4tyi - Revision history

OCA at 11:18, 9 May 2024

OCA — Thu, 09 May 2024 11:18:44 GMT

←Older revision		Revision as of 11:18, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [https://pdbe.org/4tyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [https://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [https://pdbe.org/4tyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [https://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:51, 22 March 2023

OCA — Wed, 22 Mar 2023 07:51:57 GMT

←Older revision		Revision as of 07:51, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4tyi' size='340' side='right'caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4tyi' size='340' side='right'caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [https://pdbe.org/4tyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [https://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGFR4, JTK2, TKF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [~~http~~://pdbe.org/4tyi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FGFR4_HUMAN FGFR4_HUMAN]] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.<ref>PMID:7680645</ref> <ref>PMID:7518429</ref> <ref>PMID:8663044</ref> <ref>PMID:11433297</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:17311277</ref> <ref>PMID:18480409</ref> <ref>PMID:18670643</ref> <ref>PMID:20683963</ref> <ref>PMID:20018895</ref> <ref>PMID:20798051</ref> <ref>PMID:21653700</ref> <ref>PMID:20876804</ref>	+	[https://www.uniprot.org/uniprot/FGFR4_HUMAN FGFR4_HUMAN] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.<ref>PMID:7680645</ref> <ref>PMID:7518429</ref> <ref>PMID:8663044</ref> <ref>PMID:11433297</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:17311277</ref> <ref>PMID:18480409</ref> <ref>PMID:18670643</ref> <ref>PMID:20683963</ref> <ref>PMID:20018895</ref> <ref>PMID:20798051</ref> <ref>PMID:21653700</ref> <ref>PMID:20876804</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor receptor\|Fibroblast growth factor receptor]]	+	*[[Fibroblast growth factor receptor 3D receptor\|Fibroblast growth factor receptor 3D receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Augustin M]]
-	[[Category: Augustin, M]]	+	[[Category: Huber R]]
-	[[Category: Huber, R]]	+	[[Category: Lammens A]]
-	[[Category: Lammens, A]]	+	[[Category: Lesca E]]
-	[[Category: Lesca, E]]	+
-	~~[[Category: Dovitinib]]~~	+
-	~~[[Category: Fibroblast growth factor receptor]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Ponatinb]]~~	+
-	~~[[Category: Proteros biostructures gmbh]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:50, 10 May 2019

OCA — Fri, 10 May 2019 14:50:51 GMT

←Older revision		Revision as of 14:50, 10 May 2019
Line 1:		Line 1:

	==Structural analysis of the human Fibroblast Growth Factor Receptor 4==		==Structural analysis of the human Fibroblast Growth Factor Receptor 4==
-	<StructureSection load='4tyi' size='340' side='right' caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='4tyi' size='340' side='right'caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGFR4, JTK2, TKF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://pdbe.org/4tyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://pdbe.org/4tyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Augustin, M]]		[[Category: Augustin, M]]

OCA at 22:07, 4 August 2016

OCA — Thu, 04 Aug 2016 22:07:02 GMT

←Older revision		Revision as of 22:07, 4 August 2016
Line 1:		Line 1:
		+
	==Structural analysis of the human Fibroblast Growth Factor Receptor 4==		==Structural analysis of the human Fibroblast Growth Factor Receptor 4==
	<StructureSection load='4tyi' size='340' side='right' caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4tyi' size='340' side='right' caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://pdbe.org/4tyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4tyi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fibroblast growth factor receptor\|Fibroblast growth factor receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:05, 24 December 2014

OCA — Wed, 24 Dec 2014 20:05:52 GMT

←Older revision		Revision as of 20:05, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGFR4_HUMAN FGFR4_HUMAN]] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.<ref>PMID:7680645</ref> <ref>PMID:7518429</ref> <ref>PMID:8663044</ref> <ref>PMID:11433297</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:17311277</ref> <ref>PMID:18480409</ref> <ref>PMID:18670643</ref> <ref>PMID:20683963</ref> <ref>PMID:20018895</ref> <ref>PMID:20798051</ref> <ref>PMID:21653700</ref> <ref>PMID:20876804</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:17, 10 December 2014

OCA — Wed, 10 Dec 2014 12:17:13 GMT

←Older revision		Revision as of 12:17, 10 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: Augustin, M.]]	+	[[Category: Augustin, M]]
-	[[Category: Huber, R.]]	+	[[Category: Huber, R]]
-	[[Category: Lammens, A.]]	+	[[Category: Lammens, A]]
-	[[Category: Lesca, E.]]	+	[[Category: Lesca, E]]
	[[Category: Dovitinib]]		[[Category: Dovitinib]]
	[[Category: Fibroblast growth factor receptor]]		[[Category: Fibroblast growth factor receptor]]

OCA at 10:23, 24 September 2014

OCA — Wed, 24 Sep 2014 10:23:58 GMT

←Older revision		Revision as of 10:23, 24 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structural analysis of the human Fibroblast Growth Factor Receptor 4==
		+	<StructureSection load='4tyi' size='340' side='right' caption='[[4tyi]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4tyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38O:4-AMINO-5-FLUORO-3-[5-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE'>38O</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tye\|4tye]], [[4tyg\|4tyg]], [[4tyj\|4tyj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyi RCSB], [http://www.ebi.ac.uk/pdbsum/4tyi PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The family of Fibroblast Growth Factor Receptors (FGFRs) plays an important and well characterized role in a variety of pathological disorders. FGFR4 is involved in myogenesis and muscle regeneration. Mutations affecting the kinase domain of FGFR4 may cause cancer e.g. breast cancer or rhabdomyosarcoma. Whereas FGFRs 1-3 have been structurally characterized, the structure of the FGFR4 kinase domain has not yet been reported. In this study we present four structures of the kinase domain of FGFR4, in its apo-form and in complex with different types of small-molecule inhibitors. The two apo-FGFR4 kinase domain structures show an activation segment similar in conformation to an autoinhibitory segment observed in the hepatocyte growth factor receptor kinase but different from the known structures of other FGFR kinases. The structures of FGFR4 in complex with the type I-inhibitor Dovitinib and the type II-inhibitor Ponatinib reveal the molecular interactions with different types of kinase inhibitors and may assist in the design and development of FGFR4-inhibitors.

-	~~The entry 4tyi is ON HOLD until Paper Publication~~	+	Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase.,Lesca E, Lammens A, Huber R, Augustin M J Mol Biol. 2014 Sep 11. pii: S0022-2836(14)00474-4. doi:, 10.1016/j.jmb.2014.09.004. PMID:25219510<ref>PMID:25219510</ref>

-	~~Authors: Lesca~~, E.~~, Lammens, A~~., Huber, R., ~~Augustin~~, M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structural analysis of the human~~ Fibroblast ~~Growth Factor Receptor 4~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Receptor protein-tyrosine kinase]]
		+	[[Category: Augustin, M.]]
		+	[[Category: Huber, R.]]
		+	[[Category: Lammens, A.]]
		+	[[Category: Lesca, E.]]
		+	[[Category: Dovitinib]]
		+	[[Category: Fibroblast growth factor receptor]]
		+	[[Category: Kinase]]
		+	[[Category: Ponatinb]]
		+	[[Category: Proteros biostructures gmbh]]
		+	[[Category: Transferase]]

OCA at 07:22, 23 July 2014

OCA — Wed, 23 Jul 2014 07:22:43 GMT

←Older revision		Revision as of 07:22, 23 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4tyi is ON HOLD	+	The entry 4tyi is ON HOLD until Paper Publication

	Authors: Lesca, E., Lammens, A., Huber, R., Augustin, M.		Authors: Lesca, E., Lammens, A., Huber, R., Augustin, M.

	Description: Structural analysis of the human Fibroblast Growth Factor Receptor 4		Description: Structural analysis of the human Fibroblast Growth Factor Receptor 4

OCA: Protected "4tyi" [edit=sysop:move=sysop]

OCA — Wed, 16 Jul 2014 09:57:20 GMT

Protected "4tyi" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4tyi is ON HOLD Authors: Lesca, E., Lammens, A., Huber, R., Augustin, M. Description: Structural analysis of the human Fibroblast Growth Factor Rec...

OCA — Wed, 16 Jul 2014 09:57:19 GMT

New page: '''Unreleased structure''' The entry 4tyi is ON HOLD Authors: Lesca, E., Lammens, A., Huber, R., Augustin, M. Description: Structural analysis of the human Fibroblast Growth Factor Rec...

New page

'''Unreleased structure'''

The entry 4tyi is ON HOLD

Authors: Lesca, E., Lammens, A., Huber, R., Augustin, M.

Description: Structural analysis of the human Fibroblast Growth Factor Receptor 4