4s39 - Revision history

OCA at 18:02, 20 September 2023

OCA — Wed, 20 Sep 2023 18:02:41 GMT

←Older revision		Revision as of 18:02, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S39 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S39 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [https://pdbe.org/4s39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [https://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [https://pdbe.org/4s39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [https://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:42, 15 March 2023

OCA — Wed, 15 Mar 2023 10:42:23 GMT

←Older revision		Revision as of 10:42, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4s39' size='340' side='right'caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4s39' size='340' side='right'caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4S39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S39 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, ~~<scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [https://pdbe.org/4s39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [https://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]]~~, ~~[[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]<~~/~~b></td><td class="sblockDat">ispG, TTHA0305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [~~http~~://pdbe.org/4s39 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ISPG_THET8 ISPG_THET8]] Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.	+	[https://www.uniprot.org/uniprot/ISPG_THET8 ISPG_THET8] Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Abdel-Azeim, S]]	+	[[Category: Abdel-Azeim S]]
-	[[Category: Bacher, A]]	+	[[Category: Bacher A]]
-	~~[[Category: Dowd, B O~~]]	+	[[Category: Eppinger J]]
-	[[Category: Eppinger, J]]	+	[[Category: Frank A]]
-	[[Category: Frank, A]]	+	[[Category: Groll M]]
-	[[Category: Groll, M]]	+	[[Category: Guerra F]]
-	[[Category: Guerra, F]]	+	[[Category: Guodong R]]
-	[[Category: Guodong, R]]	+	[[Category: Li J]]
-	[[Category: Li, J]]	+	[[Category: O'Dowd B]]
-	[[Category: ~~Oldfield, E~~]]	+	[[Category: Oldfield E]]
-	[[Category: ~~Quitterer, F~~]]	+	[[Category: Quitterer F]]
-	[[Category: ~~Wang, K~~]]	+	[[Category: Wang K]]
-	[[Category: ~~Drug development]]~~	+
-	~~[[Category: Iron-sulfur enzyme]]~~	+
-	~~[[Category: Methylerythritol-phosphate pathway]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reaction mechanism]]~~	+
-	~~[[Category: Terpene biosynthesis~~]]	+

OCA at 10:04, 1 May 2019

OCA — Wed, 01 May 2019 10:04:31 GMT

←Older revision		Revision as of 10:04, 1 May 2019
Line 1:		Line 1:

	==IspG in complex with HMBPP==		==IspG in complex with HMBPP==
-	<StructureSection load='4s39' size='340' side='right' caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4s39' size='340' side='right'caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S39 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]], [[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]], [[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ispG, TTHA0305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [http://pdbe.org/4s39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [http://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [http://pdbe.org/4s39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [http://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4s39" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4s39" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[IspG\|IspG]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Thet8]]
	[[Category: Abdel-Azeim, S]]		[[Category: Abdel-Azeim, S]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]

OCA at 12:11, 12 April 2017

OCA — Wed, 12 Apr 2017 12:11:28 GMT

←Older revision		Revision as of 12:11, 12 April 2017
Line 1:		Line 1:
		+
	==IspG in complex with HMBPP==		==IspG in complex with HMBPP==
	<StructureSection load='4s39' size='340' side='right' caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4s39' size='340' side='right' caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]], [[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]], [[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [http://www.ebi.ac.uk/pdbsum/4s39 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [http://pdbe.org/4s39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [http://www.ebi.ac.uk/pdbsum/4s39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s39 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4s39" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:34, 30 April 2015

