4rqn - Revision history

OCA at 17:54, 20 September 2023

OCA — Wed, 20 Sep 2023 17:54:04 GMT

←Older revision		Revision as of 17:54, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [https://pdbe.org/4rqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [https://www.ebi.ac.uk/pdbsum/4rqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [https://pdbe.org/4rqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [https://www.ebi.ac.uk/pdbsum/4rqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rqn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:24, 8 March 2023

OCA — Wed, 08 Mar 2023 08:24:38 GMT

←Older revision		Revision as of 08:24, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='4rqn' size='340' side='right'caption='[[4rqn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rqn' size='340' side='right'caption='[[4rqn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rqm\|4rqm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [https://pdbe.org/4rqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [https://www.ebi.ac.uk/pdbsum/4rqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rqn ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BICC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [~~http~~://pdbe.org/4rqn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rqn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rqn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Autosomal dominant polycystic kidney disease. Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN] Autosomal dominant polycystic kidney disease. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>	+	[https://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bowie~~, J U~~]]	+	[[Category: Bowie JU]]
-	[[Category: Cascio, D]]	+	[[Category: Cascio D]]
-	[[Category: Leettola~~, C N]]~~	+	[[Category: Leettola CN]]
-	~~[[Category: P-body]]~~	+
-	~~[[Category: Polymerization]]~~	+
-	~~[[Category: Polymerization domain]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein interaction domain]]~~	+
-	~~[[Category: Sam domain~~]]	+

OCA at 07:23, 23 October 2019

OCA — Wed, 23 Oct 2019 07:23:49 GMT

←Older revision		Revision as of 07:23, 23 October 2019
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>		[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Head-to-tail polymers of sterile alpha motifs (SAM) can scaffold large macromolecular complexes. Several SAM-domain proteins that bind each other are mutated in patients with cystic kidneys or laterality defects, including the Ankyrin (ANK) and SAM domain-containing proteins ANKS6 and ANKS3, and the RNA-binding protein Bicc1. To address how their interactions are regulated, we first determined a high-resolution crystal structure of a Bicc1-SAM polymer, revealing a canonical SAM polymer with a high degree of flexibility in the subunit interface orientations. We further mapped interactions between full-length and distinct domains of Bicc1, ANKS3, and ANKS6. Neither ANKS3 nor ANKS6 alone formed macroscopic homopolymers in vivo. However, ANKS3 recruited ANKS6 to Bicc1, and the three proteins together cooperatively generated giant macromolecular complexes. Thus, the giant assemblies are shaped by SAM domains, their flanking sequences, and SAM-independent protein-protein and protein-mRNA interactions.
		+
		+	Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.,Rothe B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB Structure. 2018 Feb 6;26(2):209-224.e6. doi: 10.1016/j.str.2017.12.002. Epub 2017, Dec 28. PMID:29290488<ref>PMID:29290488</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4rqn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 1 May 2019

OCA — Wed, 01 May 2019 10:22:57 GMT

←Older revision		Revision as of 10:22, 1 May 2019
Line 1:		Line 1:
		+
	==Crystal structure of the native BICC1 SAM Domain R924E mutant==		==Crystal structure of the native BICC1 SAM Domain R924E mutant==
-	<StructureSection load='4rqn' size='340' side='right' caption='[[4rqn]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4rqn' size='340' side='right'caption='[[4rqn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rqm\|4rqm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rqm\|4rqm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [http://pdbe.org/4rqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [http://www.ebi.ac.uk/pdbsum/4rqn PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BICC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [http://pdbe.org/4rqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [http://www.ebi.ac.uk/pdbsum/4rqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rqn ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 02:25, 28 January 2016

OCA — Thu, 28 Jan 2016 02:25:20 GMT

←Older revision		Revision as of 02:25, 28 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the native BICC1 SAM Domain R924E mutant==
-		+	<StructureSection load='4rqn' size='340' side='right' caption='[[4rqn]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~The entry~~ 4rqn is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rqn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RQN FirstGlance]. <br>
-	~~Authors~~: ~~Leettola~~, C.N., ~~Cascio, D~~., ~~Bowie~~, J.U.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rqm\|4rqm]]</td></tr>
-	~~Description: Crystal structure of the native BICC1 SAM Domain R924E mutant~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rqn OCA], [http://pdbe.org/4rqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rqn RCSB], [http://www.ebi.ac.uk/pdbsum/4rqn PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Leettola, C~~.N]]	+	== Disease ==
-	[[Category: Bowie, J.U]]	+	[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Autosomal dominant polycystic kidney disease. Disease susceptibility is associated with variations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BICC1_HUMAN BICC1_HUMAN]] Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.<ref>PMID:21922595</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bowie, J U]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
		+	[[Category: Leettola, C N]]
		+	[[Category: P-body]]
		+	[[Category: Polymerization]]
		+	[[Category: Polymerization domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein interaction domain]]
		+	[[Category: Sam domain]]

OCA at 12:04, 31 December 2014

OCA — Wed, 31 Dec 2014 12:04:21 GMT

←Older revision		Revision as of 12:04, 31 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rqn is ON HOLD	+	The entry 4rqn is ON HOLD until Paper Publication

	Authors: Leettola, C.N., Cascio, D., Bowie, J.U.		Authors: Leettola, C.N., Cascio, D., Bowie, J.U.

OCA at 17:13, 24 December 2014

OCA — Wed, 24 Dec 2014 17:13:58 GMT

←Older revision		Revision as of 17:13, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of the native BICC1 SAM Domain R924E mutant		Description: Crystal structure of the native BICC1 SAM Domain R924E mutant
		+	[[Category: Unreleased Structures]]
		+	[[Category: Leettola, C.N]]
		+	[[Category: Bowie, J.U]]
		+	[[Category: Cascio, D]]

OCA: Protected "4rqn" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:30:31 GMT

Protected "4rqn" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:30, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4rqn is ON HOLD Authors: Leettola, C.N., Cascio, D., Bowie, J.U. Description: Crystal structure of the native BICC1 SAM Domain R924E mutant

OCA — Wed, 19 Nov 2014 11:30:30 GMT

New page: '''Unreleased structure''' The entry 4rqn is ON HOLD Authors: Leettola, C.N., Cascio, D., Bowie, J.U. Description: Crystal structure of the native BICC1 SAM Domain R924E mutant

New page

'''Unreleased structure'''

The entry 4rqn is ON HOLD

Authors: Leettola, C.N., Cascio, D., Bowie, J.U.

Description: Crystal structure of the native BICC1 SAM Domain R924E mutant