4tz7 - Revision history

OCA at 00:48, 28 December 2023

OCA — Thu, 28 Dec 2023 00:48:52 GMT

←Older revision		Revision as of 00:48, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [https://pdbe.org/4tz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [https://www.ebi.ac.uk/pdbsum/4tz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tz7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.31Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [https://pdbe.org/4tz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [https://www.ebi.ac.uk/pdbsum/4tz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tz7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:52, 22 March 2023

OCA — Wed, 22 Mar 2023 07:52:52 GMT

←Older revision		Revision as of 07:52, 22 March 2023
Line 1:		Line 1:

	==Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish==		==Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish==
-	<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>	+	<StructureSection load='4tz7' size='340' side='right'caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pip5k1aa, pip5k1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [https://pdbe.org/4tz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [https://www.ebi.ac.uk/pdbsum/4tz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tz7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [~~http~~://pdbe.org/4tz7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4tz7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4tz7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q503I3_DANRE Q503I3_DANRE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
-	[[Category: Ha, Y]]	+	[[Category: Large Structures]]
-	[[Category: Hu, J]]	+	[[Category: Ha Y]]
-	[[Category: Li, L]]	+	[[Category: Hu J]]
-	[[Category: Qin, Y]]	+	[[Category: Li L]]
-	[[Category: Wang, J]]	+	[[Category: Qin Y]]
-	[[Category: Wu, D]]	+	[[Category: Wang J]]
-	~~[[Category: Kinase]]~~	+	[[Category: Wu D]]
-	~~[[Category: Transferase~~]]	+

OCA at 16:12, 16 November 2017

OCA — Thu, 16 Nov 2017 16:12:06 GMT

←Older revision		Revision as of 16:12, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish==		==Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish==
	<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>		<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [http://pdbe.org/4tz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz7 PDBsum]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pip5k1aa, pip5k1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [http://pdbe.org/4tz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tz7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Ha, Y]]		[[Category: Ha, Y]]
	[[Category: Hu, J]]		[[Category: Hu, J]]

OCA at 06:21, 30 September 2015

OCA — Wed, 30 Sep 2015 06:21:02 GMT

←Older revision		Revision as of 06:21, 30 September 2015
Line 1:		Line 1:
-	==Crystal ~~Structure~~ of a kinase==	+	==Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish==
	<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>		<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [http://pdbe.org/4tz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz7 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type I phosphatidylinositol phosphate kinase (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P) to generate PtdIns4,5P2, which plays important roles in a wide range of cellular functions including Wnt signalling. However, the lack of its structural information has hindered the understanding of its regulation. Here we report the crystal structure of the catalytic domain of zebrafish PIP5K1A at 3.3 A resolution. This molecule forms a side-to-side dimer. Mutagenesis study of PIP5K1A reveals two adjacent interfaces for the dimerization and interaction with the DIX domain of the Wnt signalling molecule dishevelled. Although these interfaces are located distally to the catalytic/substrate-binding site, binding to these interfaces either through dimerization or the interaction with DIX stimulates PIP5K1 catalytic activity. DIX binding additionally enhances PIP5K1 substrate binding. Thus, this study elucidates regulatory mechanisms for this lipid kinase and provides a paradigm for the understanding of PIP5K1 regulation by their interacting molecules.
		+
		+	Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled.,Hu J, Yuan Q, Kang X, Qin Y, Li L, Ha Y, Wu D Nat Commun. 2015 Sep 14;6:8205. doi: 10.1038/ncomms9205. PMID:26365782<ref>PMID:26365782</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4tz7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:29, 2 September 2015

OCA — Wed, 02 Sep 2015 12:29:15 GMT

←Older revision		Revision as of 12:29, 2 September 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of a kinase==
-		+	<StructureSection load='4tz7' size='340' side='right' caption='[[4tz7]], [[Resolution\|resolution]] 3.31Å' scene=''>
-	~~The entry~~ 4tz7 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4tz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZ7 FirstGlance]. <br>
-	~~Authors~~: ~~Hu, J~~.~~, Qin, Y~~.~~, Wang, J~~.~~, Li, L~~.~~, Wu, D~~.~~, Ha, Y~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz7 PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~: ~~Crystal Structure of a kinase~~	+	__TOC__
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</StructureSection>
	[[Category: Ha, Y]]		[[Category: Ha, Y]]
-	[[Category: Wang, J]]
-	[[Category: Qin, Y]]
	[[Category: Hu, J]]		[[Category: Hu, J]]
-	[[Category: Wu, D]]
	[[Category: Li, L]]		[[Category: Li, L]]
		+	[[Category: Qin, Y]]
		+	[[Category: Wang, J]]
		+	[[Category: Wu, D]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]

OCA at 18:00, 24 December 2014

OCA — Wed, 24 Dec 2014 18:00:12 GMT

←Older revision		Revision as of 18:00, 24 December 2014
Line 6:		Line 6:

	Description: Crystal Structure of a kinase		Description: Crystal Structure of a kinase
		+	[[Category: Unreleased Structures]]
		+	[[Category: Ha, Y]]
		+	[[Category: Wang, J]]
		+	[[Category: Qin, Y]]
		+	[[Category: Hu, J]]
		+	[[Category: Wu, D]]
		+	[[Category: Li, L]]

OCA at 07:47, 5 November 2014

OCA — Wed, 05 Nov 2014 07:47:12 GMT

←Older revision		Revision as of 07:47, 5 November 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4tz7 is ON HOLD	+	The entry 4tz7 is ON HOLD until Paper Publication

	Authors: Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y.		Authors: Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y.

	Description: Crystal Structure of a kinase		Description: Crystal Structure of a kinase

OCA: Protected "4tz7" [edit=sysop:move=sysop]

OCA — Wed, 16 Jul 2014 09:58:07 GMT

Protected "4tz7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:58, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4tz7 is ON HOLD Authors: Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y. Description: Crystal Structure of a kinase

OCA — Wed, 16 Jul 2014 09:58:06 GMT

New page: '''Unreleased structure''' The entry 4tz7 is ON HOLD Authors: Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y. Description: Crystal Structure of a kinase

New page

'''Unreleased structure'''

The entry 4tz7 is ON HOLD

Authors: Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y.

Description: Crystal Structure of a kinase