4trz - Revision history

OCA at 15:17, 8 November 2023

OCA — Wed, 08 Nov 2023 15:17:18 GMT

←Older revision		Revision as of 15:17, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [https://pdbe.org/4trz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [https://www.ebi.ac.uk/pdbsum/4trz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [https://pdbe.org/4trz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [https://www.ebi.ac.uk/pdbsum/4trz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:52, 15 March 2023

OCA — Wed, 15 Mar 2023 10:52:38 GMT

←Older revision		Revision as of 10:52, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4trz' size='340' side='right'caption='[[4trz]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4trz' size='340' side='right'caption='[[4trz]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trw\|4trw]], [[4try\|4try]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [https://pdbe.org/4trz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [https://www.ebi.ac.uk/pdbsum/4trz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trz ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [~~http~~://pdbe.org/4trz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4trz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4trz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Akaji, K]]	+	[[Category: Akaji K]]
-	[[Category: Akiyama, T]]	+	[[Category: Akiyama T]]
-	[[Category: Nakagawa, A]]	+	[[Category: Nakagawa A]]
-	[[Category: Sanjho, A]]	+	[[Category: Sanjho A]]
-	[[Category: Teruya, K]]	+	[[Category: Teruya K]]
-	[[Category: Yamashita, E]]	+	[[Category: Yamashita E]]
-	~~[[Category: Designed inhibitor]]~~	+
-	~~[[Category: Hydrase proteinase converting]]~~	+
-	~~[[Category: Hydrase-inhibitor complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 14:52, 10 May 2019

OCA — Fri, 10 May 2019 14:52:39 GMT

←Older revision		Revision as of 14:52, 10 May 2019
Line 1:		Line 1:
		+
	==Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor==		==Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor==
-	<StructureSection load='4trz' size='340' side='right' caption='[[4trz]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='4trz' size='340' side='right'caption='[[4trz]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trw\|4trw]], [[4try\|4try]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trw\|4trw]], [[4try\|4try]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [http://www.ebi.ac.uk/pdbsum/4trz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [http://pdbe.org/4trz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [http://www.ebi.ac.uk/pdbsum/4trz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4trz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4trz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Akaji, K]]		[[Category: Akaji, K]]

OCA at 06:41, 2 September 2015

OCA — Wed, 02 Sep 2015 06:41:00 GMT

←Older revision		Revision as of 06:41, 2 September 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>		[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A superior substrate sequence for BACE1 containing transition-state mimics at the scissile site was evaluated as a protease inhibitor. Hydroxymethylcarbonyl (HMC) and hydroxyethylamine (HEA) isosteres were selected as the transition state mimics, and incorporated into the scissile site of the superior sequence covering the P4 to P1' sites (Glu-Ile-Thi-Thi()Nva; ()denotes the cleavage site). Isosteres having different absolute configurations of the hydroxyl group were synthesized separately, and the effect of the configuration was evaluated. Configuration of the hydroxyl group of each isostere showed a marked effect on the inhibitory activity; anti-configuration to the scissile site substituent had potent inhibitory activity in an HMC-type inhibitor, whereas anti-configuration of HEA-type inhibitors showed no inhibitory activity. Structural evaluations based on X-ray crystallographic analyses of recombinant BACE1 in complex with each inhibitor provided insights into the protein-ligand interactions, especially at the prime sites.
		+
		+	Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors.,Hattori Y, Kobayashi K, Deguchi A, Nohara Y, Akiyama T, Teruya K, Sanjoh A, Nakagawa A, Yamashita E, Akaji K Bioorg Med Chem. 2015 Sep 1;23(17):5626-40. doi: 10.1016/j.bmc.2015.07.023. Epub , 2015 Jul 21. PMID:26264846<ref>PMID:26264846</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:20, 1 July 2015

OCA — Wed, 01 Jul 2015 12:20:45 GMT

←Older revision		Revision as of 12:20, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor==
-		+	<StructureSection load='4trz' size='340' side='right' caption='[[4trz]], [[Resolution\|resolution]] 3.25Å' scene=''>
-	~~The entry~~ 4trz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4trz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRZ FirstGlance]. <br>
-	~~Authors~~: ~~Akaji, K~~.~~, Teruya, K~~.~~, Akiyama, T~~.~~, Sanjho, A~~.~~, Yamashita, E~~.~~, Nakagawa, A~~.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene>, <scene name='pdbligand=TVA:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTYL]-L-NORVALINE'>TVA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trw\|4trw]], [[4try\|4try]]</td></tr>
-	~~Description~~: ~~Structure of BACE1 complex with~~ 2-~~thiophenyl HEA~~-~~type inhibitor~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4trz RCSB], [http://www.ebi.ac.uk/pdbsum/4trz PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Teruya~~, K]]	+	</table>
-	[[~~Category~~: ~~Nakagawa,~~ A]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Memapsin 2]]
	[[Category: Akaji, K]]		[[Category: Akaji, K]]
-	[[Category: Yamashita, E]]
-	[[Category: Sanjho, A]]
	[[Category: Akiyama, T]]		[[Category: Akiyama, T]]
		+	[[Category: Nakagawa, A]]
		+	[[Category: Sanjho, A]]
		+	[[Category: Teruya, K]]
		+	[[Category: Yamashita, E]]
		+	[[Category: Designed inhibitor]]
		+	[[Category: Hydrase proteinase converting]]
		+	[[Category: Hydrase-inhibitor complex]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 17:49, 24 December 2014

OCA — Wed, 24 Dec 2014 17:49:46 GMT

←Older revision		Revision as of 17:49, 24 December 2014
Line 6:		Line 6:

	Description: Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor		Description: Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor
		+	[[Category: Unreleased Structures]]
		+	[[Category: Teruya, K]]
		+	[[Category: Nakagawa, A]]
		+	[[Category: Akaji, K]]
		+	[[Category: Yamashita, E]]
		+	[[Category: Sanjho, A]]
		+	[[Category: Akiyama, T]]

OCA at 07:19, 23 July 2014

OCA — Wed, 23 Jul 2014 07:19:48 GMT

←Older revision		Revision as of 07:19, 23 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4trz is ON HOLD	+	The entry 4trz is ON HOLD until Paper Publication

	Authors: Akaji, K., Teruya, K., Akiyama, T., Sanjho, A., Yamashita, E., Nakagawa, A.		Authors: Akaji, K., Teruya, K., Akiyama, T., Sanjho, A., Yamashita, E., Nakagawa, A.

	Description: Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor		Description: Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor

OCA: Protected "4trz" [edit=sysop:move=sysop]

OCA — Wed, 25 Jun 2014 06:04:10 GMT

Protected "4trz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4trz is ON HOLD Authors: Akaji, K., Teruya, K., Akiyama, T., Sanjho, A., Yamashita, E., Nakagawa, A. Description: Structure of BACE1 complex with 2...

OCA — Wed, 25 Jun 2014 06:04:09 GMT

New page: '''Unreleased structure''' The entry 4trz is ON HOLD Authors: Akaji, K., Teruya, K., Akiyama, T., Sanjho, A., Yamashita, E., Nakagawa, A. Description: Structure of BACE1 complex with 2...

New page

'''Unreleased structure'''

The entry 4trz is ON HOLD

Authors: Akaji, K., Teruya, K., Akiyama, T., Sanjho, A., Yamashita, E., Nakagawa, A.

Description: Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor