[[Category: Kepler, T.B]]		[[Category: Kepler, T.B]]
-	[[Category: Hwang, K-K]]	+	[[Category: Hwang, K.-K]]
	[[Category: Dennison, S.M]]		[[Category: Dennison, S.M]]
	[[Category: Robb, M.L]]		[[Category: Robb, M.L]]
	[[Category: Alam, S.M]]		[[Category: Alam, S.M]]
		+	[[Category: Liao, H.-X]]
	[[Category: Nicely, N.I]]		[[Category: Nicely, N.I]]

OCA at 16:56, 24 December 2014

OCA — Wed, 24 Dec 2014 16:56:36 GMT

←Older revision		Revision as of 16:56, 24 December 2014
Line 6:		Line 6:

	Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk		Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk
		+	[[Category: Unreleased Structures]]
		+	[[Category: Kim, J.H]]
		+	[[Category: Kaewkungwal, J]]
		+	[[Category: Pitisuttithum, P]]
		+	[[Category: Haynes, B.F]]
		+	[[Category: Rerks-Ngarm, S]]
		+	[[Category: Nitayaphan, S]]
		+	[[Category: Bonsignori, M]]
		+	[[Category: Jaeger, F.H]]
		+	[[Category: Wiehe, K]]
		+	[[Category: Michael, N.L]]
		+	[[Category: Liao, H-X]]
		+	[[Category: O'Connell, R.J]]
		+	[[Category: Kepler, T.B]]
		+	[[Category: Hwang, K-K]]
		+	[[Category: Dennison, S.M]]
		+	[[Category: Robb, M.L]]
		+	[[Category: Alam, S.M]]
		+	[[Category: Nicely, N.I]]

OCA at 07:38, 5 November 2014

OCA — Wed, 05 Nov 2014 07:38:26 GMT

←Older revision		Revision as of 07:38, 5 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ris is ON HOLD	+	The entry 4ris is ON HOLD until Paper Publication

	Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F.		Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F.

	Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk		Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk

OCA: Protected "4ris" [edit=sysop:move=sysop]

OCA — Mon, 20 Oct 2014 09:30:33 GMT

Protected "4ris" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:30, 20 October 2014

OCA: New page: '''Unreleased structure''' The entry 4ris is ON HOLD Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., R...

OCA — Mon, 20 Oct 2014 09:30:31 GMT

New page: '''Unreleased structure''' The entry 4ris is ON HOLD Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., R...

New page

'''Unreleased structure'''

The entry 4ris is ON HOLD

Authors: Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H-X., Alam, S.M., Hwang, K-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F.

Description: Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk