4tvk - Revision history

OCA at 12:25, 20 December 2023

OCA — Wed, 20 Dec 2023 12:25:03 GMT

←Older revision		Revision as of 12:25, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TVK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TVK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [https://pdbe.org/4tvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [https://www.ebi.ac.uk/pdbsum/4tvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [https://pdbe.org/4tvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [https://www.ebi.ac.uk/pdbsum/4tvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:57, 15 March 2023

OCA — Wed, 15 Mar 2023 10:57:36 GMT

←Older revision		Revision as of 10:57, 15 March 2023
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	==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR==		==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR==
-	<StructureSection load='4tvk' size='340' side='right' caption='[[4tvk]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4tvk' size='340' side='right'caption='[[4tvk]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tvk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Torpedo_californica Torpedo~~ californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TVK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TVK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [https://pdbe.org/4tvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [https://www.ebi.ac.uk/pdbsum/4tvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [~~http~~://pdbe.org/4tvk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tvk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~ACES_TORCA ACES_TORCA]~~] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.	+	[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase~~\|Acetylcholinesterase]]~~	+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures ~~of acetylcholinesterase~~\|3D structures ~~of acetylcholinesterase~~]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acetylcholinesterase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Torpedo~~ californica]]	+	[[Category: Tetronarce californica]]
-	[[Category: Lamba, D]]	+	[[Category: Lamba D]]
-	[[Category: Pesaresi, A]]	+	[[Category: Pesaresi A]]
-	[[Category: Samez, S]]	+	[[Category: Samez S]]
-	~~[[Category: Enzyme-inhibitor complex]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Multitarget drug]]~~	+
-	~~[[Category: Quinone]]~~	+
-	~~[[Category: Tacrine~~]]	+

OCA at 11:10, 5 August 2016

OCA — Fri, 05 Aug 2016 11:10:39 GMT

←Older revision		Revision as of 11:10, 5 August 2016
Line 1:		Line 1:
		+
	==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR==		==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR==
	<StructureSection load='4tvk' size='340' side='right' caption='[[4tvk]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4tvk' size='340' side='right' caption='[[4tvk]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [http://www.ebi.ac.uk/pdbsum/4tvk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [http://pdbe.org/4tvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [http://www.ebi.ac.uk/pdbsum/4tvk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4tvk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholinesterase\|Acetylcholinesterase]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:53, 25 December 2014

OCA — Thu, 25 Dec 2014 01:53:39 GMT

←Older revision		Revision as of 01:53, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [http://www.ebi.ac.uk/pdbsum/4tvk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [http://www.ebi.ac.uk/pdbsum/4tvk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
-	[[Category: Lamba, D.]]	+	[[Category: Lamba, D]]
-	[[Category: Pesaresi, A.]]	+	[[Category: Pesaresi, A]]
-	[[Category: Samez, S.]]	+	[[Category: Samez, S]]
	[[Category: Enzyme-inhibitor complex]]		[[Category: Enzyme-inhibitor complex]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:33, 8 October 2014

OCA — Wed, 08 Oct 2014 07:33:17 GMT

←Older revision		Revision as of 07:33, 8 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR==
		+	<StructureSection load='4tvk' size='340' side='right' caption='[[4tvk]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4tvk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TVK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TJH:2-({2-[(6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO]ETHYL}AMINO)-5-HYDROXYNAPHTHALENE-1,4-DIONE'>TJH</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tvk RCSB], [http://www.ebi.ac.uk/pdbsum/4tvk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 12-29 displayed excellent acetylcholinesterase (AChE) inhibitory potencies and interesting capabilities to block amyloid-beta (Abeta) aggregation. The X-ray analysis of AChE-20 complex allowed rationalizing the outstanding activity data (IC50 = 0.72 nM). Selected compounds 16 and 20 showed negligible toxicity in immortalized mouse cortical neurons Neuro2A and primary rat cerebellar granule neurons. However, only 16 was less hepatotoxic than tacrine in HepG2 cells. In T67 cells, 16 and 20 showed antioxidant activity, following NQO1 induction. Furthermore in Neuro2A, they were able to completely revert the decrease in viability induced by Abeta. Importantly, they crossed the blood-brain barrier, as demonstrated in ex vivo experiments with rats. When ex vivo results were combined with in vitro studies, 16 and 20 emerged to be promising multitarget lead candidates worthy of further pursuit.

-	~~The entry 4tvk is ON HOLD until Paper Publication~~	+	Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects.,Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML J Med Chem. 2014 Sep 26. PMID:25259726<ref>PMID:25259726</ref>

-	~~Authors: Pesaresi~~, A.~~, Samez,~~ S., Lamba, D.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH~~ A ~~CHLOROTACRINE~~-~~JUGLONE HYBRID INHIBITOR~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Torpedo californica]]
		+	[[Category: Lamba, D.]]
		+	[[Category: Pesaresi, A.]]
		+	[[Category: Samez, S.]]
		+	[[Category: Enzyme-inhibitor complex]]
		+	[[Category: Hydrolase]]
		+	[[Category: Multitarget drug]]
		+	[[Category: Quinone]]
		+	[[Category: Tacrine]]

OCA at 07:10, 30 July 2014

OCA — Wed, 30 Jul 2014 07:10:53 GMT

←Older revision		Revision as of 07:10, 30 July 2014
Line 5:		Line 5:
	Authors: Pesaresi, A., Samez, S., Lamba, D.		Authors: Pesaresi, A., Samez, S., Lamba, D.

-	Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A ~~CLOROTACRINE~~-JUGLONE HYBRID INHIBITOR	+	Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR

OCA at 06:58, 9 July 2014

OCA — Wed, 09 Jul 2014 06:58:50 GMT

←Older revision		Revision as of 06:58, 9 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4tvk is ON HOLD	+	The entry 4tvk is ON HOLD until Paper Publication

	Authors: Pesaresi, A., Samez, S., Lamba, D.		Authors: Pesaresi, A., Samez, S., Lamba, D.

	Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CLOROTACRINE-JUGLONE HYBRID INHIBITOR		Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CLOROTACRINE-JUGLONE HYBRID INHIBITOR

OCA: Protected "4tvk" [edit=sysop:move=sysop]

OCA — Wed, 02 Jul 2014 07:36:03 GMT

Protected "4tvk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:36, 2 July 2014

OCA: New page: '''Unreleased structure''' The entry 4tvk is ON HOLD Authors: Pesaresi, A., Samez, S., Lamba, D. Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CLOROTACRINE-JU...

OCA — Wed, 02 Jul 2014 07:36:02 GMT

New page: '''Unreleased structure''' The entry 4tvk is ON HOLD Authors: Pesaresi, A., Samez, S., Lamba, D. Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CLOROTACRINE-JU...

New page

'''Unreleased structure'''

The entry 4tvk is ON HOLD

Authors: Pesaresi, A., Samez, S., Lamba, D.

Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CLOROTACRINE-JUGLONE HYBRID INHIBITOR