4rwa - Revision history

OCA at 17:57, 20 September 2023

OCA — Wed, 20 Sep 2023 17:57:35 GMT

←Older revision		Revision as of 17:57, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.28Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [https://pdbe.org/4rwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [https://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [https://pdbe.org/4rwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [https://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:31, 8 March 2023

OCA — Wed, 08 Mar 2023 08:31:16 GMT

←Older revision		Revision as of 08:31, 8 March 2023
Line 1:		Line 1:

	==Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)==		==Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)==
-	<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>	+	<StructureSection load='4rwa' size='340' side='right'caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [https://pdbe.org/4rwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [https://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4n6h\|4n6h]]~~, ~~[[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">OPRD, OPRD1, cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [~~http~~://pdbe.org/4rwa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.	+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/OPRD_HUMAN OPRD_HUMAN] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:22184124</ref> <ref>PMID:7808419</ref> <ref>PMID:8201839</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
-	[[Category: Ballet, S]]	+	[[Category: Homo sapiens]]
-	[[Category: Barty, A]]	+	[[Category: Large Structures]]
-	[[Category: Basu, S]]	+	[[Category: Synthetic construct]]
-	[[Category: Betti, C]]	+	[[Category: Ballet S]]
-	[[Category: Boutet, S]]	+	[[Category: Barty A]]
-	[[Category: Chapman~~, H N~~]]	+	[[Category: Basu S]]
-	[[Category: Cherezov, V]]	+	[[Category: Betti C]]
-	[[Category: Coe, J]]	+	[[Category: Boutet S]]
-	[[Category: Conrad~~, C E~~]]	+	[[Category: Chapman HN]]
-	[[Category: Fenalti, G]]	+	[[Category: Cherezov V]]
-	[[Category: Fromme, P]]	+	[[Category: Coe J]]
-	[[Category: Fromme, R]]	+	[[Category: Conrad CE]]
-	~~[[Category: GPCR, GPCR Network~~]]	+	[[Category: Fenalti G]]
-	[[Category: Gati, C]]	+	[[Category: Fromme P]]
-	[[Category: Giguere, P]]	+	[[Category: Fromme R]]
-	[[Category: Guillemyn, K]]	+	[[Category: Gati C]]
-	[[Category: Han~~, G W~~]]	+	[[Category: Giguere P]]
-	[[Category: Ishchenko, A]]	+	[[Category: Guillemyn K]]
-	[[Category: James, D]]	+	[[Category: Han GW]]
-	[[Category: Katritch, V]]	+	[[Category: Ishchenko A]]
-	[[Category: Liu, W]]	+	[[Category: James D]]
-	[[Category: Messerschmidt, M]]	+	[[Category: Katritch V]]
-	[[Category: Metz, M]]	+	[[Category: Liu W]]
-	[[Category: Oberthuer, D]]	+	[[Category: Messerschmidt M]]
-	[[Category: Roth~~, B L~~]]	+	[[Category: Metz M]]
-	[[Category: Schiller~~, P W~~]]	+	[[Category: Oberthuer D]]
-	[[Category: Spence~~, J C.H~~]]	+	[[Category: Roth BL]]
-	[[Category: Stevens~~, R C~~]]	+	[[Category: Schiller PW]]
-	[[Category: Tourwe, D]]	+	[[Category: Spence JCH]]
-	[[Category: Wang, D]]	+	[[Category: Stevens RC]]
-	[[Category: Weierstall, U]]	+	[[Category: Tourwe D]]
-	[[Category: White~~, T A~~]]	+	[[Category: Wang D]]
-	[[Category: Williams~~, G J~~]]	+	[[Category: Weierstall U]]
-	[[Category: Yefanov~~, O M~~]]	+	[[Category: White TA]]
-	[[Category: Yoon~~, C H~~]]	+	[[Category: Williams GJ]]
-	[[Category: Zatsepin~~, N A~~]]	+	[[Category: Yefanov OM]]
-	[[Category: Zhang, H]]	+	[[Category: Yoon CH]]
-	~~[[Category: Bifunctional peptide]]~~	+	[[Category: Zatsepin NA]]
-	~~[[Category: Bril]]~~	+	[[Category: Zhang H]]
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Gpcr network]]~~	+
-	~~[[Category: Gpcr signaling]]~~	+
-	~~[[Category: Human opioid receptor]]~~	+
-	~~[[Category: Lipidic cubic phase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 09:11, 22 November 2017

OCA — Wed, 22 Nov 2017 09:11:15 GMT

←Older revision		Revision as of 09:11, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>		<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n6h\|4n6h]], [[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n6h\|4n6h]], [[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OPRD, OPRD1, cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [http://pdbe.org/4rwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [http://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [http://pdbe.org/4rwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [http://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Ballet, S]]		[[Category: Ballet, S]]
	[[Category: Barty, A]]		[[Category: Barty, A]]

OCA at 01:22, 19 January 2017

OCA — Thu, 19 Jan 2017 01:22:54 GMT

←Older revision		Revision as of 01:22, 19 January 2017
Line 1:		Line 1:
		+
	==Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)==		==Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)==
	<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>		<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n6h\|4n6h]], [[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n6h\|4n6h]], [[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [http://www.ebi.ac.uk/pdbsum/4rwa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [http://pdbe.org/4rwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [http://www.ebi.ac.uk/pdbsum/4rwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rwa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:20, 1 April 2015

OCA — Wed, 01 Apr 2015 07:20:39 GMT

←Older revision		Revision as of 07:20, 1 April 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.		[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bifunctional mu- and delta-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human delta-OR bound to the bifunctional delta-OR antagonist and mu-OR agonist tetrapeptide H-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between H-Dmt and Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.
		+
		+	Structural basis for bifunctional peptide recognition at human delta-opioid receptor.,Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwe D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb , 16. PMID:25686086<ref>PMID:25686086</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:44, 14 January 2015

OCA — Wed, 14 Jan 2015 13:44:40 GMT

←Older revision		Revision as of 13:44, 14 January 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)==
-		+	<StructureSection load='4rwa' size='340' side='right' caption='[[4rwa]], [[Resolution\|resolution]] 3.28Å' scene=''>
-	~~The entry~~ 4rwa is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rwa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWA FirstGlance]. <br>
-	~~Authors~~: ~~Fenalti, G~~.~~, Zatsepin, N~~.A.~~, Betti, C~~.~~, Giguere, P~~.~~, Han, G~~.W.~~, Ishchenko, A~~.~~, Liu, W~~., ~~Guillemyn~~, K., ~~Zhang~~, H., ~~James~~, D., ~~Wang~~, D., ~~Weierstall, U~~.~~, Spence, J~~.C.~~H, Boutet, S~~., ~~Messerschmidt, M~~.~~, Williams, G~~.J., ~~Gati, C~~.~~, Yefanov, O~~.M., ~~White, T~~.A.~~, Oberthuer, D~~., Metz, M., Yoon, C.H., Barty, A., Chapman, H.N., Basu, S., Coe, J., Conrad, C.E., Fromme, R., Fromme, P., Tourwe, D., Schiller, P.W., Roth, B.L., Ballet, S., Katritch, V., Stevens, R.C., Cherezov, V., GPCR Network (GPCR)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n6h\|4n6h]], [[4ej4\|4ej4]], [[4rwd\|4rwd]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rwa RCSB], [http://www.ebi.ac.uk/pdbsum/4rwa PDBsum]</span></td></tr>
-	[[Category: ~~Zhang~~, H]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ballet, S]]
	[[Category: Barty, A]]		[[Category: Barty, A]]
-	[[Category: ~~Guillemyn~~, K]]	+	[[Category: Basu, S]]
-	[[Category: ~~Oberthuer~~, D]]	+	[[Category: Betti, C]]
-	[[Category: ~~Giguere~~, P]]	+	[[Category: Boutet, S]]
-	[[Category: ~~Yoon~~, C.H]]	+	[[Category: Chapman, H N]]
-	[[Category: ~~Tourwe~~, D]]	+	[[Category: Cherezov, V]]
		+	[[Category: Coe, J]]
		+	[[Category: Conrad, C E]]
		+	[[Category: Fenalti, G]]
	[[Category: Fromme, P]]		[[Category: Fromme, P]]
-	[[Category: Wang, D]]
-	[[Category: Weierstall, U]]
-	[[Category: Ishchenko, A]]
-	[[Category: Roth, B.L]]
-	[[Category: Stevens, R.C]]
-	[[Category: Conrad, C.E]]
-	[[Category: White, T.A]]
-	[[Category: Han, G.W]]
-	[[Category: Gati, C]]
-	[[Category: Williams, G.J]]
-	[[Category: Ballet, S]]
	[[Category: Fromme, R]]		[[Category: Fromme, R]]
-	[[Category: ~~Metz~~, M]]	+	[[Category: GPCR, GPCR Network]]
-	[[Category: ~~Zatsepin~~, N.A]]	+	[[Category: Gati, C]]
		+	[[Category: Giguere, P]]
		+	[[Category: Guillemyn, K]]
		+	[[Category: Han, G W]]
		+	[[Category: Ishchenko, A]]
		+	[[Category: James, D]]
	[[Category: Katritch, V]]		[[Category: Katritch, V]]
-	[[Category: Schiller, P.W]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
-	[[Category: Chapman, H.N]]
	[[Category: Messerschmidt, M]]		[[Category: Messerschmidt, M]]
-	[[Category: Spence, J.C.H, ~~Boutet~~, S]]	+	[[Category: Metz, M]]
-	[[Category: ~~Betti~~, C]]	+	[[Category: Oberthuer, D]]
-	[[Category: Yefanov, O.M]]	+	[[Category: Roth, B L]]
-	[[Category: ~~James~~, D]]	+	[[Category: Schiller, P W]]
-	[[Category: ~~Coe~~, J]]	+	[[Category: Spence, J C.H]]
-	[[Category: ~~Fenalti~~, G]]	+	[[Category: Stevens, R C]]
-	[[Category: ~~Basu, S~~]]	+	[[Category: Tourwe, D]]
-	[[Category: Gpcr ~~Network (~~Gpcr)]]	+	[[Category: Wang, D]]
-	[[Category: ~~Cherezov, V~~]]	+	[[Category: Weierstall, U]]
		+	[[Category: White, T A]]
		+	[[Category: Williams, G J]]
		+	[[Category: Yefanov, O M]]
		+	[[Category: Yoon, C H]]
		+	[[Category: Zatsepin, N A]]
		+	[[Category: Zhang, H]]
		+	[[Category: Bifunctional peptide]]
		+	[[Category: Bril]]
		+	[[Category: Gpcr]]
		+	[[Category: Gpcr network]]
		+	[[Category: Gpcr signaling]]
		+	[[Category: Human opioid receptor]]
		+	[[Category: Lipidic cubic phase]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structural genomic]]

OCA at 17:30, 24 December 2014

OCA — Wed, 24 Dec 2014 17:30:47 GMT

←Older revision		Revision as of 17:30, 24 December 2014
Line 6:		Line 6:

	Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)		Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)
		+	[[Category: Unreleased Structures]]
		+	[[Category: Zhang, H]]
		+	[[Category: Barty, A]]
		+	[[Category: Guillemyn, K]]
		+	[[Category: Oberthuer, D]]
		+	[[Category: Giguere, P]]
		+	[[Category: Yoon, C.H]]
		+	[[Category: Tourwe, D]]
		+	[[Category: Fromme, P]]
		+	[[Category: Wang, D]]
		+	[[Category: Weierstall, U]]
		+	[[Category: Ishchenko, A]]
		+	[[Category: Roth, B.L]]
		+	[[Category: Stevens, R.C]]
		+	[[Category: Conrad, C.E]]
		+	[[Category: White, T.A]]
		+	[[Category: Han, G.W]]
		+	[[Category: Gati, C]]
		+	[[Category: Williams, G.J]]
		+	[[Category: Ballet, S]]
		+	[[Category: Fromme, R]]
		+	[[Category: Metz, M]]
		+	[[Category: Zatsepin, N.A]]
		+	[[Category: Katritch, V]]
		+	[[Category: Schiller, P.W]]
		+	[[Category: Liu, W]]
		+	[[Category: Chapman, H.N]]
		+	[[Category: Messerschmidt, M]]
		+	[[Category: Spence, J.C.H, Boutet, S]]
		+	[[Category: Betti, C]]
		+	[[Category: Yefanov, O.M]]
		+	[[Category: James, D]]
		+	[[Category: Coe, J]]
		+	[[Category: Fenalti, G]]
		+	[[Category: Basu, S]]
		+	[[Category: Gpcr Network (Gpcr)]]
		+	[[Category: Cherezov, V]]

OCA at 11:07, 17 December 2014

OCA — Wed, 17 Dec 2014 11:07:24 GMT

←Older revision		Revision as of 11:07, 17 December 2014
Line 3:		Line 3:
	The entry 4rwa is ON HOLD		The entry 4rwa is ON HOLD

-	Authors: Fenalti, G., Zatsepin, N.A., Betti, C., Giguere, P., Han, G.W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J.C.H, Boutet, S., Messerschmidt, M., Williams, G.J., Gati, C., Yefanov, O.M., White, T.A., Oberthuer, D., Metz, M., Yoon, C.H., Barty, A., Chapman, H.N., Basu, S., Coe, J., Conrad, C.E., Fromme, R., Fromme, P., Tourwe, D., Schiller, P.W., Roth, B.L., Ballet, S., Katritch, V. , Stevens, R.C., Cherezov, V., GPCR Network (GPCR)	+	Authors: Fenalti, G., Zatsepin, N.A., Betti, C., Giguere, P., Han, G.W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J.C.H, Boutet, S., Messerschmidt, M., Williams, G.J., Gati, C., Yefanov, O.M., White, T.A., Oberthuer, D., Metz, M., Yoon, C.H., Barty, A., Chapman, H.N., Basu, S., Coe, J., Conrad, C.E., Fromme, R., Fromme, P., Tourwe, D., Schiller, P.W., Roth, B.L., Ballet, S., Katritch, V., Stevens, R.C., Cherezov, V., GPCR Network (GPCR)

	Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)		Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)

OCA: Protected "4rwa" [edit=sysop:move=sysop]

OCA — Wed, 10 Dec 2014 13:33:55 GMT

Protected "4rwa" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 10 December 2014

OCA: New page: '''Unreleased structure''' The entry 4rwa is ON HOLD Authors: Fenalti, G., Zatsepin, N.A., Betti, C., Giguere, P., Han, G.W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D....

OCA — Wed, 10 Dec 2014 13:33:54 GMT

New page: '''Unreleased structure''' The entry 4rwa is ON HOLD Authors: Fenalti, G., Zatsepin, N.A., Betti, C., Giguere, P., Han, G.W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D....

New page

'''Unreleased structure'''

The entry 4rwa is ON HOLD

Authors: Fenalti, G., Zatsepin, N.A., Betti, C., Giguere, P., Han, G.W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J.C.H, Boutet, S., Messerschmidt, M., Williams, G.J., Gati, C., Yefanov, O.M., White, T.A., Oberthuer, D., Metz, M., Yoon, C.H., Barty, A., Chapman, H.N., Basu, S., Coe, J., Conrad, C.E., Fromme, R., Fromme, P., Tourwe, D., Schiller, P.W., Roth, B.L., Ballet, S., Katritch, V. , Stevens, R.C., Cherezov, V., GPCR Network (GPCR)

Description: Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)