4tku - Revision history

OCA at 00:46, 28 December 2023

OCA — Thu, 28 Dec 2023 00:46:25 GMT

←Older revision		Revision as of 00:46, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.43Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [https://pdbe.org/4tku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [https://www.ebi.ac.uk/pdbsum/4tku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [https://pdbe.org/4tku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [https://www.ebi.ac.uk/pdbsum/4tku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tku ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:44, 15 March 2023

OCA — Wed, 15 Mar 2023 10:44:27 GMT

←Older revision		Revision as of 10:44, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4tku' size='340' side='right'caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='4tku' size='340' side='right'caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [https://pdbe.org/4tku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [https://www.ebi.ac.uk/pdbsum/4tku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tku ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [~~http~~://pdbe.org/4tku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tku ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI~~]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]~~] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.	+	[https://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Nitrogenase\|Nitrogenase]]	+	*[[Nitrogenase 3D structures\|Nitrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 27:
	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Nitrogenase]]~~	+	[[Category: Einsle O]]
-	[[Category: Einsle, O]]	+	[[Category: Howard JB]]
-	[[Category: Howard~~, J B~~]]	+	[[Category: Perez K]]
-	[[Category: Perez, K]]	+	[[Category: Rees DC]]
-	[[Category: Rees~~, D C~~]]	+	[[Category: Spatzal T]]
-	[[Category: Spatzal, T]]	+
-	~~[[Category: Femo-cofactor]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:38, 1 May 2019

OCA — Wed, 01 May 2019 10:38:15 GMT

←Older revision		Revision as of 10:38, 1 May 2019
Line 1:		Line 1:

	==Reactivated Nitrogenase MoFe-protein from A. vinelandii==		==Reactivated Nitrogenase MoFe-protein from A. vinelandii==
-	<StructureSection load='4tku' size='340' side='right' caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>	+	<StructureSection load='4tku' size='340' side='right'caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKU FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
		+	[[Category: Large Structures]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]
	[[Category: Einsle, O]]		[[Category: Einsle, O]]

OCA at 09:09, 5 August 2016

OCA — Fri, 05 Aug 2016 09:09:23 GMT

←Older revision		Revision as of 09:09, 5 August 2016
Line 1:		Line 1:
		+
	==Reactivated Nitrogenase MoFe-protein from A. vinelandii==		==Reactivated Nitrogenase MoFe-protein from A. vinelandii==
	<StructureSection load='4tku' size='340' side='right' caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='4tku' size='340' side='right' caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://pdbe.org/4tku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tku ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4tku" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitrogenase\|Nitrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:03, 25 December 2014

OCA — Thu, 25 Dec 2014 01:03:17 GMT

←Older revision		Revision as of 01:03, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NIFD_AZOVI NIFD_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. [[http://www.uniprot.org/uniprot/NIFK_AZOVI NIFK_AZOVI]] This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	[[Category: Azotobacter vinelandii]]		[[Category: Azotobacter vinelandii]]
	[[Category: Nitrogenase]]		[[Category: Nitrogenase]]
-	[[Category: Einsle, O.]]	+	[[Category: Einsle, O]]
-	[[Category: Howard, J B.]]	+	[[Category: Howard, J B]]
-	[[Category: Perez, K.]]	+	[[Category: Perez, K]]
-	[[Category: Rees, D C.]]	+	[[Category: Rees, D C]]
-	[[Category: Spatzal, T.]]	+	[[Category: Spatzal, T]]
	[[Category: Femo-cofactor]]		[[Category: Femo-cofactor]]
	[[Category: Inhibition]]		[[Category: Inhibition]]
-	[[Category: Nitrogenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:52, 20 October 2014

OCA — Mon, 20 Oct 2014 08:52:07 GMT

←Older revision		Revision as of 08:52, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site. We report a crystal structure of carbon monoxide (CO)-inhibited nitrogenase molybdenum-iron (MoFe)-protein at 1.50 angstrom resolution, which reveals a CO molecule bridging Fe2 and Fe6 of the FeMo-cofactor. The mu2 binding geometry is achieved by replacing a belt-sulfur atom (S2B) and highlights the generation of a reactive iron species uncovered by the displacement of sulfur. The CO inhibition is fully reversible as established by regain of enzyme activity and reappearance of S2B in the 1.43 angstrom resolution structure of the reactivated enzyme. The substantial and reversible reorganization of the FeMo-cofactor accompanying CO binding was unanticipated and provides insights into a catalytically competent state of nitrogenase.
		+
		+	Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase.,Spatzal T, Perez KA, Einsle O, Howard JB, Rees DC Science. 2014 Sep 26;345(6204):1620-3. doi: 10.1126/science.1256679. PMID:25258081<ref>PMID:25258081</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 00:28, 2 October 2014

OCA — Thu, 02 Oct 2014 00:28:13 GMT

←Older revision		Revision as of 00:28, 2 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Reactivated Nitrogenase MoFe-protein from A. vinelandii==
-		+	<StructureSection load='4tku' size='340' side='right' caption='[[4tku]], [[Resolution\|resolution]] 1.43Å' scene=''>
-	~~The entry~~ 4tku is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4tku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TKU FirstGlance]. <br>
-	~~Authors~~: ~~Spatzal~~, T., ~~Perez~~, K., Einsle, O., Howard, J.B., Rees, D.C.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLF:FE(8)-S(7)+CLUSTER'>CLF</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=HCA:3-HYDROXY-3-CARBOXY-ADIPIC+ACID'>HCA</scene>, <scene name='pdbligand=ICS:IRON-SULFUR-MOLYBDENUM+CLUSTER+WITH+INTERSTITIAL+CARBON'>ICS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1n\|1m1n]], [[3u7q\|3u7q]], [[4tkv\|4tkv]]</td></tr>
-	~~Description~~:	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrogenase Nitrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.6.1 1.18.6.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tku RCSB], [http://www.ebi.ac.uk/pdbsum/4tku PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Azotobacter vinelandii]]
		+	[[Category: Nitrogenase]]
		+	[[Category: Einsle, O.]]
		+	[[Category: Howard, J B.]]
		+	[[Category: Perez, K.]]
		+	[[Category: Rees, D C.]]
		+	[[Category: Spatzal, T.]]
		+	[[Category: Femo-cofactor]]
		+	[[Category: Inhibition]]
		+	[[Category: Nitrogenase]]
		+	[[Category: Oxidoreductase]]

OCA at 07:07, 30 July 2014

OCA — Wed, 30 Jul 2014 07:07:42 GMT

←Older revision		Revision as of 07:07, 30 July 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4tku is ON HOLD	+	The entry 4tku is ON HOLD until Paper Publication

	Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.		Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.

	Description:		Description:

OCA: Protected "4tku" [edit=sysop:move=sysop]

OCA — Wed, 04 Jun 2014 04:59:50 GMT

Protected "4tku" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4tku is ON HOLD Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C. Description:

OCA — Wed, 04 Jun 2014 04:59:49 GMT

New page: '''Unreleased structure''' The entry 4tku is ON HOLD Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C. Description:

New page

'''Unreleased structure'''

The entry 4tku is ON HOLD

Authors: Spatzal, T., Perez, K., Einsle, O., Howard, J.B., Rees, D.C.

Description: