4u0n - Revision history

OCA at 15:18, 8 November 2023

OCA — Wed, 08 Nov 2023 15:18:51 GMT

←Older revision		Revision as of 15:18, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.102Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [https://pdbe.org/4u0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [https://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [https://pdbe.org/4u0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [https://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:55, 22 March 2023

OCA — Wed, 22 Mar 2023 07:55:12 GMT

←Older revision		Revision as of 07:55, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4u0n' size='340' side='right'caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4u0n' size='340' side='right'caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibch Vibch~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [https://pdbe.org/4u0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [https://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dncV, VC_0179 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [~~http~~://pdbe.org/4u0n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH]] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP.	+	[https://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Cyclic GMP-AMP synthase\|Cyclic GMP-AMP synthase]]	+	*[[Cyclic GMP-AMP synthase 3D synthase\|Cyclic GMP-AMP synthase 3D synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cyclic GMP-AMP synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vibch~~]]	+	[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
-	[[Category: Xiang, Y]]	+	[[Category: Xiang Y]]
-	[[Category: Zhu~~, D Y]]~~	+	[[Category: Zhu DY]]
-	~~[[Category: Mutation]]~~	+
-	~~[[Category: Regulation]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:46, 10 May 2019

OCA — Fri, 10 May 2019 14:46:34 GMT

←Older revision		Revision as of 14:46, 10 May 2019
Line 1:		Line 1:

	==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop==		==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop==
-	<StructureSection load='4u0n' size='340' side='right' caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4u0n' size='340' side='right'caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dncV, VC_0179 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://pdbe.org/4u0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://pdbe.org/4u0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>
Line 28:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Cyclic GMP-AMP synthase]]		[[Category: Cyclic GMP-AMP synthase]]
		+	[[Category: Large Structures]]
		+	[[Category: Vibch]]
	[[Category: Xiang, Y]]		[[Category: Xiang, Y]]
	[[Category: Zhu, D Y]]		[[Category: Zhu, D Y]]

OCA at 01:12, 19 January 2017

OCA — Thu, 19 Jan 2017 01:12:13 GMT

←Older revision		Revision as of 01:12, 19 January 2017
Line 1:		Line 1:
		+
	==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop==		==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop==
	<StructureSection load='4u0n' size='340' side='right' caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4u0n' size='340' side='right' caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://pdbe.org/4u0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u0n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclic GMP-AMP synthase\|Cyclic GMP-AMP synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:37, 25 December 2014

OCA — Thu, 25 Dec 2014 05:37:19 GMT

←Older revision		Revision as of 05:37, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DNCV_VIBCH DNCV_VIBCH]] Catalyzes the synthesis of cyclic AMP-GMP from ATP and GTP. Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, c-AMP-GMP is the dominant molecule produced by DncV in vivo. Is required for efficient V.cholerae intestinal colonization, and down-regulates the colonization-influencing process of chemotaxis. Is not active with dATP, TTP, UTP, and CTP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Cyclic GMP-AMP synthase]]		[[Category: Cyclic GMP-AMP synthase]]
-	[[Category: Xiang, Y.]]	+	[[Category: Xiang, Y]]
-	[[Category: Zhu, D Y.]]	+	[[Category: Zhu, D Y]]
	[[Category: Mutation]]		[[Category: Mutation]]
	[[Category: Regulation]]		[[Category: Regulation]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:38, 22 October 2014

OCA — Wed, 22 Oct 2014 08:38:26 GMT

←Older revision		Revision as of 08:38, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:39, 24 September 2014

OCA — Wed, 24 Sep 2014 06:39:07 GMT

←Older revision		Revision as of 06:39, 24 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop==
		+	<StructureSection load='4u0n' size='340' side='right' caption='[[4u0n]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TLL:N-[4-({[(6S)-2-AMINO-5-METHYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GAMMA-GLUTAMYL-L-GLUTAMIC+ACID'>TLL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u03\|4u03]], [[4u0l\|4u0l]], [[4u0m\|4u0m]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0n RCSB], [http://www.ebi.ac.uk/pdbsum/4u0n PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic dinucleotides are a newly expanded class of second messengers that contribute to the regulation of multiple different pathways in bacterial, eukaryotic, and archaeal cells. The recently identified Vibrio cholerae dinucleotide cyclase (DncV, the gene product of VC0179) can generate three different cyclic dinucleotides and preferentially synthesize a hybrid cyclic-GMP-AMP. Here, we report the crystal structural and functional studies of DncV. We unexpectedly observed a 5-methyltetrahydrofolate diglutamate (5MTHFGLU2) molecule bound in a surface pocket opposite the nucleotide substrate-binding groove of DncV. Subsequent mutagenesis and functional studies showed that the enzymatic activity of DncV is regulated by folate-like molecules, suggesting the existence of a signaling pathway that links folate-like metabolism cofactors to the regulation of cyclic dinucleotide second messenger synthesis. Sequence analysis showed that the residues involved in 5MTHFGLU2 binding are highly conserved in DncV orthologs, implying the presence of this regulation mechanism in a wide variety of bacteria.

-	~~The entry 4u0n is ON HOLD~~	+	Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates.,Zhu D, Wang L, Shang G, Liu X, Zhu J, Lu D, Wang L, Kan B, Zhang JR, Xiang Y Mol Cell. 2014 Sep 18;55(6):931-7. doi: 10.1016/j.molcel.2014.08.001. Epub 2014, Sep 4. PMID:25201413<ref>PMID:25201413</ref>

-	~~Authors~~: Xiang, Y., Zhu, D.Y.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of a GTP binding protein (deletion mutant)~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cyclic GMP-AMP synthase]]
		+	[[Category: Xiang, Y.]]
		+	[[Category: Zhu, D Y.]]
		+	[[Category: Mutation]]
		+	[[Category: Regulation]]
		+	[[Category: Transferase]]

OCA: Protected "4u0n" [edit=sysop:move=sysop]

OCA — Wed, 23 Jul 2014 07:24:18 GMT

Protected "4u0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:24, 23 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u0n is ON HOLD Authors: Xiang, Y., Zhu, D.Y. Description: Structure of a GTP binding protein (deletion mutant)

OCA — Wed, 23 Jul 2014 07:24:17 GMT

New page: '''Unreleased structure''' The entry 4u0n is ON HOLD Authors: Xiang, Y., Zhu, D.Y. Description: Structure of a GTP binding protein (deletion mutant)

New page

'''Unreleased structure'''

The entry 4u0n is ON HOLD

Authors: Xiang, Y., Zhu, D.Y.

Description: Structure of a GTP binding protein (deletion mutant)