4rlz - Revision history

OCA at 15:15, 8 November 2023

OCA — Wed, 08 Nov 2023 15:15:45 GMT

←Older revision		Revision as of 15:15, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.19Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [https://pdbe.org/4rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [https://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [https://pdbe.org/4rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [https://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:03, 2 March 2023

OCA — Thu, 02 Mar 2023 07:03:05 GMT

←Older revision		Revision as of 07:03, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4rlz' size='340' side='right'caption='[[4rlz]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='4rlz' size='340' side='right'caption='[[4rlz]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus_nlv~~/~~if1998~~/2003/~~iraq~~ Norovirus ~~nlv~~/~~if1998~~/2003/~~iraq~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [https://pdbe.org/4rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [https://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [~~http~~://pdbe.org/4rlz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6B7R3_9CALI Q6B7R3_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4rlz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rlz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Norovirus ~~nlv~~/~~if1998~~/2003/~~iraq~~]]	+	[[Category: Norovirus NLV/IF1998/2003/Iraq]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Jiang, X]]	+	[[Category: Jiang X]]
-	[[Category: Li, X]]	+	[[Category: Li X]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	[[Category: Rao, Z]]	+	[[Category: Rao Z]]
-	[[Category: Tan, M]]	+	[[Category: Tan M]]
-	[[Category: Xia, M]]	+	[[Category: Xia M]]
-	~~[[Category: Hbga]]~~	+
-	~~[[Category: Mixed alpha/beta structure]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus caspid~~]]	+

OCA at 09:49, 1 May 2019

OCA — Wed, 01 May 2019 09:49:46 GMT

←Older revision		Revision as of 09:49, 1 May 2019
Line 1:		Line 1:
		+
	==Crystal structure of Norovirus OIF P domain==		==Crystal structure of Norovirus OIF P domain==
-	<StructureSection load='4rlz' size='340' side='right' caption='[[4rlz]], [[Resolution\|resolution]] 1.19Å' scene=''>	+	<StructureSection load='4rlz' size='340' side='right'caption='[[4rlz]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_nlv/if1998/2003/iraq Norovirus nlv/if1998/2003/iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://pdbe.org/4rlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://pdbe.org/4rlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Norovirus nlv/if1998/2003/iraq]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Jiang, X]]		[[Category: Jiang, X]]

OCA at 23:48, 21 October 2015

OCA — Wed, 21 Oct 2015 23:48:51 GMT

←Older revision		Revision as of 23:48, 21 October 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://pdbe.org/4rlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Norovirus (NoV) causes epidemic acute gastroenteritis in humans, whereby histo-blood group antigens (HBGAs) play an important role in host susceptibility. Each of the two major genogroups (GI and GII) of human NoVs recognizes a unique set of HBGAs through a distinct binding interface that is conserved within a genogroup, indicating a distinct evolutionary path for each genogroup. Here, we characterize a Lewis a (Lea) antigen binding strain (OIF virus) in the GII.21 genotype that does not share the conserved GII binding interface, revealing a new evolution lineage with a distinct HBGA binding interface. Sequence alignment showed that the major residues contributing to the new HBGA binding interface are conserved among most members of the GII.21, as well as a closely related GII.13 genotype. In addition, we found that glycerol inhibits OIF binding to HBGAs, potentially allowing production of cheap antivirals against human NoVs. Taken together, our results reveal a new evolutionary lineage of NoVs selected by HBGAs, a finding that is important for understanding the diversity and widespread nature of NoVs.
		+
		+	A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface.,Liu W, Chen Y, Jiang X, Xia M, Yang Y, Tan M, Li X, Rao Z PLoS Pathog. 2015 Jul 6;11(7):e1005025. doi: 10.1371/journal.ppat.1005025., eCollection 2015 Jul. PMID:26147716<ref>PMID:26147716</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4rlz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:59, 24 June 2015

OCA — Wed, 24 Jun 2015 12:59:15 GMT

←Older revision		Revision as of 12:59, 24 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Norovirus OIF P domain==
-		+	<StructureSection load='4rlz' size='340' side='right' caption='[[4rlz]], [[Resolution\|resolution]] 1.19Å' scene=''>
-	~~The entry~~ 4rlz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
-	~~Authors~~: ~~Liu, W~~.~~, Chen, Y~~.~~, Tan, M~~.~~, Xia, M~~., ~~Li, X~~., ~~Jiang, X~~., ~~Rao, Z~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rm0\|4rm0]]</td></tr>
-	~~Description~~: ~~Crystal structure of Norovirus OIF P domain~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Xia~~, M]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Y]]
		+	[[Category: Jiang, X]]
		+	[[Category: Li, X]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
	[[Category: Rao, Z]]		[[Category: Rao, Z]]
	[[Category: Tan, M]]		[[Category: Tan, M]]
-	[[Category: ~~Chen~~, Y]]	+	[[Category: Xia, M]]
-	[[Category: ~~Li, X~~]]	+	[[Category: Hbga]]
-	[[Category: ~~Jiang, X~~]]	+	[[Category: Mixed alpha/beta structure]]
		+	[[Category: Receptor binding]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus caspid]]

OCA at 17:01, 24 December 2014

OCA — Wed, 24 Dec 2014 17:01:25 GMT

←Older revision		Revision as of 17:01, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of Norovirus OIF P domain		Description: Crystal structure of Norovirus OIF P domain
		+	[[Category: Unreleased Structures]]
		+	[[Category: Xia, M]]
		+	[[Category: Liu, W]]
		+	[[Category: Rao, Z]]
		+	[[Category: Tan, M]]
		+	[[Category: Chen, Y]]
		+	[[Category: Li, X]]
		+	[[Category: Jiang, X]]

OCA at 08:16, 3 December 2014

OCA — Wed, 03 Dec 2014 08:16:49 GMT

←Older revision		Revision as of 08:16, 3 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rlz is ON HOLD	+	The entry 4rlz is ON HOLD until Paper Publication

	Authors: Liu, W., Chen, Y., Tan, M., Xia, M., Li, X., Jiang, X., Rao, Z.		Authors: Liu, W., Chen, Y., Tan, M., Xia, M., Li, X., Jiang, X., Rao, Z.

	Description: Crystal structure of Norovirus OIF P domain		Description: Crystal structure of Norovirus OIF P domain

OCA: Protected "4rlz" [edit=sysop:move=sysop]

OCA — Wed, 29 Oct 2014 10:08:59 GMT

Protected "4rlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:08, 29 October 2014

OCA: New page: '''Unreleased structure''' The entry 4rlz is ON HOLD Authors: Liu, W., Chen, Y., Tan, M., Xia, M., Li, X., Jiang, X., Rao, Z. Description: Crystal structure of Norovirus OIF P domain

OCA — Wed, 29 Oct 2014 10:08:58 GMT

New page: '''Unreleased structure''' The entry 4rlz is ON HOLD Authors: Liu, W., Chen, Y., Tan, M., Xia, M., Li, X., Jiang, X., Rao, Z. Description: Crystal structure of Norovirus OIF P domain

New page

'''Unreleased structure'''

The entry 4rlz is ON HOLD

Authors: Liu, W., Chen, Y., Tan, M., Xia, M., Li, X., Jiang, X., Rao, Z.

Description: Crystal structure of Norovirus OIF P domain