OCA — Thu, 30 Apr 2015 11:34:59 GMT

←Older revision		Revision as of 11:34, 30 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==IspG in complex with HMBPP==
		+	<StructureSection load='4s39' size='340' side='right' caption='[[4s39]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4s39]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S39 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g9p\|4g9p]], [[2y0f\|2y0f]], [[3noy\|3noy]], [[4s38\|4s38]], [[4s3a\|4s3a]], [[4s3b\|4s3b]], [[4s3c\|4s3c]], [[4s3d\|4s3d]], [[4s3e\|4s3e]], [[4s3f\|4s3f]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate_synthase (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.7.1 1.17.7.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s39 RCSB], [http://www.ebi.ac.uk/pdbsum/4s39 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISPG_THET8 ISPG_THET8]] Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IspG is the penultimate enzyme in non-mevalonate biosynthesis of the universal terpene building blocks isopentenyl diphosphate and dimethylallyl diphosphate. Its mechanism of action has been the subject of numerous studies but remained unresolved due to difficulties in identifying distinct reaction intermediates. Using a moderate reducing agent and an epoxide substrate analogue, we were now able to trap and crystallographically characterize various stages in the IspG-catalyzed conversion of 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate into (E)-1-hydroxy-2-methylbut-2-enyl-4-diphosphate. In addition, the enzyme's structure was determined in complex with several inhibitors. These results, combined with recent electron paramagnetic resonance data, allowed us to deduce a detailed and complete IspG catalytic mechanism, which describes all stages from initial ring opening to formation of (E)-1-hydroxy-2-methylbut-2-enyl-4-diphosphate via discrete radical and carbanion intermediates. The data presented in this article provide a guide for the design of selective drugs against many prokaryotic and eukaryotic pathogens to which the non-mevalonate pathway is essential for survival and virulence.

-	~~The entry 4s39 is ON HOLD until Paper Publication~~	+	Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [FeS] Enzyme IspG (GcpE).,Quitterer F, Frank A, Wang K, Rao G, O'Dowd B, Li J, Guerra F, Abdel-Azeim S, Bacher A, Eppinger J, Oldfield E, Groll M J Mol Biol. 2015 Apr 11. pii: S0022-2836(15)00225-9. doi:, 10.1016/j.jmb.2015.04.002. PMID:25868383<ref>PMID:25868383</ref>

-	~~Authors: Quitterer~~, F.~~, Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim,~~ S.~~, Bacher, A., Eppinger, J., Oldfield, E., Groll, M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: IspG in complex with HMBPP~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Abdel-Azeim, S]]		[[Category: Abdel-Azeim, S]]
-	[[Category: Li, J]]	+	[[Category: Bacher, A]]
		+	[[Category: Dowd, B O]]
	[[Category: Eppinger, J]]		[[Category: Eppinger, J]]
-	[[Category: ~~Quitterer~~, F]]	+	[[Category: Frank, A]]
		+	[[Category: Groll, M]]
	[[Category: Guerra, F]]		[[Category: Guerra, F]]
-	[[Category: Wang, K]]
-	[[Category: O'Dowd, B]]
-	[[Category: Frank, A]]
	[[Category: Guodong, R]]		[[Category: Guodong, R]]
		+	[[Category: Li, J]]
	[[Category: Oldfield, E]]		[[Category: Oldfield, E]]
-	[[Category: ~~Bacher~~, A]]	+	[[Category: Quitterer, F]]
-	[[Category: ~~Groll~~, M]]	+	[[Category: Wang, K]]
		+	[[Category: Drug development]]
		+	[[Category: Iron-sulfur enzyme]]
		+	[[Category: Methylerythritol-phosphate pathway]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reaction mechanism]]
		+	[[Category: Terpene biosynthesis]]

OCA at 09:52, 18 February 2015

OCA — Wed, 18 Feb 2015 09:52:34 GMT

←Older revision		Revision as of 09:52, 18 February 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4s39 is ON HOLD	+	The entry 4s39 is ON HOLD until Paper Publication

	Authors: Quitterer, F., Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E., Groll, M.		Authors: Quitterer, F., Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E., Groll, M.

OCA: Protected "4s39" [edit=sysop:move=sysop]

OCA — Sat, 07 Feb 2015 12:54:59 GMT

Protected "4s39" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:54, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 4s39 is ON HOLD Authors: Quitterer, F., Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J.,...

OCA — Sat, 07 Feb 2015 12:54:58 GMT

New page: '''Unreleased structure''' The entry 4s39 is ON HOLD Authors: Quitterer, F., Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J.,...

New page

'''Unreleased structure'''

The entry 4s39 is ON HOLD

Authors: Quitterer, F., Frank, A., Wang, K., Guodong, R., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E., Groll, M.

Description: IspG in complex with HMBPP
[[Category: Unreleased Structures]]
[[Category: Abdel-Azeim, S]]
[[Category: Li, J]]
[[Category: Eppinger, J]]
[[Category: Quitterer, F]]
[[Category: Guerra, F]]
[[Category: Wang, K]]
[[Category: O'Dowd, B]]
[[Category: Frank, A]]
[[Category: Guodong, R]]
[[Category: Oldfield, E]]
[[Category: Bacher, A]]
[[Category: Groll, M]]