4u2w - Revision history

OCA at 12:26, 20 December 2023

OCA — Wed, 20 Dec 2023 12:26:27 GMT

←Older revision		Revision as of 12:26, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Odorrana_versabilis Odorrana versabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U2W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Odorrana_versabilis Odorrana versabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U2W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [https://pdbe.org/4u2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [https://www.ebi.ac.uk/pdbsum/4u2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u2w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [https://pdbe.org/4u2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [https://www.ebi.ac.uk/pdbsum/4u2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u2w ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:58, 22 March 2023

OCA — Wed, 22 Mar 2023 07:58:50 GMT

←Older revision		Revision as of 07:58, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4u2w' size='340' side='right'caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='4u2w' size='340' side='right'caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U2W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Odorrana_versabilis Odorrana versabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U2W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [https://pdbe.org/4u2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [https://www.ebi.ac.uk/pdbsum/4u2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u2w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [~~http~~://pdbe.org/4u2w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u2w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u2w ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B1VC43_ODOVE B1VC43_ODOVE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Trypsin\|Trypsin]]	+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]	+	*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 28:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trypsin~~]]	+	[[Category: Odorrana versabilis]]
-	[[Category: Debowski, D]]	+	[[Category: Debowski D]]
-	[[Category: Dubin, G]]	+	[[Category: Dubin G]]
-	[[Category: Golik, P]]	+	[[Category: Golik P]]
-	[[Category: Grudnik, P]]	+	[[Category: Grudnik P]]
-	[[Category: Legowska, A]]	+	[[Category: Legowska A]]
-	[[Category: Malicki, S]]	+	[[Category: Malicki S]]
-	[[Category: Rolka, K]]	+	[[Category: Rolka K]]
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 10:53, 26 February 2020

OCA — Wed, 26 Feb 2020 10:53:43 GMT

←Older revision		Revision as of 10:53, 26 February 2020
Line 1:		Line 1:

	==Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin==		==Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin==
-	<StructureSection load='4u2w' size='340' side='right' caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>	+	<StructureSection load='4u2w' size='340' side='right'caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U2W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U2W FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Debowski, D]]		[[Category: Debowski, D]]

OCA at 01:18, 19 January 2017

OCA — Thu, 19 Jan 2017 01:18:13 GMT

←Older revision		Revision as of 01:18, 19 January 2017
Line 1:		Line 1:
		+
	==Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin==		==Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin==
	<StructureSection load='4u2w' size='340' side='right' caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='4u2w' size='340' side='right' caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [http://www.ebi.ac.uk/pdbsum/4u2w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [http://pdbe.org/4u2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [http://www.ebi.ac.uk/pdbsum/4u2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u2w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u2w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin\|Trypsin]]
		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:29, 14 January 2015

OCA — Wed, 14 Jan 2015 13:29:16 GMT

←Older revision		Revision as of 13:29, 14 January 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin==
		+	<StructureSection load='4u2w' size='340' side='right' caption='[[4u2w]], [[Resolution\|resolution]] 1.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U2W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u2w RCSB], [http://www.ebi.ac.uk/pdbsum/4u2w PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protease inhibitors of the Bowman-Birk (BBI) family are commonly found in plants and animals where they play a protective role against invading pathogens. Here we report an atomic resolution (1A) crystal structure of a peptide inhibitor isolated from a skin secretion of a Chinese bamboo odorous frog Huia versabilis (HV-BBI) in complex with trypsin. HV-BBI shares significant similarities in sequence with a previously described inhibitor from a diskless-fingered odorous frog Odorrana graham (ORB). However, the latter is characterized by more than a 16000 fold higher Ki against trypsin than HV-BBI. Comparative analysis of trypsin co-crystal structures of HV-BBI and ORB and additionally that of Sunflower Trypsin Inhibitor (SFTI-1) together with accessory information on the affinities of inhibitor variants allowed us to pinpoint the inhibitor moiety responsible for the observed large difference in activity and also to define the extent of modifications permissible within the common protease-binding loop scaffold of BBI inhibitors. We suggest that modifications outside of the inhibitory loop permit the evolution of specificity towards different enzymes characterized by trypsin-like specificity. This article is protected by copyright. All rights reserved.

-	~~The entry 4u2w is ON HOLD~~	+	Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.,Grudnik P, Debowski D, Legowska A, Malicki S, Golik P, Karna N, Rolka K, Dubin G Proteins. 2014 Dec 24. doi: 10.1002/prot.24750. PMID:25546528<ref>PMID:25546528</ref>

-	~~Authors: Grudnik~~, P.~~, Golik, P., Malicki,~~ S., Debowski, D~~., Legowska, A., Rolka, K.,~~ Dubin, G.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Trypsin]]
		+	[[Category: Debowski, D]]
		+	[[Category: Dubin, G]]
		+	[[Category: Golik, P]]
	[[Category: Grudnik, P]]		[[Category: Grudnik, P]]
		+	[[Category: Legowska, A]]
	[[Category: Malicki, S]]		[[Category: Malicki, S]]
-	[[Category: Debowski, D]]
-	[[Category: Dubin, G]]
	[[Category: Rolka, K]]		[[Category: Rolka, K]]
-	[[Category: ~~Legowska, A~~]]	+	[[Category: Hydrolase-inhibitor complex]]
-	[[Category: ~~Golik, P~~]]	+	[[Category: Inhibitor]]

OCA at 18:04, 24 December 2014

OCA — Wed, 24 Dec 2014 18:04:26 GMT

←Older revision		Revision as of 18:04, 24 December 2014
Line 5:		Line 5:
	Authors: Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G.		Authors: Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Grudnik, P]]
		+	[[Category: Malicki, S]]
		+	[[Category: Debowski, D]]
		+	[[Category: Dubin, G]]
		+	[[Category: Rolka, K]]
		+	[[Category: Legowska, A]]
		+	[[Category: Golik, P]]

OCA: Protected "4u2w" [edit=sysop:move=sysop]

OCA — Wed, 30 Jul 2014 07:15:15 GMT

Protected "4u2w" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 30 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u2w is ON HOLD Authors: Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G. Description:

OCA — Wed, 30 Jul 2014 07:15:14 GMT

New page: '''Unreleased structure''' The entry 4u2w is ON HOLD Authors: Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G. Description:

New page

'''Unreleased structure'''

The entry 4u2w is ON HOLD

Authors: Grudnik, P., Golik, P., Malicki, S., Debowski, D., Legowska, A., Rolka, K., Dubin, G.

Description: