4tt4 - Revision history

OCA at 07:22, 27 September 2023

OCA — Wed, 27 Sep 2023 07:22:58 GMT

←Older revision		Revision as of 07:22, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2~~, ~~L16, PRO2000 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenosinetriphosphatase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andersen, J]]	+	[[Category: Andersen J]]
-	[[Category: Bardenhagen, J]]	+	[[Category: Bardenhagen J]]
-	[[Category: Cardozo, M]]	+	[[Category: Cardozo M]]
-	[[Category: Do, M ~~Geck~~]]	+	[[Category: Geck Do M]]
-	[[Category: Jones, P]]	+	[[Category: Jones P]]
-	[[Category: Ladbury, J]]	+	[[Category: Ladbury J]]
-	[[Category: Lee, G]]	+	[[Category: Lee G]]
-	[[Category: Leo, E]]	+	[[Category: Leo E]]
-	[[Category: Leonard, P]]	+	[[Category: Leonard P]]
-	[[Category: Palmer, W]]	+	[[Category: Palmer W]]
-	[[Category: Petrocchi, A]]	+	[[Category: Petrocchi A]]
-	[[Category: Poncet-Montange, G]]	+	[[Category: Poncet-Montange G]]
-	[[Category: Shi, X]]	+	[[Category: Shi X]]
-	[[Category: Zhan, Y]]	+	[[Category: Zhan Y]]
-	~~[[Category: Bromodomain-acetylated histone complex]]~~	+
-	~~[[Category: Gene regulation~~]]	+

OCA at 10:06, 13 April 2022

OCA — Wed, 13 Apr 2022 10:06:04 GMT

←Older revision		Revision as of 10:06, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ALY~~:~~N(6)-ACETYLLYSINE~~'>~~ALY~~</scene>, <scene name='pdbligand=CL:~~CHLORIDE~~+ION'>CL</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [~~http~~://pdbe.org/4tt4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:42, 10 May 2019

OCA — Fri, 10 May 2019 14:42:10 GMT

←Older revision		Revision as of 14:42, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==		==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==
-	<StructureSection load='4tt4' size='340' side='right' caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://pdbe.org/4tt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://pdbe.org/4tt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4tt4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4tt4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Adenosinetriphosphatase]]		[[Category: Adenosinetriphosphatase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Andersen, J]]		[[Category: Andersen, J]]
	[[Category: Bardenhagen, J]]		[[Category: Bardenhagen, J]]

OCA at 01:09, 19 January 2017

OCA — Thu, 19 Jan 2017 01:09:46 GMT

←Older revision		Revision as of 01:09, 19 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==		==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==
	<StructureSection load='4tt4' size='340' side='right' caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4tt4' size='340' side='right' caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://pdbe.org/4tt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4tt4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 24 December 2014

OCA — Wed, 24 Dec 2014 10:50:53 GMT

←Older revision		Revision as of 10:50, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==
		+	<StructureSection load='4tt4' size='340' side='right' caption='[[4tt4]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tt2\|4tt2]], [[4tt6\|4tt6]], [[4tte\|4tte]], [[4tu4\|4tu4]], [[4tu6\|4tu6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Preventing histone recognition by bromodomains emerges as an attractive therapeutic approach in cancer. Overexpression of ATAD2A in cancer cells is associated with poor prognosis making the bromodomain of ATAD2A a promising epigenetic therapeutic target. In the development of an in vitro assay and identification of small molecule ligands, we conducted structure-guided studies which revealed a conformationally flexible ATAD2A bromodomain. Structural studies on apo-, peptide and small molecule-ATAD2A complexes (by co-crystalization) revealed the bromodomain adopts a "closed", histone-compatible conformation, and a more "open" ligand-compatible conformation of the binding-site respectively. An unexpected conformational change of the conserved asparagine residue plays an important role in driving the peptide-binding conformation remodelling. We also identified dimethylisoxazole-containing ligands as ATAD2A binders which aided in the validation of the in vitro screen and in the analysis of these conformational studies.

-	~~The entry 4tt4 is ON HOLD until Paper Publication~~	+	Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A.,Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee Iv GR, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE Biochem J. 2014 Dec 8. PMID:25486442<ref>PMID:25486442</ref>

-	~~Authors: Poncet-Montange~~, G.~~, Zhan, Y~~., Bardenhagen, J., ~~Petrocchi~~, A., ~~Leo, E., Shi, X.~~, Lee, G., Leonard, P~~., Geck Do, M., Cardozo, M.,~~ Palmer, W., ~~Andersen~~, J., ~~Jones, P.~~, ~~Ladbury, J.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenosinetriphosphatase]]
		+	[[Category: Andersen, J]]
		+	[[Category: Bardenhagen, J]]
		+	[[Category: Cardozo, M]]
		+	[[Category: Do, M Geck]]
		+	[[Category: Jones, P]]
		+	[[Category: Ladbury, J]]
		+	[[Category: Lee, G]]
		+	[[Category: Leo, E]]
		+	[[Category: Leonard, P]]
		+	[[Category: Palmer, W]]
		+	[[Category: Petrocchi, A]]
		+	[[Category: Poncet-Montange, G]]
		+	[[Category: Shi, X]]
		+	[[Category: Zhan, Y]]
		+	[[Category: Bromodomain-acetylated histone complex]]
		+	[[Category: Gene regulation]]

OCA at 09:55, 16 July 2014

OCA — Wed, 16 Jul 2014 09:55:25 GMT

←Older revision		Revision as of 09:55, 16 July 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4tt4 is ON HOLD	+	The entry 4tt4 is ON HOLD until Paper Publication

	Authors: Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.		Authors: Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.

-	Description: Crystal structure of ATAD2A bromodomain complexed with H3(1-21)~~K4Ac~~ peptide	+	Description: Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide

OCA: Protected "4tt4" [edit=sysop:move=sysop]

OCA — Wed, 25 Jun 2014 06:05:41 GMT

Protected "4tt4" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4tt4 is ON HOLD Authors: Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo...

OCA — Wed, 25 Jun 2014 06:05:39 GMT

New page: '''Unreleased structure''' The entry 4tt4 is ON HOLD Authors: Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo...

New page

'''Unreleased structure'''

The entry 4tt4 is ON HOLD

Authors: Poncet-Montange, G., Zhan, Y., Bardenhagen, J., Petrocchi, A., Leo, E., Shi, X., Lee, G., Leonard, P., Geck Do, M., Cardozo, M., Palmer, W., Andersen, J., Jones, P., Ladbury, J.

Description: Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K4Ac peptide