4rug - Revision history

OCA at 12:55, 1 March 2024

OCA — Fri, 01 Mar 2024 12:55:46 GMT

←Older revision		Revision as of 12:55, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [https://pdbe.org/4rug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [https://www.ebi.ac.uk/pdbsum/4rug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rug ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [https://pdbe.org/4rug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [https://www.ebi.ac.uk/pdbsum/4rug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rug ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 11:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>		[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	srGAP proteins regulate cell migration and morphogenesis by shaping the structure and dynamics of the cytoskeleton and membranes. First discovered as intracellular effectors for the Robo1 axon-guidance receptor, srGAPs were later identified as interacting with several other nuclear and cytoplasmic proteins. In all these cases, the srGAP SH3 domain mediates protein-protein interactions by recognizing a short proline-rich segment on the cognate-binding partner. However, as interactions between the isolated SH3 domain and a selected set of ligands show weak affinity and low specificity, it is not clear how srGAPs are precisely recruited to their signaling sites. Here, we report a two-component molecular mechanism that regulates ligand binding to srGAP2 by on the one hand dramatically tightening their association and on the other, moderately autoinhibiting and restricting binding. Our results allow the design of point mutations for better probing of srGAP2 activities, and may facilitate the identification of new srGAP2 ligands.
-
-	The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.,Guez-Haddad J, Sporny M, Sasson Y, Gevorkyan-Airapetov L, Lahav-Mankovski N, Margulies D, Radzimanowski J, Opatowsky Y Structure. 2015 Nov 3;23(11):1989-2000. doi: 10.1016/j.str.2015.08.009. Epub 2015, Sep 10. PMID:26365803<ref>PMID:26365803</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4rug" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:28, 8 March 2023

OCA — Wed, 08 Mar 2023 08:28:36 GMT

←Older revision		Revision as of 08:28, 8 March 2023
Line 1:		Line 1:

	==Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment==		==Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment==
-	<StructureSection load='4rug' size='340' side='right' caption='[[4rug]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='4rug' size='340' side='right'caption='[[4rug]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUG FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rtt\|4rtt]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [https://pdbe.org/4rug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [https://www.ebi.ac.uk/pdbsum/4rug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rug ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [~~http~~://pdbe.org/4rug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rug ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).	+	[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>	+	[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4rug" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rug" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase activating protein 3D structures\|Rho GTPase activating protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Guez-Hadad, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Opatowsky, Y~~]]	+	[[Category: Guez-Hadad J]]
-	[[Category: ~~Ligand binding]]~~	+	[[Category: Opatowsky Y]]
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Plasma membrane]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Robo1]]~~	+
-	~~[[Category: Sh3]]~~	+
-	~~[[Category: Srgap2~~]]	+

OCA at 09:10, 22 November 2017

OCA — Wed, 22 Nov 2017 09:10:18 GMT

←Older revision		Revision as of 09:10, 22 November 2017
Line 1:		Line 1:
		+
	==Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment==		==Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment==
	<StructureSection load='4rug' size='340' side='right' caption='[[4rug]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='4rug' size='340' side='right' caption='[[4rug]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rtt\|4rtt]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rtt\|4rtt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [http://pdbe.org/4rug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [http://www.ebi.ac.uk/pdbsum/4rug PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [http://pdbe.org/4rug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [http://www.ebi.ac.uk/pdbsum/4rug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rug ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Guez-Hadad, J]]		[[Category: Guez-Hadad, J]]
	[[Category: Opatowsky, Y]]		[[Category: Opatowsky, Y]]

