4rrz - Revision history

OCA at 17:54, 20 September 2023

OCA — Wed, 20 Sep 2023 17:54:23 GMT

←Older revision		Revision as of 17:54, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.569Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [https://pdbe.org/4rrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [https://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [https://pdbe.org/4rrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [https://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:26, 8 March 2023

OCA — Wed, 08 Mar 2023 08:26:27 GMT

←Older revision		Revision as of 08:26, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='4rrz' size='340' side='right'caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>		<StructureSection load='4rrz' size='340' side='right'caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [https://pdbe.org/4rrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [https://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [~~http~~://pdbe.org/4rrz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>	+	[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Cyclooxygenase\|Cyclooxygenase]]	+	*[[Cyclooxygenase 3D structures\|Cyclooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Prostaglandin-endoperoxide synthase~~]]	+	[[Category: Banerjee S]]
-	[[Category: Banerjee, S]]	+	[[Category: Blobaum AL]]
-	[[Category: Blobaum~~, A L~~]]	+	[[Category: Marnett LJ]]
-	[[Category: Marnett~~, L J~~]]	+	[[Category: Xu S]]
-	[[Category: Xu, S]]	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nsaid]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein-drug complex~~]]	+

OCA at 09:34, 1 May 2019

OCA — Wed, 01 May 2019 09:34:24 GMT

←Older revision		Revision as of 09:34, 1 May 2019
Line 1:		Line 1:

	==Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib==		==Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib==
-	<StructureSection load='4rrz' size='340' side='right' caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>	+	<StructureSection load='4rrz' size='340' side='right'caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [http://pdbe.org/4rrz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [http://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [http://pdbe.org/4rrz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [http://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4rrz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rrz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase\|Cyclooxygenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Banerjee, S]]		[[Category: Banerjee, S]]

OCA at 01:44, 10 March 2017

OCA — Fri, 10 Mar 2017 01:44:13 GMT

←Older revision		Revision as of 01:44, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib==		==Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib==
	<StructureSection load='4rrz' size='340' side='right' caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>		<StructureSection load='4rrz' size='340' side='right' caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [http://www.ebi.ac.uk/pdbsum/4rrz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [http://pdbe.org/4rrz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [http://www.ebi.ac.uk/pdbsum/4rrz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rrz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 6 May 2015

OCA — Wed, 06 May 2015 07:12:15 GMT

←Older revision		Revision as of 07:12, 6 May 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>		[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid (AA) to prostaglandin (PG)G2. The inhibitory activity of rapid, reversible COX inhibitors (ibuprofen, naproxen, mefenamic acid, and lumiracoxib) demonstrated a significant increase in potency and time-dependence of inhibition against double tryptophan mCOX-2 mutants at the 89/90 and 89/119 positions. In contrast, the slow, time-dependent COX inhibitors (diclofenac, indomethacin, and flurbiprofen) were unaffected by those mutations. Further mutagenesis studies suggested that mutation at position 89 was principally responsible for the changes in inhibitory potency of rapid, reversible inhibitors, while mutation at position 90 may exert some effect on the potency of COX-2-selective diarylheterocycle inhibitors; no effect was observed with mutation at position 119. Several crystal structures with or without NSAIDs indicated that placement of a bulky residue at position 89 caused a closure of a gap at the lobby, and alteration of histidine to tryptophan at position 90 changed the electrostatic profile of the side-pocket of COX-2. Thus, these two residues, especially Val-89 at the lobby region, are crucial for the entrance and exit of some NSAIDs from the COX active site.
		+
		+	Action at a Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow, Tight Binders of Cyclooxygenase-2.,Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ J Biol Chem. 2015 Mar 30. pii: jbc.M114.635987. PMID:25825493<ref>PMID:25825493</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:14, 8 April 2015

OCA — Wed, 08 Apr 2015 11:14:54 GMT

←Older revision		Revision as of 11:14, 8 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib==
-		+	<StructureSection load='4rrz' size='340' side='right' caption='[[4rrz]], [[Resolution\|resolution]] 2.57Å' scene=''>
-	~~The entry~~ 4rrz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rrz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRZ FirstGlance]. <br>
-	~~Authors~~: Xu, S., ~~Blobaum~~, A.L., ~~Banerjee, S~~.~~, Marnett, L~~.J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUR:{2-[(2-CHLORO-6-FLUOROPHENYL)AMINO]-5-METHYLPHENYL}ACETIC+ACID'>LUR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rrw\|4rrw]], [[4rrx\|4rrx]], [[4rry\|4rry]], [[4rs0\|4rs0]]</td></tr>
-	~~Description~~: ~~Crystal Structure of Apo Murine H90W Cyclooxygenase~~-~~2 Complexed with Lumiracoxib~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rrz RCSB], [http://www.ebi.ac.uk/pdbsum/4rrz PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Blobaum, A~~.L]]	+	</table>
-	[[Category: ~~Xu, S~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Banerjee, S]]		[[Category: Banerjee, S]]
-	[[Category: Marnett, L.J]]	+	[[Category: Blobaum, A L]]
		+	[[Category: Marnett, L J]]
		+	[[Category: Xu, S]]
		+	[[Category: Glycosylation]]
		+	[[Category: Membrane]]
		+	[[Category: Nsaid]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein-drug complex]]

OCA at 17:16, 24 December 2014

OCA — Wed, 24 Dec 2014 17:16:47 GMT

←Older revision		Revision as of 17:16, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib		Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib
		+	[[Category: Unreleased Structures]]
		+	[[Category: Blobaum, A.L]]
		+	[[Category: Xu, S]]
		+	[[Category: Banerjee, S]]
		+	[[Category: Marnett, L.J]]

OCA at 06:45, 26 November 2014

OCA — Wed, 26 Nov 2014 06:45:47 GMT

←Older revision		Revision as of 06:45, 26 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rrz is ON HOLD	+	The entry 4rrz is ON HOLD until Paper Publication

	Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.		Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.

	Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib		Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib

OCA: Protected "4rrz" [edit=sysop:move=sysop]

OCA — Wed, 19 Nov 2014 11:32:27 GMT

Protected "4rrz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:32, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 4rrz is ON HOLD Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J. Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Comp...

OCA — Wed, 19 Nov 2014 11:32:25 GMT

New page: '''Unreleased structure''' The entry 4rrz is ON HOLD Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J. Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Comp...

New page

'''Unreleased structure'''

The entry 4rrz is ON HOLD

Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.

Description: Crystal Structure of Apo Murine H90W Cyclooxygenase-2 Complexed with Lumiracoxib