4tyn - Revision history

OCA at 07:24, 27 September 2023

OCA — Wed, 27 Sep 2023 07:24:09 GMT

←Older revision		Revision as of 07:24, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='4tyn' size='340' side='right'caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='4tyn' size='340' side='right'caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.959Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MSS116, YDR194C, YD9346.05C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=559292 Baker~~'~~s yeast])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [https://pdbe.org/4tyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [https://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [https://pdbe.org/4tyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [https://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MS116_YEAST MS116_YEAST]] ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.<ref>PMID:2535893</ref> <ref>PMID:7567443</ref> <ref>PMID:12402239</ref> <ref>PMID:15618406</ref>	+	[https://www.uniprot.org/uniprot/MS116_YEAST MS116_YEAST] ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.<ref>PMID:2535893</ref> <ref>PMID:7567443</ref> <ref>PMID:12402239</ref> <ref>PMID:15618406</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~RNA helicase~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Lambowitz, A M~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Mallam, A L~~]]	+	[[Category: Lambowitz AM]]
-	[[Category: ~~Sidote, D J~~]]	+	[[Category: Mallam AL]]
-	[[Category: ~~Dead-box]]~~	+	[[Category: Sidote DJ]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Rna binding protein-dna complex]]~~	+
-	~~[[Category: Rna helicase~~]]	+

OCA at 10:51, 30 March 2022

OCA — Wed, 30 Mar 2022 10:51:47 GMT

←Older revision		Revision as of 10:51, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='4tyn' size='340' side='right'caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='4tyn' size='340' side='right'caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSS116, YDR194C, YD9346.05C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSS116, YDR194C, YD9346.05C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [~~http~~://pdbe.org/4tyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [https://pdbe.org/4tyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [https://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MS116_YEAST MS116_YEAST]] ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.<ref>PMID:2535893</ref> <ref>PMID:7567443</ref> <ref>PMID:12402239</ref> <ref>PMID:15618406</ref>	+	[[https://www.uniprot.org/uniprot/MS116_YEAST MS116_YEAST]] ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.<ref>PMID:2535893</ref> <ref>PMID:7567443</ref> <ref>PMID:12402239</ref> <ref>PMID:15618406</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Helicase\|Helicase]]	+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:28, 10 May 2019

OCA — Fri, 10 May 2019 14:28:46 GMT

←Older revision		Revision as of 14:28, 10 May 2019
Line 1:		Line 1:

	==DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF==		==DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF==
-	<StructureSection load='4tyn' size='340' side='right' caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>	+	<StructureSection load='4tyn' size='340' side='right'caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSS116, YDR194C, YD9346.05C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [http://pdbe.org/4tyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [http://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [http://pdbe.org/4tyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [http://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: RNA helicase]]		[[Category: RNA helicase]]
	[[Category: Lambowitz, A M]]		[[Category: Lambowitz, A M]]

OCA at 01:21, 19 January 2017

OCA — Thu, 19 Jan 2017 01:21:23 GMT

←Older revision		Revision as of 01:21, 19 January 2017
Line 1:		Line 1:
		+
	==DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF==		==DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF==
	<StructureSection load='4tyn' size='340' side='right' caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='4tyn' size='340' side='right' caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [http://www.ebi.ac.uk/pdbsum/4tyn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [http://pdbe.org/4tyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [http://www.ebi.ac.uk/pdbsum/4tyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4tyn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase\|Helicase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:43, 31 December 2014

OCA — Wed, 31 Dec 2014 14:43:52 GMT

←Older revision		Revision as of 14:43, 31 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF==
		+	<StructureSection load='4tyn' size='340' side='right' caption='[[4tyn]], [[Resolution\|resolution]] 2.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4tyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tyw\|4tyw]], [[4tyy\|4tyy]], [[4tz0\|4tz0]], [[4tz6\|4tz6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tyn RCSB], [http://www.ebi.ac.uk/pdbsum/4tyn PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MS116_YEAST MS116_YEAST]] ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Specifically involved in the ATP-dependent splicing of the bl1 intron of COB. Also required for efficient mitochondrial translation.<ref>PMID:2535893</ref> <ref>PMID:7567443</ref> <ref>PMID:12402239</ref> <ref>PMID:15618406</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How different helicase families with a conserved catalytic 'helicase core' evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. Here, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and mechanism. Our results define the molecular basis for the substrate specificity of a DEAD-box protein. Additionally, they show that Mss116 has ambiguous substrate-binding properties and interacts with all four NTPs and both RNA and DNA. The efficiency of unwinding correlates with the stability of the 'closed-state' helicase core, a complex with nucleotide and nucleic acid that forms as duplexes are unwound. Crystal structures reveal that core stability is modulated by family-specific interactions that favor certain substrates. This suggests how present-day helicases diversified from an ancestral core with broad specificity by retaining core closure as a common catalytic mechanism while optimizing substrate-binding interactions for different cellular functions.

-	~~The entry 4tyn is ON HOLD~~	+	Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase.,Mallam AL, Sidote DJ, Lambowitz AM Elife. 2014 Dec 12;3. doi: 10.7554/eLife.04630. PMID:25497230<ref>PMID:25497230</ref>

-	~~Authors: Mallam~~, A.L.~~, Sidote, D.J., Lambowitz, A.M~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Lambowitz, A.M]]	+	__TOC__
-	[[Category: Sidote, D.J]]	+	</StructureSection>
-	[[Category: ~~Mallam, A.L~~]]	+	[[Category: RNA helicase]]
		+	[[Category: Lambowitz, A M]]
		+	[[Category: Mallam, A L]]
		+	[[Category: Sidote, D J]]
		+	[[Category: Dead-box]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-dna complex]]
		+	[[Category: Rna binding protein-dna complex]]
		+	[[Category: Rna helicase]]

OCA at 17:59, 24 December 2014

OCA — Wed, 24 Dec 2014 17:59:26 GMT

←Older revision		Revision as of 17:59, 24 December 2014
Line 6:		Line 6:

	Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF		Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lambowitz, A.M]]
		+	[[Category: Sidote, D.J]]
		+	[[Category: Mallam, A.L]]

OCA: Protected "4tyn" [edit=sysop:move=sysop]

OCA — Wed, 16 Jul 2014 09:57:30 GMT

Protected "4tyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4tyn is ON HOLD Authors: Mallam, A.L., Sidote, D.J., Lambowitz, A.M. Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF

OCA — Wed, 16 Jul 2014 09:57:29 GMT

New page: '''Unreleased structure''' The entry 4tyn is ON HOLD Authors: Mallam, A.L., Sidote, D.J., Lambowitz, A.M. Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF

New page

'''Unreleased structure'''

The entry 4tyn is ON HOLD

Authors: Mallam, A.L., Sidote, D.J., Lambowitz, A.M.

Description: DEAD-box helicase Mss116 bound to ssDNA and ADP-BeF