OCA at 18:48, 30 November 2015

OCA — Mon, 30 Nov 2015 18:48:54 GMT

←Older revision		Revision as of 18:48, 30 November 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment==
		+	<StructureSection load='4rug' size='340' side='right' caption='[[4rug]], [[Resolution\|resolution]] 1.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4rug]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUG FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4rtt\|4rtt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rug OCA], [http://pdbe.org/4rug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rug RCSB], [http://www.ebi.ac.uk/pdbsum/4rug PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	srGAP proteins regulate cell migration and morphogenesis by shaping the structure and dynamics of the cytoskeleton and membranes. First discovered as intracellular effectors for the Robo1 axon-guidance receptor, srGAPs were later identified as interacting with several other nuclear and cytoplasmic proteins. In all these cases, the srGAP SH3 domain mediates protein-protein interactions by recognizing a short proline-rich segment on the cognate-binding partner. However, as interactions between the isolated SH3 domain and a selected set of ligands show weak affinity and low specificity, it is not clear how srGAPs are precisely recruited to their signaling sites. Here, we report a two-component molecular mechanism that regulates ligand binding to srGAP2 by on the one hand dramatically tightening their association and on the other, moderately autoinhibiting and restricting binding. Our results allow the design of point mutations for better probing of srGAP2 activities, and may facilitate the identification of new srGAP2 ligands.

-	The ~~entry 4rug is ON HOLD~~	+	The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.,Guez-Haddad J, Sporny M, Sasson Y, Gevorkyan-Airapetov L, Lahav-Mankovski N, Margulies D, Radzimanowski J, Opatowsky Y Structure. 2015 Nov 3;23(11):1989-2000. doi: 10.1016/j.str.2015.08.009. Epub 2015, Sep 10. PMID:26365803<ref>PMID:26365803</ref>

-	~~Authors: Opatowsky~~, Y.~~, Guez-Hadad, J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 4rug" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guez-Hadad, J]]
	[[Category: Opatowsky, Y]]		[[Category: Opatowsky, Y]]
-	[[Category: ~~Guez-Hadad, J~~]]	+	[[Category: Ligand binding]]
		+	[[Category: Nuclear]]
		+	[[Category: Plasma membrane]]
		+	[[Category: Protein binding]]
		+	[[Category: Robo1]]
		+	[[Category: Sh3]]
		+	[[Category: Srgap2]]

OCA at 13:25, 28 January 2015

OCA — Wed, 28 Jan 2015 13:25:43 GMT

←Older revision		Revision as of 13:25, 28 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rug is ON HOLD ~~until Paper Publication~~	+	The entry 4rug is ON HOLD

	Authors: Opatowsky, Y., Guez-Hadad, J.		Authors: Opatowsky, Y., Guez-Hadad, J.

OCA at 13:40, 7 January 2015

OCA — Wed, 07 Jan 2015 13:40:58 GMT

←Older revision		Revision as of 13:40, 7 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rug is ON HOLD	+	The entry 4rug is ON HOLD until Paper Publication

	Authors: Opatowsky, Y., Guez-Hadad, J.		Authors: Opatowsky, Y., Guez-Hadad, J.

OCA at 17:22, 24 December 2014

OCA — Wed, 24 Dec 2014 17:22:39 GMT

←Older revision		Revision as of 17:22, 24 December 2014
Line 5:		Line 5:
	Authors: Opatowsky, Y., Guez-Hadad, J.		Authors: Opatowsky, Y., Guez-Hadad, J.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Opatowsky, Y]]
		+	[[Category: Guez-Hadad, J]]

OCA: Protected "4rug" [edit=sysop:move=sysop]

OCA — Wed, 26 Nov 2014 06:48:15 GMT

Protected "4rug" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:48, 26 November 2014

OCA: New page: '''Unreleased structure''' The entry 4rug is ON HOLD Authors: Opatowsky, Y., Guez-Hadad, J. Description:

OCA — Wed, 26 Nov 2014 06:48:14 GMT

New page: '''Unreleased structure''' The entry 4rug is ON HOLD Authors: Opatowsky, Y., Guez-Hadad, J. Description:

New page

'''Unreleased structure'''

The entry 4rug is ON HOLD

Authors: Opatowsky, Y., Guez-Hadad, J.

Description: