4rv3 - Revision history

OCA at 08:29, 8 March 2023

OCA — Wed, 08 Mar 2023 08:29:19 GMT

←Older revision		Revision as of 08:29, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='4rv3' size='340' side='right'caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rv3' size='340' side='right'caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staae Staae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>, <scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [https://pdbe.org/4rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv3 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [~~http~~://pdbe.org/4rv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.	+	[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Phosphatidylinositol diacylglycerol-lyase]]~~	+	[[Category: Staphylococcus aureus subsp. aureus str. Newman]]
-	~~[[Category: Staae~~]]	+	[[Category: Eyles SJ]]
-	[[Category: Eyles~~, S J~~]]	+	[[Category: Gao J]]
-	[[Category: Gao, J]]	+	[[Category: Gershenson A]]
-	[[Category: Gershenson, A]]	+	[[Category: He T]]
-	[[Category: He, T]]	+	[[Category: Roberts MF]]
-	[[Category: Roberts~~, M F]]~~	+
-	~~[[Category: Cation-pi]]~~	+
-	~~[[Category: Encoded unnatural amino acid phospholipase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 07:02, 3 June 2020

OCA — Wed, 03 Jun 2020 07:02:56 GMT

←Older revision		Revision as of 07:02, 3 June 2020
Line 1:		Line 1:

	==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==		==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==
-	<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4rv3' size='340' side='right'caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://pdbe.org/4rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://pdbe.org/4rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
	[[Category: Staae]]		[[Category: Staae]]

OCA at 07:44, 29 August 2018

OCA — Wed, 29 Aug 2018 07:44:31 GMT

←Older revision		Revision as of 07:44, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
-	[[Category: ~~Staphylococcus aureus~~]]	+	[[Category: Staae]]
	[[Category: Eyles, S J]]		[[Category: Eyles, S J]]
	[[Category: Gao, J]]		[[Category: Gao, J]]

OCA at 14:12, 24 May 2017

OCA — Wed, 24 May 2017 14:12:44 GMT

←Older revision		Revision as of 14:12, 24 May 2017
Line 1:		Line 1:
		+
	==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==		==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==
	<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://pdbe.org/4rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rv3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase C\|Phospholipase C]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:36, 15 July 2015

OCA — Wed, 15 Jul 2015 07:36:00 GMT

←Older revision		Revision as of 07:36, 15 July 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.		[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cation-pi interactions, where protein aromatic residues supply pi systems while positive charged portion of phospholipid head groups are the cations, have been suggested as important binding modes for peripheral membrane proteins. However, aromatic amino acids can also insert into membranes and hydrophobically interact with lipid tails. Heretofore there has been no facile way to differentiate these two types of interactions. We show that specific incorporation of fluorinated amino acids into proteins can experimentally distinguish cation-pi interactions from membrane insertion of the aromatic side-chains. Fluorinated aromatic amino acids destabilize the cation-pi interactions by altering electrostatics of the aromatic ring while their increased hydrophobicity enhances membrane insertion. Incorporation of pentafluorophenylalanine or difluorotyrosine into a Staphylococcus aureus phosphatidylinositol-specific phospholipase C (PI-PLC) variant engineered to contain a specific PC-binding site demonstrates the effectiveness of this methodology. Applying this methodology to the plethora of tyrosine residues in Bacillus thuringiensis PI-PLC definitively identifies those involved in cation-pi interactions with PC. This powerful method can easily be used to determine the roles of aromatic residues in other peripheral membrane proteins and in integral membrane proteins.
		+
		+	Fluorinated aromatic amino acids distinguish cation-pi interactions from membrane insertion.,He T, Gershenson A, Eyles SJ, Lee YJ, Liu WR, Wang J, Gao J, Roberts MF J Biol Chem. 2015 Jun 19. pii: jbc.M115.668343. PMID:26092728<ref>PMID:26092728</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:19, 1 July 2015

OCA — Wed, 01 Jul 2015 12:19:47 GMT

←Older revision		Revision as of 12:19, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==
-		+	<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~The entry~~ 4rv3 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>
-	~~Authors~~: He, T., ~~Gershenson~~, A., ~~Eyles~~, S.J., ~~Gao, J~~., ~~Roberts, M~~.F.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>
-	~~Description~~: ~~Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C~~ (~~H258X~~)~~from~~ Staphylococcus aureus	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v16\|3v16]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphatidylinositol diacylglycerol-lyase]]
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Eyles, S J]]
		+	[[Category: Gao, J]]
	[[Category: Gershenson, A]]		[[Category: Gershenson, A]]
-	[[Category: Roberts, M.F]]
-	[[Category: Eyles, S.J]]
	[[Category: He, T]]		[[Category: He, T]]
-	[[Category: ~~Gao~~, J]]	+	[[Category: Roberts, M F]]
		+	[[Category: Cation-pi]]
		+	[[Category: Encoded unnatural amino acid phospholipase]]
		+	[[Category: Lyase]]
		+	[[Category: Tim barrel]]

OCA at 17:24, 24 December 2014

OCA — Wed, 24 Dec 2014 17:24:32 GMT

←Older revision		Revision as of 17:24, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus		Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus
		+	[[Category: Unreleased Structures]]
		+	[[Category: Gershenson, A]]
		+	[[Category: Roberts, M.F]]
		+	[[Category: Eyles, S.J]]
		+	[[Category: He, T]]
		+	[[Category: Gao, J]]

OCA at 13:32, 10 December 2014

OCA — Wed, 10 Dec 2014 13:32:17 GMT

←Older revision		Revision as of 13:32, 10 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4rv3 is ON HOLD	+	The entry 4rv3 is ON HOLD until Paper Publication

	Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F.		Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F.

	Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus		Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus

OCA: Protected "4rv3" [edit=sysop:move=sysop]

OCA — Wed, 03 Dec 2014 08:19:50 GMT

Protected "4rv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:19, 3 December 2014

OCA: New page: '''Unreleased structure''' The entry 4rv3 is ON HOLD Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F. Description: Crystal structure of a pentafluoro-Phe incorporat...

OCA — Wed, 03 Dec 2014 08:19:49 GMT

New page: '''Unreleased structure''' The entry 4rv3 is ON HOLD Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F. Description: Crystal structure of a pentafluoro-Phe incorporat...

New page

'''Unreleased structure'''

The entry 4rv3 is ON HOLD

Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F.

Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus